protein coding gene - tea1 (SPCC1223.06) - cell end marker Tea1

Gene summary

Standard name

tea1

Systematic ID

SPCC1223.06

Product

cell end marker Tea1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

alp8

UniProt ID

P87061

ORFeome ID

48/48C11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 1848771..1852620 forward strand

Annotation

Protein features

Orthologs

• RABEPK (HGNC:16896) Homo sapiens
• tea1 (SJAG_01196) Schizosaccharomyces japonicus
• KEL2 (YGR238C) Saccharomyces cerevisiae
• KEL1 (YHR158C) Saccharomyces cerevisiae

References / Literature

PMID:12034771 - Roles of fission yeast tea1p in the localization of polarity factors and in organizing the microtubular cytoskeleton.

Behrens R et al. J Cell Biol 2002 May 27;157(5):783-93

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:16222337 - Multistep and multimode cortical anchoring of tea1p at cell tips in fission yeast.

Snaith HA et al. EMBO J 2005 Nov 02;24(21):3690-9

PMID:27852900 - Gradients of phosphatidylserine contribute to plasma membrane charge localization and cell polarity in fission yeast.

Haupt A et al. Mol Biol Cell 2017 Jan 01;28(1):210-220

PMID:29930085 - Local and global Cdc42 guanine nucleotide exchange factors for fission yeast cell polarity are coordinated by microtubules and the Tea1-Tea4-Pom1 axis.

Tay YD et al. J Cell Sci 2018 Jul 19;131(14)

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:18495844 - Interphase microtubule bundles use global cell shape to guide spindle alignment in fission yeast.

Daga RR et al. J Cell Sci 2008 Jun 15;121(Pt 12):1973-80

PMID:36202103 - Condensation of the fusion focus by the intrinsically disordered region of the formin Fus1 is essential for cell-cell fusion.

Billault-Chaumartin I et al. Curr Biol 2022 Nov 07;32(21):4752-4761.e10

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:22505610 - Cylindrical cellular geometry ensures fidelity of division site placement in fission yeast.

Mishra M et al. J Cell Sci 2012 Aug 15;125(Pt 16):3850-7

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:15837798 - Efficient formation of bipolar microtubule bundles requires microtubule-bound gamma-tubulin complexes.

Janson ME et al. J Cell Biol 2005 Apr 25;169(2):297-308

PMID:25210736 - Dynamics of cell shape inheritance in fission yeast.

Abenza JF et al. PLoS One 2014;9(9):e106959

PMID:26525038 - Casein kinase 1γ acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast.

Koyano T et al. Genes Cells 2015 Dec;20(12):1046-58

PMID:9372443 - Localisation of the Schizosaccharomyces pombe rho1p GTPase and its involvement in the organisation of the actin cytoskeleton.

Arellano M et al. J Cell Sci 1997 Oct;110 ( Pt 20):2547-55

PMID:12007420 - Tea3p is a cell end marker activating polarized growth in Schizosaccharomyces pombe.

Arellano M et al. Curr Biol 2002 Apr 30;12(9):751-6

PMID:23673619 - Spatial segregation of polarity factors into distinct cortical clusters is required for cell polarity control.

Dodgson J et al. Nat Commun 2013;4:1834

PMID:16988828 - Spatial regulation of cytokinesis by the Kin1 and Pom1 kinases in fission yeast.

La Carbona S et al. Curr Genet 2006 Dec;50(6):377-91

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:9405296 - Genes that cause aberrant cell morphology by overexpression in fission yeast: a role of a small GTP-binding protein Rho2 in cell morphogenesis.

Hirata D et al. J Cell Sci 1998 Jan;111 ( Pt 2):149-59

PMID:15936270 - Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe.

Tatebe H et al. Curr Biol 2005 Jun 07;15(11):1006-15

PMID:20850323 - A catalytic role for Mod5 in the formation of the Tea1 cell polarity landmark.

Bicho CC et al. Curr Biol 2010 Oct 12;20(19):1752-7

PMID:15827087 - End4/Sla2 is involved in establishment of a new growth zone in Schizosaccharomyces pombe.

