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protein coding gene - nad1 (SPCC1235.04c) - FAD synthetase Nad1

Gene summary

Standard name
nad1
Systematic ID
SPCC1235.04c
Product
FAD synthetase Nad1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74841
ORFeome ID
12/12C09
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 180697..182275 reverse strand

Annotation

PBO:0005037 - 2.7.7.2

Disease association

MONDO:0009703 - myopathy with abnormal lipid metabolism

References:

GO biological process

GO:0006747 - FAD biosynthetic process

References:

GO:0046444 - FMN metabolic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005739 - mitochondrion

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0003919 - FMN adenylyltransferase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01507PAPS_reductPAPS_reduct_domPfam
cd23948FAD_synthaseCDD
G3DSA:3.40.50.620:FF:000187CATH-FunFam
G3DSA:3.40.50.620Rossmann-like_a/b/a_foldCATH-Gene3D
SSF52402SUPERFAMILY
PTHR23293PANTHER

Orthologs

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.
Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36