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protein coding gene - taf8 (SPCC1259.06) - transcription factor TFIID complex histone fold subunit Taf8

Gene summary

Standard name
taf8
Systematic ID
SPCC1259.06
Product
transcription factor TFIID complex histone fold subunit Taf8
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94706
ORFeome ID
08/08F05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1043603..1044997 forward strand

Annotation

Disease association

MONDO:0859266 - neurodevelopmental disorder with severe motor impairment, absent language, cerebral hypomyelination, and brain atrophy

References:

GO biological process

GO:0006367 - transcription initiation at RNA polymerase II promoter

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GO cellular component

GO:0005669 - transcription factor TFIID complex

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GO molecular function

GO:0016251 - RNA polymerase II general transcription initiation factor activity

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Modification

MOD:00046 - O-phospho-L-serine

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Protein features

PBO:0111763 - histone fold

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF10406TAF8_CTFIID_su8_CPfam
cd00076HFD_SFCDD
cd08049TAF8TFIID_su8_CCDD
G3DSA:1.10.20.10Histone-foldCATH-Gene3D
PTHR46469TAF8PANTHER

Orthologs

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:19913479 - Cryo-EM reveals promoter DNA binding and conformational flexibility of the general transcription factor TFIID.
Elmlund H et al. Structure 2009 Nov 11;17(11):1442-52
PMID:8303296 - RNA polymerase II initiation factor interactions and transcription start site selection.
Li Y et al. Science 1994 Feb 11;263(5148):805-7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:29079657 - TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.
Laboucarié T et al. EMBO Rep 2017 Dec;18(12):2197-2218