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protein coding gene - ung1 (SPCC1183.06) - uracil DNA N-glycosylase Ung1

Gene summary

Standard name
ung1
Systematic ID
SPCC1183.06
Product
uracil DNA N-glycosylase Ung1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74834
ORFeome ID
17/17B07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 602974..604420 forward strand

Annotation

PBO:0002003 - 3.2.2.-

Complementation

PBO:0091920 - functionally complemented by human nuclear UNG

References:

Disease association

MONDO:0011971 - hyper-IgM syndrome type 5

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GO biological process

GO:0006284 - base-excision repair

References:

GO:0097510 - base-excision repair, AP site formation via deaminated base removal

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GO:0043504 - mitochondrial DNA repair

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GO cellular component

GO:0005737 - cytoplasm

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GO:0005739 - mitochondrion

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GO:0005634 - nucleus

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GO molecular function

GO:0004844 - uracil DNA N-glycosylase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00696 - phosphorylated residue

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Multi-locus phenotype

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0000647 - vegetative cell lysis

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Genotypes:

Qualitative gene expression

PomGeneEx:0000026 - ribosomal density increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0007135 - increased level of AP sites in DNA

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0000256 - mutator

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Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF03167UDGUracil-DNA_glycosylase-likePfam
cd10027UDG-F1-likeUDG_fam1CDD
PS00130U_DNA_GLYCOSYLASEUra-DNA_Glyclase_ASPROSITE patterns
SM00986UDGUracil-DNA_glycosylase-likeSMART
SM00987UreE_CSMART
G3DSA:3.40.470.10:FF:000007CATH-FunFam
G3DSA:3.40.470.10Uracil-DNA_glycosylase-like_sfCATH-Gene3D
SSF52141Uracil-DNA_glycosylase-like_sfSUPERFAMILY
PTHR11264UDG_fam1PANTHER
NF003588PRK05254.1-1NCBIFAM
NF003589ungNCBIFAM
NF003592PRK05254.1-5NCBIFAM
TIGR00628ungUDG_fam1NCBIFAM
MF_00148UDGUDG_fam1HAMAP

Orthologs

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:22308326 - Tight coevolution of proliferating cell nuclear antigen (PCNA)-partner interaction networks in fungi leads to interspecies network incompatibility.
Zamir L et al. Proc Natl Acad Sci U S A 2012 Feb 14;109(7):E406-14
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.
Mak T et al. EMBO J 2021 Aug 16;40(16):e107911
PMID:12810074 - A fission yeast homologue of the human uracil-DNA-glycosylase and their roles in causing DNA damage after overexpression.
Elder RT et al. Biochem Biophys Res Commun 2003 Jul 04;306(3):693-700
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36