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protein coding gene - dps1 (SPBPJ4664.01) - decaprenyl diphosphate synthase subunit Dps1/Coq1

Gene summary

Standard name
dps1
Systematic ID
SPBPJ4664.01
Product
decaprenyl diphosphate synthase subunit Dps1/Coq1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
coq1, SPBPJ694.01, dps
UniProt ID
O43091
ORFeome ID
44/44A07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 684117..685682 forward strand

Annotation

PBO:0000788 - 2.5.1.-

Complementation

PBO:0036385 - functionally complemented by Bulleromyces albus DPS1

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PBO:0036335 - functionally complemented by human DLP1 AND DPS1

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PBO:0036383 - functionally complemented by human DPS1

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PBO:0036384 - functionally complemented by mouse SPS1

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PBO:0036387 - functionally complemented by Rhodotorula minuta DPS1

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PBO:0036386 - functionally complemented by Saitoella complicata DPS1

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Disease association

MONDO:0013837 - deafness-encephaloneuropathy-obesity-valvulopathy syndrome

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GO biological process

GO:0010142 - farnesyl diphosphate biosynthetic process, mevalonate pathway

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GO:0008299 - isoprenoid biosynthetic process

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GO:0006744 - ubiquinone biosynthetic process

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GO cellular component

GO:0032478 - heterotetrameric polyprenyl diphosphate synthase complex

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GO:0005739 - mitochondrion

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GO molecular function

GO:0097269 - all-trans-decaprenyl-diphosphate synthase activity

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Multi-locus phenotype

FYPO:0001712 - coenzyme Q10 absent from cell

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Genotypes:

FYPO:0000246 - growth auxotrophic for antioxidant

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0003374 - normal cellular coenzyme Q10 level

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Genotypes:

FYPO:0000103 - sensitive to copper

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Genotypes:

FYPO:0003559 - sensitive to doxorubicin

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000664 - abolished catalytic activity

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Genotypes:

FYPO:0001934 - abolished cell population growth on glycerol carbon source

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Genotypes:

FYPO:0003690 - abolished cell population growth on glycerol/ethanol carbon source

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Genotypes:

FYPO:0001712 - coenzyme Q10 absent from cell

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0002009 - decreased oxygen consumption during vegetative growth

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Genotypes:

FYPO:0001116 - decreased RNA level during cellular response to hydrogen peroxide

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0008128 - decreased vegetative cell population growth on low glucose

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Genotypes:

FYPO:0000246 - growth auxotrophic for antioxidant

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Genotypes:

FYPO:0003004 - increased cellular reactive oxygen species level during vegetative growth

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Genotypes:

FYPO:0001413 - increased cellular sulfide level

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Genotypes:

FYPO:0000343 - increased concentration of hydrogen sulfide in growth medium

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Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0007035 - normal growth on 5-fluorouracil

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Genotypes:

FYPO:0000093 - sensitive to arsenic

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Genotypes:

FYPO:0001701 - sensitive to bortezomib

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0003384 - sensitive to chromium

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Genotypes:

FYPO:0000102 - sensitive to cisplatin

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Genotypes:

FYPO:0001245 - sensitive to cobalt

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Genotypes:

FYPO:0000103 - sensitive to copper

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Genotypes:

FYPO:0003559 - sensitive to doxorubicin

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

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Genotypes:

FYPO:0004983 - sensitive to vorinostat

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Subunit composition

PBO:0015221 - heteromeric(2)

References:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00348polyprenyl_syntPolyprenyl_syntPFAM
cd00685Trans_IPPS_HTPolyprenyl_syntCDD
PS00444POLYPRENYL_SYNTHASE_2Polyprenyl_synt_CSPROSITE_PATTERNS
PS00723POLYPRENYL_SYNTHASE_1Polyprenyl_synt_CSPROSITE_PATTERNS
G3DSA:1.10.600.10:FF:000015FUNFAM
SSF48576Terpenoid synthasesIsoprenoid_synthase_dom_sfSUPERFAMILY
G3DSA:1.10.600.10Farnesyl Diphosphate SynthaseIsoprenoid_synthase_dom_sfGENE3D
PTHR12001GERANYLGERANYL PYROPHOSPHATE SYNTHASEPANTHER
SFLDS00005Isoprenoid_Synthase_Type_ISFLD

