protein coding gene - chk1 (SPCC1259.13) - Chk1 protein kinase

Gene summary

Standard name

chk1

Systematic ID

SPCC1259.13

Product

Chk1 protein kinase

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

rad27

UniProt ID

P34208

ORFeome ID

45/45G09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 1059796..1064443 forward strand

Annotation

Protein features

Orthologs

• CHEK1 (HGNC:1925) Homo sapiens
• chk1 (SJAG_01680) Schizosaccharomyces japonicus
• CHK1 (YBR274W) Saccharomyces cerevisiae

References / Literature

PMID:29784772 - A Heterochromatin Domain Forms Gradually at a New Telomere and Is Dynamic at Stable Telomeres.

Wang J et al. Mol Cell Biol 2018 Aug 01;38(15)

PMID:10588638 - Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints.

Shimada M et al. Mol Biol Cell 1999 Dec;10(12):3991-4003

PMID:11553781 - Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast.

Lopez-Girona A et al. Proc Natl Acad Sci U S A 2001 Sep 25;98(20):11289-94

PMID:10825192 - Mechanism of caffeine-induced checkpoint override in fission yeast.

Moser BA et al. Mol Cell Biol 2000 Jun;20(12):4288-94

PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.

Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813

PMID:18675827 - The tumor suppressor homolog in fission yeast, myh1(+), displays a strong interaction with the checkpoint gene rad1(+).

Jansson K et al. Mutat Res 2008 Sep 26;644(1-2):48-55

PMID:16478984 - The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.

Pebernard S et al. Mol Cell Biol 2006 Mar;26(5):1617-30

PMID:15466421 - A screen for Schizosaccharomyces pombe mutants defective in rereplication identifies new alleles of rad4+, cut9+ and psf2+.

Gómez EB et al. Genetics 2005 Jan;169(1):77-89

PMID:21095590 - DDK phosphorylates checkpoint clamp component Rad9 and promotes its release from damaged chromatin.

Furuya K et al. Mol Cell 2010 Nov 24;40(4):606-18

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:12514100 - Checkpoint activation regulates mutagenic translesion synthesis.

Kai M et al. Genes Dev 2003 Jan 01;17(1):64-76

PMID:23322785 - The fission yeast minichromosome maintenance (MCM)-binding protein (MCM-BP), Mcb1, regulates MCM function during prereplicative complex formation in DNA replication.

Santosa V et al. J Biol Chem 2013 Mar 08;288(10):6864-80

PMID:16816416 - Antagonism of Chk1 signaling in the G2 DNA damage checkpoint by dominant alleles of Cdr1.

Calonge TM et al. Genetics 2006 Sep;174(1):113-23

PMID:19546237 - TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.

Schonbrun M et al. Mol Cell Biol 2009 Aug;29(16):4584-94

PMID:15767681 - Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage.

Sommariva E et al. Mol Cell Biol 2005 Apr;25(7):2770-84

PMID:16849602 - Regulation of DNA replication machinery by Mrc1 in fission yeast.

Nitani N et al. Genetics 2006 Sep;174(1):155-65

PMID:11711540 - The Ded1 DEAD box helicase interacts with Chk1 and Cdc2.

Liu HY et al. J Biol Chem 2002 Jan 25;277(4):2637-43

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:25552606 - Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.

Chen JS et al. G3 (Bethesda) 2014 Dec 31;5(3):361-70

PMID:9372918 - Role of Schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage tolerance.

Murray JM et al. Mol Cell Biol 1997 Dec;17(12):6868-75

PMID:29622660 - RNase H eliminates R-loops that disrupt DNA replication but is nonessential for efficient DSB repair.

Zhao H et al. EMBO Rep 2018 May;19(5)

PMID:9042863 - Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast.

Rhind N et al. Genes Dev 1997 Feb 15;11(4):504-11

PMID:10888871 - Mitotic replication initiation proteins are not required for pre-meiotic S phase.

Forsburg SL et al. Nat Genet 2000 Jul;25(3):263-8

PMID:11416129 - Schizosaccharomyces pombe cells lacking the amino-terminal catalytic domains of DNA polymerase epsilon are viable but require the DNA damage checkpoint control.

