protein coding gene - lig4 (SPCC1183.05c) - DNA repair ligase Lig4

Gene summary

Standard name

lig4

Systematic ID

SPCC1183.05c

Product

DNA repair ligase Lig4

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O74833

ORFeome ID

30/30E05

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 599420..602916 reverse strand

Annotation

Protein features

Orthologs

• LIG4 (HGNC:6601) Homo sapiens
• lig4 (SJAG_02527) Schizosaccharomyces japonicus
• DNL4 (YOR005C) Saccharomyces cerevisiae

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:17038309 - Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos.

Hentges P et al. J Biol Chem 2006 Dec 08;281(49):37517-26

PMID:23188080 - The fission yeast MRN complex tethers dysfunctional telomeres for NHEJ repair.

Reis CC et al. EMBO J 2012 Dec 12;31(24):4576-86

PMID:23335786 - Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells.

Almeida H et al. Nucleic Acids Res 2013 Mar 01;41(5):3056-67

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:11029034 - Protection of telomeres by the Ku protein in fission yeast.

Baumann P et al. Mol Biol Cell 2000 Oct;11(10):3265-75

PMID:15226425 - Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.

Nakamura TM et al. Mol Cell Biol 2004 Jul;24(14):6215-30

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:21931565 - Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.

Langerak P et al. PLoS Genet 2011 Sep;7(9):e1002271

PMID:12861005 - Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres.

Tomita K et al. Mol Cell Biol 2003 Aug;23(15):5186-97

PMID:24847916 - Genome-wide screens for sensitivity to ionizing radiation identify the fission yeast nonhomologous end joining factor Xrc4.

Li J et al. G3 (Bethesda) 2014 May 21;4(7):1297-306

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:28334931 - Rgf1p (Rho1p GEF) is required for double-strand break repair in fission yeast.

Manjón E et al. Nucleic Acids Res 2017 May 19;45(9):5269-5284

PMID:17632059 - The telomere bouquet controls the meiotic spindle.

Tomita K et al. Cell 2007 Jul 13;130(1):113-26

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:25965521 - Ku stabilizes replication forks in the absence of Brc1.

Sánchez A et al. PLoS One 2015;10(5):e0126598

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:19798055 - Failed gene conversion leads to extensive end processing and chromosomal rearrangements in fission yeast.

Tinline-Purvis H et al. EMBO J 2009 Nov 04;28(21):3400-12

PMID:12628934 - Pathway utilization in response to a site-specific DNA double-strand break in fission yeast.

Prudden J et al. EMBO J 2003 Mar 17;22(6):1419-30

PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.

Chen JS et al. Yeast 2016 Sep;33(9):507-17

PMID:28292918 - Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe .

Li Y et al. Genetics 2017 May;206(1):481-496

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:18062930 - Functional characterisation of the Schizosaccharomyces pombe homologue of the leukaemia-associated translocation breakpoint binding protein translin and its binding partner, TRAX.

Jaendling A et al. Biochim Biophys Acta 2008 Feb;1783(2):203-13

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:16371652 - Production of reactive oxygen species in response to replication stress and inappropriate mitosis in fission yeast.

Marchetti MA et al. J Cell Sci 2006 Jan 01;119(Pt 1):124-31

PMID:11226171 - Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe.

Manolis KG et al. EMBO J 2001 Jan 15;20(1-2):210-21

PMID:18722173 - Chromosome fusions following telomere loss are mediated by single-strand annealing.

Wang X et al. Mol Cell 2008 Aug 22;31(4):463-473

PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.

Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:34499173 - Visual detection of binary, ternary and quaternary protein interactions in fission yeast using a Pil1 co-tethering assay.

Yu ZQ et al. J Cell Sci 2021 Oct 01;134(19)

PMID:25533340 - Cdk1 restrains NHEJ through phosphorylation of XRCC4-like factor Xlf1.

Hentges P et al. Cell Rep 2014 Dec 24;9(6):2011-7

PMID:17724078 - Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition.

Cullen JK et al. Mol Cell Biol 2007 Nov;27(21):7745-57

GO_REF:0000002 - Comments

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:18845326 - Omenn syndrome is associated with mutations in DNA ligase IV.

Grunebaum E et al. J Allergy Clin Immunol 2008 Dec;122(6):1219-20

PMID:11172711 - The fission yeast Taz1 protein protects chromosomes from Ku-dependent end-to-end fusions.

Ferreira MG et al. Mol Cell 2001 Jan;7(1):55-63

PMID:22093869 - Multiple end joining mechanisms repair a chromosomal DNA break in fission yeast.

Li P et al. DNA Repair (Amst) 2012 Feb 01;11(2):120-30