Orthologs

References / Literature

PMID:18665268 - Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.
Zuin A et al. PLoS One 2008 Jul 30;3(7):e2842
PMID:27053105 - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.
Burr R et al. J Biol Chem 2016 Jun 03;291(23):12171-83
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:26791325 - Predicting chemotherapeutic drug combinations through gene network profiling.
Nguyen TT et al. Sci Rep 2016 Jan 21;6:18658
PMID:27558664 - Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.
Guo L et al. G3 (Bethesda) 2016 Oct 13;6(10):3317-3333
PMID:9133618 - Analysis of the decaprenyl diphosphate synthase (dps) gene in fission yeast suggests a role of ubiquinone as an antioxidant.
Suzuki K et al. J Biochem 1997 Mar;121(3):496-505
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37859837 - In fission yeast, 65 non-essential mitochondrial proteins related to respiration and stress become essential in low-glucose conditions.
Mori A et al. R Soc Open Sci 2023 Oct;10(10):230404
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23365689 - Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeast.
Tay Z et al. PLoS One 2013;8(1):e55041
PMID:37445861 - Resistance to Chemotherapeutic 5-Fluorouracil Conferred by Modulation of Heterochromatic Integrity through Ino80 Function in Fission Yeast.
Lim KK et al. Int J Mol Sci 2023 Jun 26;24(13)
PMID:24911838 - Functional conservation of coenzyme Q biosynthetic genes among yeasts, plants, and humans.
Hayashi K et al. PLoS One 2014;9(6):e99038
PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.
Takeda K et al. PLoS One 2011;6(7):e22021
PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
Sun LL et al. PLoS Genet 2013;9(8):e1003715
PMID:25669599 - Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast.
Nguyen TT et al. Sci Rep 2015 Feb 11;5:8400
PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.
Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595
PMID:37156397 - Identification of novel coenzyme Q 10 biosynthetic proteins Coq11 and Coq12 in Schizosaccharomyces pombe.
Nishida I et al. J Biol Chem 2023 Jun;299(6):104797
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:14519123 - Fission yeast decaprenyl diphosphate synthase consists of Dps1 and the newly characterized Dlp1 protein in a novel heterotetrameric structure.
Saiki R et al. Eur J Biochem 2003 Oct;270(20):4113-21
PMID:18808426 - Comparison of a coq7 deletion mutant with other respiration-defective mutants in fission yeast.
Miki R et al. FEBS J 2008 Nov;275(21):5309-24
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:25647499 - Production of CoQ10 in fission yeast by expression of genes responsible for CoQ10 biosynthesis.
Moriyama D et al. Biosci Biotechnol Biochem 2015;79(6):1026-33
PMID:27837315 - Cloning and characterization of decaprenyl diphosphate synthase from three different fungi.
Moriyama D et al. Appl Microbiol Biotechnol 2017 Feb;101(4):1559-1571
PMID:14695938 - Pleiotropic phenotypes of fission yeast defective in ubiquinone-10 production. A study from the abc1Sp (coq8Sp) mutant.
Saiki R et al. Biofactors 2003;18(1-4):229-35
PMID:11092853 - Phenotypes of fission yeast defective in ubiquinone production due to disruption of the gene for p-hydroxybenzoate polyprenyl diphosphate transferase.
Uchida N et al. J Bacteriol 2000 Dec;182(24):6933-9
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:19120452 - Coq10, a mitochondrial coenzyme Q binding protein, is required for proper respiration in Schizosaccharomyces pombe.
Cui TZ et al. FEBS J 2009 Feb;276(3):748-59
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:16262699 - Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans.
Saiki R et al. FEBS J 2005 Nov;272(21):5606-22