Feng W et al. Mol Cell Biol 2001 Jul;21(14):4495-504

PMID:12081644 - Fission yeast chk1 mutants show distinct responses to different types of DNA damaging treatments.

Francesconi S et al. Genes Cells 2002 Jul;7(7):663-73

PMID:33723569 - Schizosaccharomyces pombe KAT5 contributes to resection and repair of a DNA double-strand break.

Li T et al. Genetics 2021 May 17;218(1)

PMID:16354704 - Rhp51-dependent recombination intermediates that do not generate checkpoint signal are accumulated in Schizosaccharomyces pombe rad60 and smc5/6 mutants after release from replication arrest.

Miyabe I et al. Mol Cell Biol 2006 Jan;26(1):343-53

PMID:31262821 - Replication fork stalling elicits chromatin compaction for the stability of stalling replication forks.

Feng G et al. Proc Natl Acad Sci U S A 2019 Jul 16;116(29):14563-14572

PMID:9092625 - Characterisation of Schizosaccharomyces pombe rad31, a UBA-related gene required for DNA damage tolerance.

Shayeghi M et al. Nucleic Acids Res 1997 Mar 15;25(6):1162-9

PMID:9870697 - Differential effects of caffeine on DNA damage and replication cell cycle checkpoints in the fission yeast Schizosaccharomyces pombe.

Osman F et al. Mol Gen Genet 1998 Nov;260(4):319-34

PMID:18183307 - Importance of a C-terminal conserved region of Chk1 for checkpoint function.

Palermo C et al. PLoS One 2008 Jan 09;3(1):e1427

PMID:16371652 - Production of reactive oxygen species in response to replication stress and inappropriate mitosis in fission yeast.

Marchetti MA et al. J Cell Sci 2006 Jan 01;119(Pt 1):124-31

PMID:21098121 - Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation.

Takahashi K et al. Mol Cell Biol 2011 Feb;31(3):495-506

PMID:22064477 - The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast.

Groocock LM et al. Mol Cell Biol 2012 Jan;32(2):276-87

PMID:27585850 - Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α-Demethylase in the Ergosterol Biosynthesis Pathway.

Xu YJ et al. Genetics 2016 Nov;204(3):959-973

PMID:9487130 - Regulation of telomere length by checkpoint genes in Schizosaccharomyces pombe.

Dahlen M et al. Mol Biol Cell 1998 Mar;9(3):611-21

PMID:24074952 - Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4(TopBP1).

Qu M et al. Mol Cell 2013 Sep 26;51(6):723-736

PMID:25372384 - The MluI cell cycle box (MCB) motifs, but not damage-responsive elements (DREs), are responsible for the transcriptional induction of the rhp51+ gene in response to DNA replication stress.

Sartagul W et al. PLoS One 2014;9(11):e111936

PMID:11160827 - Role of fission yeast primase catalytic subunit in the replication checkpoint.

Griffiths DJ et al. Mol Biol Cell 2001 Jan;12(1):115-28

PMID:22927644 - Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant.

Sánchez A et al. Mol Cell Biol 2012 Nov;32(21):4445-54

PMID:29851556 - Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1.

Limbo O et al. Mol Biol Cell 2018 Jun 01;29(11):1389-1399

PMID:18180284 - Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote s-phase genome stability.

Bailis JM et al. Mol Cell Biol 2008 Mar;28(5):1724-38

PMID:15805471 - Ddb1 controls genome stability and meiosis in fission yeast.

Holmberg C et al. Genes Dev 2005 Apr 01;19(7):853-62

PMID:11073995 - Rdp1, a novel zinc finger protein, regulates the DNA damage response of rhp51(+) from Schizosaccharomyces pombe.

Shim YS et al. Mol Cell Biol 2000 Dec;20(23):8958-68

PMID:9928931 - The S/M checkpoint at 37 degrees C and the recovery of viability of the mutant poldeltats3 require the crb2+/rhp9+ gene in fission yeast.

Grenon M et al. Mol Gen Genet 1999 Jan;260(6):522-34

PMID:24586893 - Wat1/pop3, a conserved WD repeat containing protein acts synergistically with checkpoint kinase Chk1 to maintain genome ploidy in fission yeast S. pombe.

