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protein coding gene - sec15 (SPCC1183.01) - exocyst complex subunit Exo6

Gene summary

Standard name
sec15
Systematic ID
SPCC1183.01
Product
exocyst complex subunit Exo6
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
exo6, SPCC1672.13
UniProt ID
O75006
ORFeome ID
38/38E05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 591772..595029 forward strand

Annotation

Disease association

MONDO:0019675 - spondyloepimetaphyseal dysplasia with joint laxity

References:

MONDO:0032724 - spondyloepimetaphyseal dysplasia with joint laxity, type 3

References:

GO biological process

GO:0006887 - exocytosis

References:

GO cellular component

GO:0000145 - exocyst

References:

GO molecular function

GO:7770062 - vesicle membrane tethering activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000027 - ribosomal density decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF04091Sec15_CEXOC6/Sec15_CPfam
PF20651EXOC6_Sec15_NEXOC6_Sec15_NPfam
G3DSA:1.20.58.670:FF:000002CATH-FunFam
G3DSA:1.10.357.30EXOC6/Sec15_C_dom1CATH-Gene3D
G3DSA:1.20.58.670EXOC6PINT-1/Sec15/Tip20_C_dom2CATH-Gene3D
PTHR12702EXOC6/Sec15PANTHER
PIRSF025007Sec15EXOC6/Sec15PIRSF
CoilCOILS

Orthologs

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PB_REF:0000003 - Disease Association Curation
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:41171630 - Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis.
Singh D et al. Elife 2025 Oct 31;13
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)