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protein coding gene - cwf23 (SPCC10H11.02) - DNAJ domain protein Cwf23

Gene summary

Standard name
cwf23
Systematic ID
SPCC10H11.02
Product
DNAJ domain protein Cwf23
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPCP31B10.01
UniProt ID
Q9P7C6
ORFeome ID
11/11G04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 523948..525001 forward strand

Annotation

Complementation

PBO:0091916 - functionally complements S. cerevisiae CWC23

References:

GO biological process

GO:0000390 - spliceosomal complex disassembly

References:

GO cellular component

GO:0005730 - nucleolus

References:

GO:0005634 - nucleus

References:

GO:0005681 - spliceosomal complex

References:

GO:0005684 - U2-type spliceosomal complex

References:

GO molecular function

GO:0005515 - protein binding

References:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

References:

Genotypes:

FYPO:0001042 - inviable after spore germination, single or double cell division

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00226DnaJDnaJ_domainPfam
cd06257DnaJDnaJ_domainCDD
PS00636DNAJ_1DnaJ_domain_CSPROSITE patterns
PS50076DNAJ_2DnaJ_domainPROSITE profiles
SM00271DnaJDnaJ_domainSMART
PR00625JDOMAINDnaJ_domainPRINTS
G3DSA:1.10.287.110:FF:000059CATH-FunFam
G3DSA:1.10.287.110J_dom_sfCATH-Gene3D
G3DSA:3.30.70.330Nucleotide-bd_a/b_plait_sfCATH-Gene3D
SSF46565J_dom_sfSUPERFAMILY
SSF54928RBD_domain_sfSUPERFAMILY
PTHR44313Pre-mRNA-splicing_ERADPANTHER
CoilCOILS
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte

Orthologs

References / Literature

PMID:28446597 - The histone variant H2A.Z promotes splicing of weak introns.
Nissen KE et al. Genes Dev 2017 Apr 01;31(7):688-701
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:11884590 - Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.
Ohi MD et al. Mol Cell Biol 2002 Apr;22(7):2011-24
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:30467716 - Co-evolution of spliceosomal disassembly interologs: crowning J-protein component with moonlighting RNA-binding activity.
Raut S et al. Curr Genet 2019 Apr;65(2):561-573
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623