Castagnetti S et al. J Cell Sci 2005 May 01;118(Pt 9):1843-50

PMID:30318352 - A Positive Feedback between Growth and Polarity Provides Directional Persistency and Flexibility to the Process of Tip Growth.

Haupt A et al. Curr Biol 2018 Oct 22;28(20):3342-3351.e3

PMID:9658169 - Identification of novel temperature-sensitive lethal alleles in essential beta-tubulin and nonessential alpha 2-tubulin genes as fission yeast polarity mutants.

Radcliffe P et al. Mol Biol Cell 1998 Jul;9(7):1757-71

PMID:31822915 - Mkt1 is required for RNAi-mediated silencing and establishment of heterochromatin in fission yeast.

Taglini F et al. Nucleic Acids Res 2020 Feb 20;48(3):1239-1253

PMID:12052869 - Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factors.

Papadaki P et al. Mol Cell Biol 2002 Jul;22(13):4598-606

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:26124291 - A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit.

Laporte D et al. J Cell Biol 2015 Jul 06;210(1):99-113

PMID:15809031 - Tea4p links microtubule plus ends with the formin for3p in the establishment of cell polarity.

Martin SG et al. Dev Cell 2005 Apr;8(4):479-91

PMID:15975911 - The novel fission yeast protein Pal1p interacts with Hip1-related Sla2p/End4p and is involved in cellular morphogenesis.

Ge W et al. Mol Biol Cell 2005 Sep;16(9):4124-38

PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.

Mak T et al. EMBO J 2021 Aug 16;40(16):e107911

PMID:39509469 - Rho1 and Rgf1 establish a new actin-dependent signal to determine growth poles in yeast independently of microtubules and the Tea1-Tea4 complex.

Garcia P et al. PLoS Biol 2024 Nov 07;22(11):e3002491

PMID:8187760 - Genetic analysis of cell morphogenesis in fission yeast--a role for casein kinase II in the establishment of polarized growth.

Snell V et al. EMBO J 1994 May 01;13(9):2066-74

PMID:9573052 - Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis.

Bähler J et al. Genes Dev 1998 May 01;12(9):1356-70

PMID:16611237 - Modulation of Alp4 function in Schizosaccharomyces pombe induces novel phenotypes that imply distinct functions for nuclear and cytoplasmic gamma-tubulin complexes.

Masuda H et al. Genes Cells 2006 Apr;11(4):319-36

PMID:17895368 - Schizosaccharomyces pombe protein phosphatase 1 in mitosis, endocytosis and a partnership with Wsh3/Tea4 to control polarised growth.

Alvarez-Tabarés I et al. J Cell Sci 2007 Oct 15;120(Pt 20):3589-601

PMID:19474789 - A spatial gradient coordinates cell size and mitotic entry in fission yeast.

Moseley JB et al. Nature 2009 Jun 11;459(7248):857-60

PMID:22891259 - Fission yeast Ags1 confers the essential septum strength needed for safe gradual cell abscission.

Cortés JC et al. J Cell Biol 2012 Aug 20;198(4):637-56

PMID:19474792 - Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle.

Martin SG et al. Nature 2009 Jun 11;459(7248):852-6

PMID:22137473 - Shaping fission yeast cells by rerouting actin-based transport on microtubules.

Lo Presti L et al. Curr Biol 2011 Dec 20;21(24):2064-9

PMID:19542312 - Functional genomics of adhesion, invasion, and mycelial formation in Schizosaccharomyces pombe.

Dodgson J et al. Eukaryot Cell 2009 Aug;8(8):1298-306

PMID:30973898 - Mal3 is a multi-copy suppressor of the sensitivity to microtubule-depolymerizing drugs and chromosome mis-segregation in a fission yeast pka1 mutant.

Tanabe T et al. PLoS One 2019;14(4):e0214803

PMID:27180904 - Sterol-Rich Membrane Domains Define Fission Yeast Cell Polarity.

Makushok T et al. Cell 2016 May 19;165(5):1182-1196

PMID:16951255 - S. pombe CLASP needs dynein, not EB1 or CLIP170, to induce microtubule instability and slows polymerization rates at cell tips in a dynein-dependent manner.

