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protein coding gene - spo13 (SPCC1183.12) - sporulation specific RabGEF Spo13

Gene summary

Standard name
spo13
Systematic ID
SPCC1183.12
Product
sporulation specific RabGEF Spo13
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPNGAF60, SPNCRNA.546
UniProt ID
C6Y4C9
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 604366..604955 reverse strand

Annotation

GO biological process

GO:0030437 - ascospore formation

References:

GO:0032120 - ascospore-type prospore membrane formation

References:

GO:0031322 - ascospore-type prospore-specific spindle pole body remodeling

References:

GO cellular component

GO:0035974 - meiotic spindle pole body

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GO molecular function

GO:0005085 - guanyl-nucleotide exchange factor activity

References:

GO:0005515 - protein binding

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000015 - RNA absent

References:

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

References:

Genotypes:

FYPO:0000585 - abolished ascospore wall biogenesis

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Genotypes:

FYPO:0008290 - abolished guanyl-nucleotide exchange factor activity

References:

Genotypes:

FYPO:0001915 - abolished prospore membrane formation

References:

Genotypes:

FYPO:0003542 - abolished protein localization to meiotic spindle pole body

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Genotypes:

FYPO:0000583 - abolished sporulation

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Genotypes:

FYPO:0006051 - decreased lipid droplet localization to prospore membrane leading edge

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Genotypes:

FYPO:0000478 - normal meiosis

References:

Genotypes:

FYPO:0003541 - normal protein localization to meiotic spindle pole body

References:

Genotypes:

FYPO:0009068 - resistance to ciclopirox olamine

References:

Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0007808 - resistance to valproic acid

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0009082 - sensitive to potassium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

Taxonomic conservation

PBO:0000110 - orthologs cannot be distinguished

Warnings

PBO:0000406 - previously annotated as ncRNA

Protein features

IDNameInterPro nameDB name
PF06428Sec2pSec2_NPFAM
SSF144284Sec2 N-terminal regionSUPERFAMILY
G3DSA:6.10.140.910GENE3D
PTHR14430RABIN3-RELATEDRAB3IL/RAB3IP/Sec2PANTHER
CoilCoilCOILS
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMOBIDB-Low-complexity
mobidb-lite-Polardisorder_predictionMOBIDB-Polar

Orthologs

References / Literature

PMID:1417417 - Electron microscopic examination of sporulation-deficient mutants of the fission yeast Schizosaccharomyces pombe.
Hirata A et al. Arch Microbiol 1992;158(4):249-55
PMID:27630265 - The exocytic Rabs Ypt3 and Ypt2 regulate the early step of biogenesis of the spore plasma membrane in fission yeast.
Imada K et al. Mol Biol Cell 2016 Nov 01;27(21):3317-3328
PMID:20833892 - Schizosaccharomyces pombe calmodulin, Cam1, plays a crucial role in sporulation by recruiting and stabilizing the spindle pole body components responsible for assembly of the forespore membrane.
Itadani A et al. Eukaryot Cell 2010 Dec;9(12):1925-35
PMID:32761854 - Meiosis I Kinase Regulators: Conserved Orchestrators of Reductional Chromosome Segregation.
Galander S et al. Bioessays 2020 Oct;42(10):e2000018
PMID:20130084 - A guaninine nucleotide exchange factor is a component of the meiotic spindle pole body in Schizosaccharomyces pombe.
Yang HJ et al. Mol Biol Cell 2010 Apr 01;21(7):1272-81
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:3442824 - Genetic mapping of eleven spo genes essential for ascospore formation in the fission yeast Schizosaccharomyces pombe.
Kishida M et al. Curr Genet 1986;10(6):443-7
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:18367542 - Meiotic spindle pole bodies acquire the ability to assemble the spore plasma membrane by sequential recruitment of sporulation-specific components in fission yeast.
Nakase Y et al. Mol Biol Cell 2008 Jun;19(6):2476-87
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:21775631 - The fission yeast pleckstrin homology domain protein Spo7 is essential for initiation of forespore membrane assembly and spore morphogenesis.
Nakamura-Kubo M et al. Mol Biol Cell 2011 Sep;22(18):3442-55
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:28011631 - Lipid droplet dynamics during Schizosaccharomyces pombe sporulation and their role in spore survival.
Yang HJ et al. Biol Open 2017 Feb 15;6(2):217-222
PMID:34967420 - Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination.
Garg A et al. Nucleic Acids Res 2022 Jan 25;50(2):803-819
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12