Verma SK et al. PLoS One 2014;9(2):e89587

PMID:11313465 - Threonine-11, phosphorylated by Rad3 and atm in vitro, is required for activation of fission yeast checkpoint kinase Cds1.

Tanaka K et al. Mol Cell Biol 2001 May;21(10):3398-404

PMID:17936710 - Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination.

Limbo O et al. Mol Cell 2007 Oct 12;28(1):134-46

PMID:25269894 - Fission yeast Drp1 is an essential protein required for recovery from DNA damage and chromosome segregation.

Ranjan R et al. DNA Repair (Amst) 2014 Dec;24:98-106

PMID:18378696 - Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex.

Akamatsu Y et al. Mol Cell Biol 2008 Jun;28(11):3639-51

PMID:17660542 - Mms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe.

Dovey CL et al. Genetics 2007 Sep;177(1):47-61

PMID:22036784 - Purification and functional inactivation of the fission yeast MCM(MCM-BP) complex.

Li JJ et al. FEBS Lett 2011 Dec 15;585(24):3850-5

PMID:27473316 - Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.

Ranatunga NS et al. G3 (Bethesda) 2016 Oct 13;6(10):3049-3063

PMID:10683155 - A novel mutant allele of the chromatin-bound fission yeast checkpoint protein Rad17 separates the DNA structure checkpoints.

Griffiths D et al. J Cell Sci 2000 Mar;113 ( Pt 6):1075-88

PMID:26093291 - Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in Schizosaccharomyces pombe.

Habib AG et al. Biochem Biophys Res Commun 2015 Aug 14;464(1):140-6

PMID:9407031 - Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.

Saka Y et al. Genes Dev 1997 Dec 15;11(24):3387-400

PMID:19250904 - Regulation of Set9-mediated H4K20 methylation by a PWWP domain protein.

Wang Y et al. Mol Cell 2009 Feb 27;33(4):428-37

PMID:12960401 - Intra-G1 arrest in response to UV irradiation in fission yeast.

Nilssen EA et al. Proc Natl Acad Sci U S A 2003 Sep 16;100(19):10758-63

PMID:31719112 - Checkpoint Regulation of Nuclear Tos4 Defines S Phase Arrest in Fission Yeast.

Kim SM et al. G3 (Bethesda) 2020 Jan 07;10(1):255-266

PMID:11270571 - A novel genetic screen identifies checkpoint-defective alleles of Schizosaccharomyces pombe chk1.

Wan S et al. Curr Genet 2001 Jan;38(6):299-306

PMID:18414064 - Schizosaccharomyces pombe Orc5 plays multiple roles in the maintenance of genome stability throughout the cell cycle.

Kato H et al. Cell Cycle 2008 Apr 15;7(8):1085-96

PMID:15367656 - Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.

Noguchi E et al. Mol Cell Biol 2004 Oct;24(19):8342-55

PMID:28903048 - Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription.

Pai CC et al. Cell Rep 2017 Sep 12;20(11):2693-2705

PMID:14765108 - Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1.

den Elzen NR et al. EMBO J 2004 Feb 25;23(4):908-18

PMID:25293972 - Increased meiotic crossovers and reduced genome stability in absence of Schizosaccharomyces pombe Rad16 (XPF).

Mastro TL et al. Genetics 2014 Dec;198(4):1457-72

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:9135148 - p56(chk1) protein kinase is required for the DNA replication checkpoint at 37 degrees C in fission yeast.

Francesconi S et al. EMBO J 1997 Mar 17;16(6):1332-41

PMID:17189249 - Tel2 is required for activation of the Mrc1-mediated replication checkpoint.

Shikata M et al. J Biol Chem 2007 Feb 23;282(8):5346-55

PMID:29123917 - The telomere bouquet facilitates meiotic prophase progression and exit in fission yeast.

Moiseeva V et al. Cell Discov 2017;3:17041

PMID:12186947 - A novel chk1-dependent G1/M checkpoint in fission yeast.

Synnes M et al. J Cell Sci 2002 Sep 15;115(Pt 18):3609-18

PMID:11809834 - Fission yeast F-box protein Pof3 is required for genome integrity and telomere function.

Katayama S et al. Mol Biol Cell 2002 Jan;13(1):211-24

PMID:21971174 - Abundance of prereplicative complexes (Pre-RCs) facilitates recombinational repair under replication stress in fission yeast.