Grallert A et al. Genes Dev 2006 Sep 01;20(17):2421-36

PMID:22696680 - Fission yeast Alp14 is a dose-dependent plus end-tracking microtubule polymerase.

Al-Bassam J et al. Mol Biol Cell 2012 Aug;23(15):2878-90

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:12764130 - The kelch repeat protein, Tea1, is a potential substrate target of the p21-activated kinase, Shk1, in the fission yeast, Schizosaccharomyces pombe.

Kim H et al. J Biol Chem 2003 Aug 08;278(32):30074-82

PMID:14506270 - The novel Rho GTPase-activating protein family protein, Rga8, provides a potential link between Cdc42/p21-activated kinase and Rho signaling pathways in the fission yeast, Schizosaccharomyces pombe.

Yang P et al. J Biol Chem 2003 Dec 05;278(49):48821-30

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:20624911 - Asp1, a conserved 1/3 inositol polyphosphate kinase, regulates the dimorphic switch in Schizosaccharomyces pombe.

Pöhlmann J et al. Mol Cell Biol 2010 Sep;30(18):4535-47

PMID:12894167 - Targeted movement of cell end factors in fission yeast.

Browning H et al. Nat Cell Biol 2003 Sep;5(9):812-8

PMID:14663827 - Role of Tea1p, Tea3p and Pom1p in the determination of cell ends in Schizosaccharomyces pombe.

Niccoli T et al. Yeast 2003 Dec;20(16):1349-58

PMID:11007487 - CLIP170-like tip1p spatially organizes microtubular dynamics in fission yeast.

Brunner D et al. Cell 2000 Sep 01;102(5):695-704

PMID:15184402 - Regulation of a formin complex by the microtubule plus end protein tea1p.

Feierbach B et al. J Cell Biol 2004 Jun 07;165(5):697-707

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:39156640 - Fission yeast Bgs1 glucan synthase participates in the control of growth polarity and membrane traffic.

Ramos M et al. iScience 2024 Aug 16;27(8):110477

PMID:11018050 - Tea2p is a kinesin-like protein required to generate polarized growth in fission yeast.

Browning H et al. J Cell Biol 2000 Oct 02;151(1):15-28

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:20870879 - Reorganization of the growth pattern of Schizosaccharomyces pombe in invasive filament formation.

Dodgson J et al. Eukaryot Cell 2010 Nov;9(11):1788-97

PMID:23093943 - Cytokinesis-based constraints on polarized cell growth in fission yeast.

Bohnert KA et al. PLoS Genet 2012;8(10):e1003004

PMID:19646873 - The conserved NDR kinase Orb6 controls polarized cell growth by spatial regulation of the small GTPase Cdc42.

Das M et al. Curr Biol 2009 Aug 11;19(15):1314-9

PMID:21703453 - A phosphorylation cycle shapes gradients of the DYRK family kinase Pom1 at the plasma membrane.

Hachet O et al. Cell 2011 Jun 24;145(7):1116-28

PMID:23447405 - Quantitative analysis of human ras localization and function in the fission yeast Schizosaccharomyces pombe.

Bond M et al. Yeast 2013 Apr;30(4):145-56

PMID:23615447 - Compartmentalized nodes control mitotic entry signaling in fission yeast.

Deng L et al. Mol Biol Cell 2013 Jun;24(12):1872-81

PMID:34523683 - Cdc42 reactivation at growth sites is regulated by local cell-cycle-dependent loss of its GTPase-activating protein Rga4 in fission yeast.

Rich-Robinson J et al. J Cell Sci 2021 Oct 01;134(19)

PMID:34666001 - Detection of surface forces by the cell-wall mechanosensor Wsc1 in yeast.

Neeli-Venkata R et al. Dev Cell 2021 Oct 25;56(20):2856-2870.e7

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

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PMID:25837586 - Spontaneous Cdc42 polarization independent of GDI-mediated extraction and actin-based trafficking.

