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protein coding gene - rps1802 (SPCC1259.01c) - 40S ribosomal protein S18

Gene summary

Standard name
rps1802
Systematic ID
SPCC1259.01c
Product
40S ribosomal protein S18
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
rps18-2, SPCC825.06c
UniProt ID
P0CT67
ORFeome ID
05/05B04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1032876..1033481 reverse strand

Annotation

GO biological process

GO:0002181 - cytoplasmic translation

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GO cellular component

GO:0005737 - cytoplasm

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GO:0005829 - cytosol

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GO:0022627 - cytosolic small ribosomal subunit

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GO:0005634 - nucleus

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GO molecular function

GO:0019843 - rRNA binding

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GO:0003735 - structural constituent of ribosome

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:01149 - sumoylated lysine

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000027 - ribosomal density decreased

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PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001117 - decreased RNA level during vegetative growth

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Genotypes:

FYPO:0000340 - haploinsufficient

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Genotypes:

FYPO:0002317 - increased cellular squalene level

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Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

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Genotypes:

FYPO:0007559 - normal growth on diethylstilbestrol

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Genotypes:

FYPO:0007558 - normal growth on econazole

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Genotypes:

FYPO:0000962 - normal growth on hydrogen peroxide

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Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

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Genotypes:

FYPO:0000979 - normal growth on miconazole

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Genotypes:

FYPO:0002343 - normal growth on terbinafine

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Genotypes:

FYPO:0007557 - normal growth on tolnaftate

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Genotypes:

FYPO:0001701 - sensitive to bortezomib

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0007556 - sensitive to diethylstilbestrol

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Genotypes:

FYPO:0007555 - sensitive to econazole

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

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Genotypes:

FYPO:0003358 - sensitive to miconazole

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Genotypes:

FYPO:0002328 - sensitive to terbinafine

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Genotypes:

FYPO:0007554 - sensitive to tolnaftate

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002476 - viable vacuolated vegetative cell, abnormal cell shape, normal cell size

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00416Ribosomal_S13Ribosomal_uS13PFAM
PS00646RIBOSOMAL_S13_1Ribosomal_uS13_CSPROSITE_PATTERNS
PS50159RIBOSOMAL_S13_2PROSITE_PROFILES
G3DSA:4.10.910.10:FF:000002FUNFAM
G3DSA:1.10.8.50:FF:000002FUNFAM
SSF46946S13-like H2TH domainRibosomal_uS13-like_H2THSUPERFAMILY
G3DSA:4.10.910.1030s ribosomal protein s13, domain 2Rbsml_uS13_CGENE3D
G3DSA:1.10.8.50GENE3D
PTHR1087130S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18PANTHER
PIRSF002134RPS13p_RPS13a_RPS18e_RPS13oRibosomal_uS13PIRSF
MF_01315Ribosomal_uS13Ribosomal_uS13HAMAP
NF003140PRK04053.1NCBIFAM

Orthologs

References / Literature

PMID:39379376 - Ribosomes hibernate on mitochondria during cellular stress.
Gemin O et al. Nat Commun 2024 Oct 08;15(1):8666
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:26404184 - High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.
Nie M et al. Sci Rep 2015 Sep 25;5:14389
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:39358553 - Ageing-associated long non-coding RNA extends lifespan and reduces translation in non-dividing cells.
Anver S et al. EMBO Rep 2024 Oct 02;
PMID:18600047 - Genome-wide identification of haploinsufficiency in fission yeast.
Baek ST et al. J Microbiol Biotechnol 2008 Jun;18(6):1059-63
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183
PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .
Wiley DJ et al. Front Physiol 2020;11:427
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:38269097 - Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology.
Morozumi Y et al. iScience 2024 Jan 19;27(1):108777
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.
Takeda K et al. PLoS One 2011;6(7):e22021
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:33223513 - Systematic Target Screening Revealed That Tif302 Could Be an Off-Target of the Antifungal Terbinafine in Fission Yeast.
Lee S et al. Biomol Ther (Seoul) 2021 Mar 01;29(2):234-247
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20403971 - Proteomic and functional analysis of the noncanonical poly(A) polymerase Cid14.
Keller C et al. RNA 2010 Jun;16(6):1124-9
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;