PomBase home

protein coding gene - pma2 (SPCC1020.01c) - plasma membrane P-type proton exporting ATPase, P3-type Pma2

Gene summary

Standard name
pma2
Systematic ID
SPCC1020.01c
Product
plasma membrane P-type proton exporting ATPase, P3-type Pma2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPCC1393.01
UniProt ID
P28876
ORFeome ID
29/29H03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 793179..796301 forward strand

Annotation

GO biological process

GO:0120029 - proton export across plasma membrane

References:

GO:0051453 - regulation of intracellular pH

References:

GO cellular component

GO:0032153 - cell division site

References:

GO:0051286 - cell tip

References:

GO:0005886 - plasma membrane

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0016887 - ATP hydrolysis activity

References:

GO:0008553 - P-type proton-exporting transporter activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00696 - phosphorylated residue

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0001176 - decreased cell population growth on sucrose carbon source

References:

Genotypes:

FYPO:0009077 - increased cell population growth on ethanol carbon source

References:

Genotypes:

FYPO:0001835 - normal growth on acidic medium

References:

Genotypes:

FYPO:0009079 - resistance to calcofluor and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

References:

Genotypes:

FYPO:0002693 - resistance to diamide

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009081 - resistance to potassium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0002767 - resistance to terbinafine

References:

Genotypes:

FYPO:0005193 - resistance to torin1

References:

Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0007928 - sensitive to ethylenediaminetetraacetic acid

References:

Genotypes:

FYPO:0000785 - sensitive to formamide

References:

Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

Protein features

IDNameInterPro nameDB name
PF00122E1-E2_ATPaseATPase_P-type_domAPfam
PF00690Cation_ATPase_NATPase_P-typ_cation-transptr_NPfam
PF00702HydrolasePfam
cd02076P-type_ATPase_HP-type_ATPase_IIIACDD
PS00154ATPASE_E1_E2ATPase_P-typ_P_sitePROSITE patterns
SM00831Cation_ATPase_NATPase_P-typ_cation-transptr_NSMART
PR00119CATATPASEPRINTS
PR00120HATPASEP_typ_ATPasePRINTS
G3DSA:2.70.150.10:FF:000011CATH-FunFam
G3DSA:3.40.1110.10:FF:000005CATH-FunFam
G3DSA:3.40.50.1000:FF:000008CATH-FunFam
G3DSA:1.20.1110.10CATH-Gene3D
G3DSA:2.70.150.10CATH-Gene3D
G3DSA:3.40.1110.10ATPase_P-typ_cyto_dom_NCATH-Gene3D
G3DSA:3.40.50.1000HAD_sfCATH-Gene3D
SSF56784HAD-like_sfSUPERFAMILY
SSF81653ATPase_P-typ_transduc_dom_A_sfSUPERFAMILY
SSF81665ATPase_P-typ_TM_dom_sfSUPERFAMILY
PTHR42861PANTHER
TIGR01494ATPase_P-typeP_typ_ATPaseNCBIFAM
TIGR01647ATPase-IIIA_HP-type_ATPase_IIIANCBIFAM
SFLDF00027p-type_atpaseP_typ_ATPase_HD_domSFLD
SFLDG00002C1.7:_P-type_atpase_likeSFLD
SFLDS00003Haloacid_DehalogenaseSFLD
Transmembrane alpha helixDeepTMHMM
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Negative-Polyelectrolytedisorder_predictionMobiDB-Negative-Polyelectrolyte
mobidb-lite-Polardisorder_predictionMobiDB-Polar
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte

Orthologs

References / Literature

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
PMID:1833395 - The pma1 and pma2 H(+)-ATPases from Schizosaccharomyces pombe are functionally interchangeable.
Ghislain M et al. J Biol Chem 1991 Sep 25;266(27):18276-9
PMID:34460892 - Transcriptome sequencing and screening of genes related to glucose availability in Schizosaccharomyces pombe by RNA-seq analysis.
Tarhan Ç et al. Genet Mol Biol 2021;44(3):e20200245
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.
Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28821619 - Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.
Burr R et al. J Biol Chem 2017 Sep 29;292(39):16333-16350
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000002 - Comments