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protein coding gene - gal102 (SPBPB2B2.11) - nucleotide-sugar 4,6-dehydratase

Gene summary

Standard name
gal102
Systematic ID
SPBPB2B2.11
Product
nucleotide-sugar 4,6-dehydratase
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
tgd1
UniProt ID
Q9HDU4
ORFeome ID
50/50C06
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 4483984..4487313 forward strand

Annotation

Disease association

MONDO:0014507 - Catel-Manzke syndrome

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GO biological process

GO:0009225 - nucleotide-sugar metabolic process

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GO cellular component

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0008460 - dTDP-glucose 4,6-dehydratase activity

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GO:0050377 - UDP-glucose 4,6-dehydratase activity

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Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000121 - abnormal sporulation

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Genotypes:

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0004806 - incomplete cell wall disassembly at cell fusion site

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Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

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Genotypes:

FYPO:0003731 - normal growth on galactose carbon source

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Genotypes:

FYPO:0010094 - normal growth on galactose/ethanol carbon source

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Genotypes:

FYPO:0001409 - normal growth on glycerol carbon source

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Genotypes:

FYPO:0003898 - normal growth on glycerol/ethanol carbon source

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Genotypes:

FYPO:0006014 - promiscuous mating

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0000084 - sensitive to 6-azauracil

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Genotypes:

FYPO:0001501 - sensitive to brefeldin A

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Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF16363GDP_Man_DehydNAD(P)-bd_domPfam
PS00061ADH_SHORTSc_DH/Rdtase_CSPROSITE patterns
G3DSA:3.40.50.720:FF:000304CATH-FunFam
G3DSA:3.40.50.720CATH-Gene3D
G3DSA:3.90.25.10CATH-Gene3D
SSF51735NAD(P)-bd_dom_sfSUPERFAMILY
PTHR43000PANTHER

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:42030144 - Gene loss, repression, amplification, and horizontal acquisition shape galactose/melibiose metabolism in fission yeast.
Du XM et al. Proc Natl Acad Sci U S A 2026 Apr 28;123(17):e2532532123
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:21075050 - New insights into galactose metabolism by Schizosaccharomyces pombe: isolation and characterization of a galactose-assimilating mutant.
Matsuzawa T et al. J Biosci Bioeng 2011 Feb;111(2):158-66
PMID:34460892 - Transcriptome sequencing and screening of genes related to glucose availability in Schizosaccharomyces pombe by RNA-seq analysis.
Tarhan Ç et al. Genet Mol Biol 2021;44(3):e20200245
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000003 - Gene Ontology annotation based on Enzyme Commission mapping
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:26173815 - Genome-wide screen of fission yeast mutants for sensitivity to 6-azauracil, an inhibitor of transcriptional elongation.
Zhou H et al. Yeast 2015 Oct;32(10):643-55