Bendezú FO et al. PLoS Biol 2015 Apr;13(4):e1002097

PMID:39110593 - VAP-mediated membrane-tethering mechanisms implicate ER-PM contact function in pH homeostasis.

Hoh KL et al. Cell Rep 2024 Aug 05;43(8):114592

PMID:29689193 - Mechanosensation Dynamically Coordinates Polar Growth and Cell Wall Assembly to Promote Cell Survival.

Davì V et al. Dev Cell 2018 Apr 23;45(2):170-182.e7

PMID:17085965 - Function of rax2p in the polarized growth of fission yeast.

Choi E et al. Mol Cells 2006 Oct 31;22(2):146-53

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:14596912 - The protein kinase kin1, the fission yeast orthologue of mammalian MARK/PAR-1, localises to new cell ends after mitosis and is important for bipolar growth.

Drewes G et al. FEBS Lett 2003 Nov 06;554(1-2):45-9

PMID:11972773 - The p21-activated kinase, Shk1, is required for proper regulation of microtubule dynamics in the fission yeast, Schizosaccharomyces pombe.

Qyang Y et al. Mol Microbiol 2002 Apr;44(2):325-34

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:40187481 - Where to grow and where to go.

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PMID:11950884 - Different mechanisms of cell polarisation in vegetative and shmooing growth in fission yeast.

Niccoli T et al. J Cell Sci 2002 Apr 15;115(Pt 8):1651-62

PMID:9200612 - tea1 and the microtubular cytoskeleton are important for generating global spatial order within the fission yeast cell.

Mata J et al. Cell 1997 Jun 13;89(6):939-49

PMID:10503548 - Analysis of the cps1 gene provides evidence for a septation checkpoint in Schizosaccharomyces pombe.

Le Goff X et al. Mol Gen Genet 1999 Aug;262(1):163-72

PMID:19597328 - Role of the protein kinase Kin1 and nuclear centering in actomyosin ring formation in fission yeast.

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PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

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PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

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PMID:8522609 - Fission yeast cell morphogenesis: identification of new genes and analysis of their role during the cell cycle.

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PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

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PMID:9679144 - Regulation of cell polarity by microtubules in fission yeast.

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PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:25422470 - Oscillatory AAA+ ATPase Knk1 constitutes a novel morphogenetic pathway in fission yeast.

Scheffler K et al. Proc Natl Acad Sci U S A 2014 Dec 16;111(50):17899-904

PMID:11516644 - Role of bud6p and tea1p in the interaction between actin and microtubules for the establishment of cell polarity in fission yeast.

Glynn JM et al. Curr Biol 2001 Jun 05;11(11):836-45

PMID:22918943 - Anillin-related protein Mid1p coordinates the assembly of the cytokinetic contractile ring in fission yeast.

Saha S et al. Mol Biol Cell 2012 Oct;23(20):3982-92

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:15772152 - Effects of {gamma}-tubulin complex proteins on microtubule nucleation and catastrophe in fission yeast.

Zimmerman S et al. Mol Biol Cell 2005 Jun;16(6):2719-33

PMID:18328707 - Pom1 DYRK regulates localization of the Rga4 GAP to ensure bipolar activation of Cdc42 in fission yeast.

Tatebe H et al. Curr Biol 2008 Mar 11;18(5):322-30

PMID:24554432 - The Tea4-PP1 landmark promotes local growth by dual Cdc42 GEF recruitment and GAP exclusion.

Kokkoris K et al. J Cell Sci 2014 May 01;127(Pt 9):2005-16

PMID:12789340 - Fission yeast mod5p regulates polarized growth through anchoring of tea1p at cell tips.

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PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

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PMID:23222840 - Centrosomal MPF triggers the mitotic and morphogenetic switches of fission yeast.

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PMID:21511999 - Comparative functional genomics of the fission yeasts.

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PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.

Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480

PMID:23041194 - Plasma membrane tethering of the cortical ER necessitates its finely reticulated architecture.

Zhang D et al. Curr Biol 2012 Nov 06;22(21):2048-52

PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99

PMID:15797925 - The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast.

Pardo M et al. J Cell Sci 2005 Apr 15;118(Pt 8):1705-14