protein coding gene - fah1 (SPBPB8B6.03) - fatty acid amide hydrolase Fah1

Gene summary

Standard name: fah1
Systematic ID: SPBPB8B6.03
Product: fatty acid amide hydrolase Fah1
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: SPAP8B6.03
UniProt ID: Q8TFF9
ORFeome ID: 50/50H11
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 47428..49071 forward strand

Annotation

PBO:0003027 - 3.5.1.4

Disease association

MONDO:0011685 - polysubstance abuse, susceptibility to

References:

PB_REF:0000006

GO biological process

GO:0009062 - fatty acid catabolic process

References:

GO_REF:0000024

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO molecular function

GO:0017064 - fatty acid amide hydrolase activity

References:

GO_REF:0000024

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

PMID:29432178

Quantitative gene expression

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002060 - viable vegetative cell population

References:

PMID:20519959

Genotypes:

fah1delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

ID	Name	InterPro name	DB name
PF01425	Amidase	Amidase_dom	Pfam
PS00571	AMIDASES	Amidase_CS	PROSITE patterns
G3DSA:3.90.1300.10:FF:000003			CATH-FunFam
G3DSA:3.90.1300.10		AS_sf	CATH-Gene3D
SSF75304		AS_sf	SUPERFAMILY
PTHR46072			PANTHER
PIRSF001221	Amidase_fungi		PIRSF

Orthologs

FAAH (HGNC:3553) Homo sapiens
AMD2 (YDR242W) Saccharomyces cerevisiae

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.: Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20519959 - S. pombe genome deletion project: an update.: Spirek M et al. Cell Cycle 2010 Jun 15;9(12):2399-402