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protein coding gene - gal10 (SPBPB2B2.12c) - UDP-glucose 4-epimerase/aldose 1-epimerase Gal10

Gene summary

Standard name
gal10
Systematic ID
SPBPB2B2.12c
Product
UDP-glucose 4-epimerase/aldose 1-epimerase Gal10
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9HDU3
ORFeome ID
49/49D07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 4484023..4487535 reverse strand

Annotation

PBO:0004968 - 5.1.3.2

PBO:0004969 - 5.1.3.3

Disease association

MONDO:0009257 - galactose epimerase deficiency

References:

MONDO:0018116 - galactosemia

References:

MONDO:0019214 - inborn carbohydrate metabolic disorder

References:

MONDO:0005066 - metabolic disease

References:

MONDO:0958333 - thrombocytopenia 13, syndromic

References:

GO biological process

GO:0033499 - beta-D-galactose catabolic process via UDP-galactose, Leloir pathway

References:

GO:0052574 - UDP-galactose biosynthetic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO molecular function

GO:0004034 - aldose 1-epimerase activity

References:

GO:0030246 - carbohydrate binding

References:

GO:0003978 - UDP-glucose 4-epimerase activity

References:

Genome organisation

PBO:0091283 - divergently oriented to functionally related gene

Modification

MOD:00046 - O-phospho-L-serine

References:

Multi-locus phenotype

FYPO:0003730 - abolished cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0010092 - abolished cell population growth on galactose/ethanol carbon source

References:

Genotypes:

FYPO:0003728 - abolished protein galactosylation during vegetative growth

References:

Genotypes:

FYPO:0007296 - abolished UDP-galactose biosynthetic process

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0006807 - decreased galactose level in cell surface glycoprotein glycan

References:

Genotypes:

FYPO:0007290 - decreased UDP-glucose 4-epimerase activity

References:

Genotypes:

FYPO:0007292 - increased cytosolic UDP-galactose level

References:

Genotypes:

FYPO:0001409 - normal growth on glycerol carbon source

References:

Genotypes:

FYPO:0003898 - normal growth on glycerol/ethanol carbon source

References:

Genotypes:

FYPO:0001317 - normal RNA level during vegetative growth

References:

Genotypes:

FYPO:0000106 - sensitive to hygromycin B

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0007290 - decreased UDP-glucose 4-epimerase activity

References:

Genotypes:

FYPO:0004806 - incomplete cell wall disassembly at cell fusion site

References:

Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0003731 - normal growth on galactose carbon source

References:

Genotypes:

FYPO:0010094 - normal growth on galactose/ethanol carbon source

References:

Genotypes:

FYPO:0001409 - normal growth on glycerol carbon source

References:

Genotypes:

FYPO:0003898 - normal growth on glycerol/ethanol carbon source

References:

Genotypes:

FYPO:0007288 - normal protein galactosylation during vegetative growth

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01263Aldose_epimAldose_1/G6P_1-epimerasePfam
PF16363GDP_Man_DehydNAD(P)-bd_domPfam
cd05247UDP_G4E_1_SDR_eUDP_G4ECDD
cd09019galactose_mutarotase_likeGalactose_mutarotase-likeCDD
PS00545ALDOSE_1_EPIMERASEAld1_epimerase_CSPROSITE patterns
G3DSA:2.70.98.10:FF:000025CATH-FunFam
G3DSA:2.70.98.10GH-type_carb-bdCATH-Gene3D
G3DSA:3.40.50.720CATH-Gene3D
G3DSA:3.90.25.10CATH-Gene3D
SSF51735NAD(P)-bd_dom_sfSUPERFAMILY
SSF74650Gal_mutarotase_sf_domSUPERFAMILY
PTHR43725PANTHER
NF007956PRK10675.1NCBIFAM
TIGR01179galEUDP_G4ENCBIFAM

Orthologs

References / Literature

PMID:38899862 - Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast PHO regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1.
Schwer B et al. mBio 2024 Jun 20;:e0125224
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PB_REF:0000003 - Disease Association Curation
PMID:25117315 - A potential protective role for thiamine in glucose-driven oxidative stress.
Palabiyik B et al. Genet Mol Res 2014 Jul 25;13(3):5582-93
PMID:21075050 - New insights into galactose metabolism by Schizosaccharomyces pombe: isolation and characterization of a galactose-assimilating mutant.
Matsuzawa T et al. J Biosci Bioeng 2011 Feb;111(2):158-66
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:33245560 - Construction and characterization of a zinc-inducible gene expression vector in fission yeast.
Takahata S et al. Yeast 2021 Apr;38(4):251-261
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:22840777 - Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.
Kawashima SA et al. Chem Biol 2012 Jul 27;19(7):893-901
PMID:38133430 - Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP 6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast.
Bednor L et al. mBio 2023 Dec 22;:e0306223
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:42030144 - Gene loss, repression, amplification, and horizontal acquisition shape galactose/melibiose metabolism in fission yeast.
Du XM et al. Proc Natl Acad Sci U S A 2026 Apr 28;123(17):e2532532123
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
GO_REF:0000002 - Comments
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.
Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31
PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.
Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99
PMID:23254763 - Ght2⁺ is required for UDP-galactose synthesis from extracellular galactose by Schizosaccharomyces pombe.
Matsuzawa T et al. Appl Microbiol Biotechnol 2013 Jun;97(11):4957-64
PMID:34460892 - Transcriptome sequencing and screening of genes related to glucose availability in Schizosaccharomyces pombe by RNA-seq analysis.
Tarhan Ç et al. Genet Mol Biol 2021;44(3):e20200245
PMID:19942659 - Characterization of two different types of UDP-glucose/-galactose 4-epimerase involved in galactosylation in fission yeast.
Suzuki S et al. Microbiology (Reading) 2010 Mar;156(Pt 3):708-718