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protein coding gene - sec6 (SPCC1235.10c) - exocyst complex subunit Exo3

Gene summary

Standard name
sec6
Systematic ID
SPCC1235.10c
Product
exocyst complex subunit Exo3
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
exo3
UniProt ID
O74846
ORFeome ID
29/29B04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 196513..199369 reverse strand

Annotation

GO biological process

GO:0006887 - exocytosis

References:

GO cellular component

GO:0051285 - cell cortex of cell tip

References:

GO:1902716 - cell cortex of growing cell tip

References:

GO:0032153 - cell division site

References:

GO:0051286 - cell tip

References:

GO:0090726 - cortical dynamic polarity patch

References:

GO:0000145 - exocyst

References:

GO:0097575 - lateral cell cortex

References:

GO:1990819 - mating projection actin fusion focus

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0005515 - protein binding

References:

GO:0000149 - SNARE binding

References:

GO:7770062 - vesicle membrane tethering activity

References:

Multi-locus phenotype

FYPO:0007689 - normal cell growth polarization

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001042 - inviable after spore germination, single or double cell division

References:

Genotypes:

FYPO:0000313 - inviable after spore germination, without cell division, with abnormal germ tube morphology

References:

Genotypes:

FYPO:0006556 - inviable elongated tetranucleate triseptate vegetative cell, single septa between nuclei

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0007689 - normal cell growth polarization

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF06046Sec6EXOC3/Sec6Pfam
G3DSA:1.10.357.50CATH-Gene3D
G3DSA:1.10.357.70EXOC3/Sec6_CCATH-Gene3D
PTHR21292EXOC3/Sec6PANTHER

Orthologs

References / Literature

PMID:23200991 - Cdc42 explores the cell periphery for mate selection in fission yeast.
Bendezú FO et al. Curr Biol 2013 Jan 07;23(1):42-7
PMID:11854409 - The multiprotein exocyst complex is essential for cell separation in Schizosaccharomyces pombe.
Wang H et al. Mol Biol Cell 2002 Feb;13(2):515-29
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:29290560 - ER-PM Contacts Restrict Exocytic Sites for Polarized Morphogenesis.
Ng AYE et al. Curr Biol 2018 Jan 08;28(1):146-153.e5
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24947517 - The putative exchange factor Gef3p interacts with Rho3p GTPase and the septin ring during cytokinesis in fission yeast.
Muñoz S et al. J Biol Chem 2014 Aug 08;289(32):21995-2007
PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.
Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99
PMID:25724972 - Rho4 interaction with exocyst and septins regulates cell separation in fission yeast.
Pérez P et al. Microbiology (Reading) 2015 May;161(Pt 5):948-959
PMID:41171630 - Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis.
Singh D et al. Elife 2025 Oct 31;13
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:41335110 - High-resolution mapping of the actin fusion focus reveals myosin V-dependent formin transport for aster formation.
Thomas V et al. J Cell Biol 2026 Feb 02;225(2)
PMID:21148300 - Actin cables and the exocyst form two independent morphogenesis pathways in the fission yeast.
Bendezú FO et al. Mol Biol Cell 2011 Jan 01;22(1):44-53
PMID:41855172 - Distinct Cdc42 protein levels differentially regulate polarized growth and cell fusion in Schizosaccharomyces pombe.
Saha S et al. PLoS Biol 2026 Mar;24(3):e3003712
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24146635 - Hsp70-Hsp40 chaperone complex functions in controlling polarized growth by repressing Hsf1-driven heat stress-associated transcription.
Vjestica A et al. PLoS Genet 2013;9(10):e1003886
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference