protein coding gene - cwf23 (SPCC10H11.02) - DNAJ domain protein Cwf23

Gene summary

Standard name: cwf23
Systematic ID: SPCC10H11.02
Product: DNAJ domain protein Cwf23
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: SPCP31B10.01
UniProt ID: Q9P7C6
ORFeome ID: 11/11G04
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome III: 523948..525001 forward strand

Annotation

Complementation

PBO:0091916 - functionally complements S. cerevisiae CWC23

References:

PMID:30467716

GO biological process

GO:0000390 - spliceosomal complex disassembly

References:

PMID:30467716

GO cellular component

GO:0005730 - nucleolus

References:

PMID:16823372

GO:0005634 - nucleus

References:

PMID:16823372

GO:0005681 - spliceosomal complex

References:

PMID:11884590

GO:0005684 - U2-type spliceosomal complex

References:

GO_REF:0000024

GO molecular function

GO:0005515 - protein binding

References:

PMID:30467716

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

PMID:33313903

Quantitative gene expression

PBO:0006310 - protein level

References:

PMID:23101633

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

PMID:23697806

Genotypes:

cwf23delta

FYPO:0000314 - inviable after spore germination with elongated germ tube

References:

PMID:23697806

Genotypes:

cwf23delta

FYPO:0001042 - inviable after spore germination, single or double cell division

References:

PMID:23697806

Genotypes:

cwf23delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

cwf23delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF00226	DnaJ	DnaJ_domain	PFAM
cd06257	DnaJ	DnaJ_domain	CDD
PS00636	DNAJ_1	DnaJ_domain_CS	PROSITE_PATTERNS
PS50076	DNAJ_2	DnaJ_domain	PROSITE_PROFILES
SM00271	dnaj_3	DnaJ_domain	SMART
PR00625	JDOMAIN	DnaJ_domain	PRINTS
G3DSA:1.10.287.110:FF:000059			FUNFAM
SSF54928	RNA-binding domain, RBD	RBD_domain_sf	SUPERFAMILY
SSF46565	Chaperone J-domain	J_dom_sf	SUPERFAMILY
G3DSA:3.30.70.330		Nucleotide-bd_a/b_plait_sf	GENE3D
G3DSA:1.10.287.110	DnaJ domain	J_dom_sf	GENE3D
PTHR44313	DNAJ HOMOLOG SUBFAMILY C MEMBER 17	Pre-mRNA-splicing_ERAD	PANTHER
Coil	Coil		COILS
mobidb-lite-Disorder	disorder_prediction		MOBIDB-Disorder
mobidb-lite-Polyampholyte	disorder_prediction		MOBIDB-Polyampholyte

Orthologs

DNAJC17 (HGNC:25556) Homo sapiens
cwf23 (SJAG_02560) Schizosaccharomyces japonicus
CWC23 (YGL128C) Saccharomyces cerevisiae

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:30467716 - Co-evolution of spliceosomal disassembly interologs: crowning J-protein component with moonlighting RNA-binding activity.: Raut S et al. Curr Genet 2019 Apr;65(2):561-573
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.: Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:11884590 - Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.: Ohi MD et al. Mol Cell Biol 2002 Apr;22(7):2011-24
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.: Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28446597 - The histone variant H2A.Z promotes splicing of weak introns.: Nissen KE et al. Genes Dev 2017 Apr 01;31(7):688-701