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protein coding gene - mfm3 (SPBPJ4664.03) - M-factor precursor Mfm3

Gene summary

Standard name
mfm3
Systematic ID
SPBPJ4664.03
Product
M-factor precursor Mfm3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P40849
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 700364..700700 forward strand

Annotation

Comment

PBO:0012837 - mature peptide sequence is YTPKVPYM

GO biological process

GO:0007267 - cell-cell signaling

References:

GO:0062038 - positive regulation of pheromone response MAPK cascade

References:

GO cellular component

GO:0005576 - extracellular region

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GO molecular function

GO:0000772 - mating pheromone activity

References:

Modification

MOD:00114 - L-cysteine methyl ester

References:

MOD:00660 - methylated cysteine

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MOD:00111 - S-farnesyl-L-cysteine

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Multi-locus phenotype

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0003847 - h- specific sterility

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Genotypes:

FYPO:0000280 - sterile

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Genotypes:

Protein sequence feature

SO:0100011 - cleaved_peptide_region

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Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0009098 - increased cell population growth on mannitol carbon source

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Genotypes:

FYPO:0001147 - normal mating efficiency

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0016878 - Schizosaccharomyces pombe specific

Protein features

IDNameInterPro nameDB name
PF03855M-factorM-factorPFAM
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder

References / Literature

PMID:7900424 - Assessment of pheromone production and response in fission yeast by a halo test of induced sporulation.
Egel R et al. Yeast 1994 Oct;10(10):1347-54
PMID:9032282 - Genes encoding farnesyl cysteine carboxyl methyltransferase in Schizosaccharomyces pombe and Xenopus laevis.
Imai Y et al. Mol Cell Biol 1997 Mar;17(3):1543-51
PMID:9236781 - The Schizosaccharomyces pombe mam1 gene encodes an ABC transporter mediating secretion of M-factor.
Christensen PU et al. Mol Gen Genet 1997 Jun;255(2):226-36
PMID:9388671 - Proteases involved in the maturation of the M-factor mating pheromone in fission yeast.
Hughes M et al. Biochem Soc Trans 1997 Aug;25(3):447S
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:12501333 - Induction of sexual co-flocculation of heterothallic fission yeast (Schizosaccharomyces pombe) cells by mating pheromones.
Miyata M et al. J Gen Appl Microbiol 1997 Jun;43(3):169-174
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:25831518 - Molecular coevolution of a sex pheromone and its receptor triggers reproductive isolation in Schizosaccharomyces pombe.
Seike T et al. Proc Natl Acad Sci U S A 2015 Apr 07;112(14):4405-10
PMID:1547790 - Mating pheromones of the fission yeast Schizosaccharomyces pombe: purification and structural characterization of M-factor and isolation and analysis of two genes encoding the pheromone.
Davey J EMBO J 1992 Mar;11(3):951-60
PMID:8196631 - Analysis of the structural genes encoding M-factor in the fission yeast Schizosaccharomyces pombe: identification of a third gene, mfm3.
Kjaerulff S et al. Mol Cell Biol 1994 Jun;14(6):3895-905
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:9191271 - Isolation of yeast mutants hypersensitive to mating pheromones.
Davis K et al. Biochem Soc Trans 1997 May;25(2):227S
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:7651414 - Two-step activation of meiosis by the mat1 locus in Schizosaccharomyces pombe.
Willer M et al. Mol Cell Biol 1995 Sep;15(9):4964-70
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:8380233 - Schizosaccharomyces pombe map3+ encodes the putative M-factor receptor.
Tanaka K et al. Mol Cell Biol 1993 Jan;13(1):80-8