protein coding gene - ght5 (SPCC1235.14) - plasma membrane high-affinity glucose/fructose:proton symporter Ght5

Gene summary

Standard name

ght5

Systematic ID

SPCC1235.14

Product

plasma membrane high-affinity glucose/fructose:proton symporter Ght5

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P78831

ORFeome ID

34/34E03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 212313..214376 forward strand

Annotation

Protein features

Orthologs

• SJAG_03608 Schizosaccharomyces japonicus
• HXT15 (YDL245C) Saccharomyces cerevisiae
• HXT7 (YDR342C) Saccharomyces cerevisiae
• HXT6 (YDR343C) Saccharomyces cerevisiae
• STL1 (YDR536W) Saccharomyces cerevisiae
• HXT13 (YEL069C) Saccharomyces cerevisiae
• MAL11 (YGR289C) Saccharomyces cerevisiae
• HXT4 (YHR092C) Saccharomyces cerevisiae
• HXT1 (YHR094C) Saccharomyces cerevisiae
• HXT5 (YHR096C) Saccharomyces cerevisiae
• HXT8 (YJL214W) Saccharomyces cerevisiae
• HXT9 (YJL219W) Saccharomyces cerevisiae
• HXT16 (YJR158W) Saccharomyces cerevisiae
• GAL2 (YLR081W) Saccharomyces cerevisiae
• HXT2 (YMR011W) Saccharomyces cerevisiae
• HXT14 (YNL318C) Saccharomyces cerevisiae
• HXT17 (YNR072W) Saccharomyces cerevisiae
• HXT11 (YOL156W) Saccharomyces cerevisiae

References / Literature

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Schwer B et al. mBio 2024 Jun 20;:e0125224

PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:34980915 - SignalP 6.0 predicts all five types of signal peptides using protein language models.

Teufel F et al. Nat Biotechnol 2022 Jul;40(7):1023-1025

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:10735857 - Multiple hexose transporters of Schizosaccharomyces pombe.

Heiland S et al. J Bacteriol 2000 Apr;182(8):2153-62

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:36990657 - Iron affects localization of Ght5 in fission yeast.

Akyüz SN et al. FEMS Microbiol Lett 2023 Jan 17;370

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:9090050 - Properties and heterologous expression of the glucose transporter GHT1 from Schizosaccharomyces pombe.

Lichtenberg-Fraté H et al. Yeast 1997 Mar 15;13(3):215-24

PMID:34028542 - TORC2 inhibition of α-arrestin Aly3 mediates cell surface persistence of S. pombe Ght5 glucose transporter in low glucose.

Toyoda Y et al. J Cell Sci 2021 May 15;134(10)

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.

Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:39747188 - PhpC NF-Y transcription factor infiltrates heterochromatin to generate cryptic intron-containing transcripts crucial for small RNA production.

Srivastav MK et al. Nat Commun 2025 Jan 02;16(1):268

PMID:42030144 - Gene loss, repression, amplification, and horizontal acquisition shape galactose/melibiose metabolism in fission yeast.

Du XM et al. Proc Natl Acad Sci U S A 2026 Apr 28;123(17):e2532532123

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:8000531 - Glucose-transport-deficient mutants of Schizosaccharomyces pombe: phenotype, genetics and use for genetic complementation.

Milbradt B et al. Microbiology (Reading) 1994 Oct;140 ( Pt 10):2617-23

PMID:34805795 - The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability.

Calvo IA et al. iScience 2021 Nov 19;24(11):103338

PMID:23254763 - Ght2⁺ is required for UDP-galactose synthesis from extracellular galactose by Schizosaccharomyces pombe.

Matsuzawa T et al. Appl Microbiol Biotechnol 2013 Jun;97(11):4957-64

GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.

PMID:35416247 - Tschimganine has different targets for chronological lifespan extension and growth inhibition in fission yeast.

Ohtsuka H et al. Biosci Biotechnol Biochem 2022 May 24;86(6):775-779

PMID:28108582 - Identification of a novel protein kinase that affects the chronological lifespan in fission yeast.

Kurauchi T et al. FEMS Microbiol Lett 2017 Jan;364(2)

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:30072439 - The putative ceramide-conjugation protein Cwh43 regulates G0 quiescence, nutrient metabolism and lipid homeostasis in fission yeast.

Nakazawa N et al. J Cell Sci 2018 Aug 21;131(16)

PMID:34460892 - Transcriptome sequencing and screening of genes related to glucose availability in Schizosaccharomyces pombe by RNA-seq analysis.

Tarhan Ç et al. Genet Mol Biol 2021;44(3):e20200245

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:25411338 - Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.

Saitoh S et al. Mol Biol Cell 2015 Jan 15;26(2):373-86

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:30782292 - Hydrogen peroxide-induced oxidative stress upregulates ght5 gene belonging to hexose transporters in Schizosaccharomyces pombe.

Kına UY et al. Cell Mol Biol (Noisy-le-grand) 2019 Jan 31;65(1):41-45

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:30730059 - Iron regulates hexose transporters in Schizosaccharomyces pombe.

Özkan E et al. J Basic Microbiol 2019 May;59(5):458-464

PMID:35286199 - Mitotic spindle formation in the absence of Polo kinase.

Kim J et al. Proc Natl Acad Sci U S A 2022 Mar 22;119(12):e2114429119

PMID:26896847 - Ensembl comparative genomics resources.

Herrero J et al. Database (Oxford) 2016;2016

PMID:35781263 - Characterization of hexose transporter genes in the views of the chronological life span and glucose uptake in fission yeast.

Maruyama T et al. J Gen Appl Microbiol 2023 Mar 06;68(6):270-277

PMID:36820394 - Inorganic polyphosphate abets silencing of a sub-telomeric gene cluster in fission yeast.

Sanchez AM et al. MicroPubl Biol 2023;2023

PMID:22235339 - The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia.

Lando D et al. PLoS One 2012;7(1):e29765

PMID:38133430 - Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP 6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast.

Bednor L et al. mBio 2023 Dec 22;:e0306223

PMID:36882296 - Duf89 abets lncRNA control of fission yeast phosphate homeostasis via its antagonism of precocious lncRNA transcription termination.

Sanchez AM et al. RNA 2023 Jun;29(6):808-825