protein coding gene - sec15 (SPCC1183.01) - exocyst complex subunit Exo6

Gene summary

Standard name: sec15
Systematic ID: SPCC1183.01
Product: exocyst complex subunit Exo6
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: exo6, SPCC1672.13
UniProt ID: O75006
ORFeome ID: 38/38E05
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome III: 591772..595029 forward strand

Annotation

Disease association

MONDO:0019675 - spondyloepimetaphyseal dysplasia with joint laxity

References:

PB_REF:0000003

MONDO:0032724 - spondyloepimetaphyseal dysplasia with joint laxity, type 3

References:

PB_REF:0000006

GO biological process

GO:0006886 - intracellular protein transport

References:

GO_REF:0000051

GO:0090522 - vesicle tethering involved in exocytosis

References:

GO_REF:0000002

GO cellular component

GO:0000145 - exocyst

References:

GO_REF:0000024

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:30726745

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PMID:39367033

PomGeneEx:0000027 - ribosomal density decreased

References:

PMID:33313903

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

PMID:23697806

Genotypes:

sec15delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

sec15delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

PMID:21511999

Protein features

ID	Name	InterPro name	DB name
PF04091	Sec15_C	EXOC6/Sec15_C	PFAM
PF20651	EXOC6_Sec15_N	EXOC6_Sec15_N	PFAM
G3DSA:1.20.58.670:FF:000002			FUNFAM
G3DSA:1.10.357.30		EXOC6/Sec15_C_dom1	GENE3D
G3DSA:1.20.58.670	Dsl1p vesicle tethering complex, Tip20p subunit, domain D	EXOC6PINT-1/Sec15/Tip20_C_dom2	GENE3D
PTHR12702	SEC15	EXOC6/Sec15	PANTHER
PIRSF025007	Sec15	EXOC6/Sec15	PIRSF
Coil	Coil		COILS

Orthologs

EXOC6B (HGNC:17085) Homo sapiens
EXOC6 (HGNC:23196) Homo sapiens
sec15 (SJAG_03864) Schizosaccharomyces japonicus
SEC15 (YGL233W) Saccharomyces cerevisiae

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000002 - Comments
PB_REF:0000003 - Disease Association Curation
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:41171630 - Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis.: Singh D et al. Elife 2025 Oct 31;13
GO_REF:0000051 - S. pombe keyword mapping
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399