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protein coding gene - SPBPB8B6.05c - L-asparaginase

Gene summary

Systematic ID
SPBPB8B6.05c
Product
L-asparaginase
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAP8B6.05c
UniProt ID
Q8TFF8
ORFeome ID
51/51C09
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 54322..55567 reverse strand

Annotation

PBO:0000106 - 3.5.1.1

GO biological process

GO:0006530 - L-asparagine catabolic process

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GO cellular component

GO:0009986 - cell surface

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GO:0005737 - cytoplasm

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GO:0042597 - periplasmic space

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GO molecular function

GO:0004067 - asparaginase activity

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Modification

MOD:00006 - N-glycosylated residue

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MOD:01148 - ubiquitinylated lysine

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Protein sequence feature

SO:0000418 - signal_peptide

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SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000027 - ribosomal density decreased

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PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0009079 - resistance to calcofluor and sodium dodecyl sulfate

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0005193 - resistance to torin1

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00710AsparaginaseL-asparaginase_NPFAM
PF17763Asparaginase_CAsparaginase_CPFAM
cd08964L-asparaginase_IIAsnASE_IICDD
PS51732ASN_GLN_ASE_3Asparaginase/glutaminase-likePROSITE_PROFILES
SM00870Asparaginase_2Asparaginase/glutaminase-likeSMART
PR00139ASNGLNASEAsparaginase/glutaminase-likePRINTS
G3DSA:3.40.50.1170:FF:000001FUNFAM
SSF53774Glutaminase/AsparaginaseAsp/glu_Ase-like_sfSUPERFAMILY
G3DSA:3.40.50.1170L-asparaginase_N_sfGENE3D
G3DSA:3.40.50.40L-asparaginase_CGENE3D
PTHR11707L-ASPARAGINASEAsparaginase/glutaminase-likePANTHER
PIRSF001220L-ASNase_gatDAsparaginase/glutaminase-likePIRSF
PIRSF500176L_ASNasePIRSF
TIGR00520asnASE_IIAsnASE_IINCBIFAM

Orthologs

References / Literature

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:34389684 - Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1.
Schwer B et al. Proc Natl Acad Sci U S A 2021 Aug 17;118(33)
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000051 - S. pombe keyword mapping
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101