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protein coding gene - fxn1 (SPCC1183.03c) - mitochondrial [2Fe-2S] cluster assembly frataxin Fxn1

Gene summary

Standard name
fxn1
Systematic ID
SPCC1183.03c
Product
mitochondrial [2Fe-2S] cluster assembly frataxin Fxn1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
pfh1
UniProt ID
O74831
ORFeome ID
08/08D10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 595451..597258 reverse strand

Annotation

Disease association

MONDO:0100339 - Friedreich ataxia

References:

MONDO:0100340 - Friedreich ataxia 1

References:

MONDO:0005071 - nervous system disorder

References:

GO biological process

GO:0044571 - [2Fe-2S] cluster assembly

References:

GO:0006783 - heme biosynthetic process

References:

GO:0006879 - intracellular iron ion homeostasis

References:

GO cellular component

GO:0099128 - mitochondrial [2Fe-2S] assembly complex

References:

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0008047 - enzyme activator activity

References:

GO:0008199 - ferric iron binding

References:

GO:0004322 - ferroxidase activity

References:

GO:0034986 - iron chaperone activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Multi-locus phenotype

FYPO:0003238 - decreased anaerobic cell population growth

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

References:

Genotypes:

FYPO:0002014 - increased RNA level during cellular response to iron ion starvation

References:

Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002015 - sensitive to iron ion starvation

References:

Genotypes:

Protein sequence feature

SO:0100011 - cleaved_peptide_region

References:

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000014 - RNA present

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000359 - abnormal mitochondrial morphology

References:

Genotypes:

FYPO:0002008 - decreased aconitate hydratase activity

References:

Genotypes:

FYPO:0003238 - decreased anaerobic cell population growth

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0002012 - decreased level of iron ion starvation-repressed proteins

References:

Genotypes:

FYPO:0002009 - decreased oxygen consumption during vegetative growth

References:

Genotypes:

FYPO:0001422 - decreased protein processing during vegetative growth

References:

Genotypes:

FYPO:0000564 - decreased rate of cellular respiration

References:

Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

References:

Genotypes:

FYPO:0000921 - increased aconitate hydratase activity

References:

Genotypes:

FYPO:0005175 - increased catalase activity

References:

Genotypes:

FYPO:0002006 - increased cellular iron level

References:

Genotypes:

FYPO:0003004 - increased cellular reactive oxygen species level during vegetative growth

References:

Genotypes:

FYPO:0005176 - increased ferric-chelate reductase activity

References:

Genotypes:

FYPO:0002011 - increased level of hydrogen peroxide-induced proteins during vegetative growth

References:

Genotypes:

FYPO:0002010 - increased level of iron ion starvation-induced proteins

References:

Genotypes:

FYPO:0001255 - increased protein level during cellular response to oxygen

References:

Genotypes:

FYPO:0000219 - increased protein oxidation during vegetative growth

References:

Genotypes:

FYPO:0002014 - increased RNA level during cellular response to iron ion starvation

References:

Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

References:

Genotypes:

FYPO:0004131 - increased succinate dehydrogenase (ubiquinone) activity

References:

Genotypes:

FYPO:0003386 - increased superoxide dismutase activity

References:

Genotypes:

FYPO:0000313 - inviable after spore germination, without cell division, with abnormal germ tube morphology

References:

Genotypes:

FYPO:0001489 - inviable vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0002013 - normal protein oxidation during vegetative growth

References:

Genotypes:

FYPO:0001317 - normal RNA level during vegetative growth

References:

Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0002015 - sensitive to iron ion starvation

References:

Genotypes:

FYPO:0002016 - sensitive to oxygen

References:

Genotypes:

FYPO:0001119 - tapered vegetative cell

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01491Frataxin_CyayFrataxin/CyaYPfam
cd00503FrataxinCDD
PS01344FRATAXIN_1Frataxin_CSPROSITE patterns
PS50810FRATAXIN_2Frataxin/CyaYPROSITE profiles
SM01219Frataxin_CyayFrataxin/CyaYSMART
PR00904FRATAXINFrataxin/CyaYPRINTS
G3DSA:3.30.920.10Frataxin/CyaY_sfCATH-Gene3D
SSF55387Frataxin/CyaY_sfSUPERFAMILY
PTHR16821Frataxin/CyaYPANTHER
TIGR03421FeS_CyaYFrataxin/CyaYNCBIFAM
TIGR03422mito_frataxinFrataxinNCBIFAM

Orthologs

References / Literature

PMID:27026703 - The Structure of the Complex between Yeast Frataxin and Ferrochelatase: CHARACTERIZATION AND PRE-STEADY STATE REACTION OF FERROUS IRON DELIVERY AND HEME SYNTHESIS.
Söderberg C et al. J Biol Chem 2016 May 27;291(22):11887-98
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:34660592 - Biogenesis of Iron-Sulfur Clusters and Their Role in DNA Metabolism.
Shi R et al. Front Cell Dev Biol 2021;9:735678
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PB_REF:0000003 - Disease Association Curation
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:24997422 - The role of frataxin in fission yeast iron metabolism: implications for Friedreich's ataxia.
Wang Y et al. Biochim Biophys Acta 2014 Oct;1840(10):3022-33
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:23115244 - Cells lacking pfh1, a fission yeast homolog of mammalian frataxin protein, display constitutive activation of the iron starvation response.
Gabrielli N et al. J Biol Chem 2012 Dec 14;287(51):43042-51
GO_REF:0000002 - Comments
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000003 - Gene Ontology annotation based on Enzyme Commission mapping
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053