Maki K et al. J Biol Chem 2011 Dec 02;286(48):41701-41710

PMID:26368543 - Critical Function of γH2A in S-Phase.

Mejia-Ramirez E et al. PLoS Genet 2015 Sep;11(9):e1005517

PMID:11027257 - Analysis of fission yeast primase defines the checkpoint responses to aberrant S phase initiation.

Tan S et al. Mol Cell Biol 2000 Nov;20(21):7853-66

PMID:27098497 - CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection.

Zeng M et al. Nat Commun 2016 Apr 21;7:11364

PMID:9914167 - Reduced dosage of a single fission yeast MCM protein causes genetic instability and S phase delay.

Liang DT et al. J Cell Sci 1999 Feb;112 ( Pt 4):559-67

PMID:10407262 - The topoisomerase I poison camptothecin generates a Chk1-dependent DNA damage checkpoint signal in fission yeast.

Wan S et al. Yeast 1999 Jul;15(10A):821-8

PMID:10512862 - Requirement of sequences outside the conserved kinase domain of fission yeast Rad3p for checkpoint control.

Chapman CR et al. Mol Biol Cell 1999 Oct;10(10):3223-38

PMID:15155581 - Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1.

Furuya K et al. Genes Dev 2004 May 15;18(10):1154-64

PMID:12810074 - A fission yeast homologue of the human uracil-DNA-glycosylase and their roles in causing DNA damage after overexpression.

Elder RT et al. Biochem Biophys Res Commun 2003 Jul 04;306(3):693-700

PMID:17151242 - Sap1 promotes the association of the replication fork protection complex with chromatin and is involved in the replication checkpoint in Schizosaccharomyces pombe.

Noguchi C et al. Genetics 2007 Feb;175(2):553-66

PMID:24587136 - The oxidative stress responsive transcription factor Pap1 confers DNA damage resistance on checkpoint-deficient fission yeast cells.

Belfield C et al. PLoS One 2014;9(2):e89936

PMID:25533348 - Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability.

Caetano C et al. Cell Rep 2014 Dec 24;9(6):2279-89

PMID:9154838 - A ubiquitin-conjugating enzyme in fission yeast that is essential for the onset of anaphase in mitosis.

Osaka F et al. Mol Cell Biol 1997 Jun;17(6):3388-97

PMID:24478458 - The checkpoint-dependent nuclear accumulation of Rho1p exchange factor Rgf1p is important for tolerance to chronic replication stress.

Muñoz S et al. Mol Biol Cell 2014 Apr;25(7):1137-50

PMID:12196391 - Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.

Nakamura TM et al. Genetics 2002 Aug;161(4):1437-52

PMID:22730331 - Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Nie M et al. J Biol Chem 2012 Aug 24;287(35):29610-9

PMID:20967229 - Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast.

Rapp JB et al. PLoS One 2010 Oct 12;5(10):e13379

PMID:39789818 - SRPKs Homolog Dsk1 Regulates Homologous Recombination Repair in Schizosaccharomyces pombe.

Lu G et al. Genes Cells 2025 Jan;30(1):e13192

PMID:9398669 - A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes.

Yamaguchi S et al. Mol Biol Cell 1997 Dec;8(12):2475-86

PMID:31260531 - Gcn5-mediated acetylation at MBF-regulated promoters induces the G1/S transcriptional wave.

González-Medina A et al. Nucleic Acids Res 2019 Sep 19;47(16):8439-8451

PMID:29092815 - The kinase domain residue serine 173 of S chizosaccharomyce s pombe Chk1 kinase is critical for the response to DNA replication stress.

Coulton N et al. Biol Open 2017 Dec 15;6(12):1840-1850

PMID:22682874 - Sensor and effector kinases in DNA damage checkpoint regulate capacity for homologous recombination repair of fission yeast in G2 phase.

Yasuhira S et al. DNA Repair (Amst) 2012 Aug 01;11(8):666-75

PMID:26746798 - Inner nuclear membrane protein Lem2 facilitates Rad3-mediated checkpoint signaling under replication stress induced by nucleotide depletion in fission yeast.

Xu YJ Cell Signal 2016 Apr;28(4):235-45

PMID:17690116 - Cdc18/CDC6 activates the Rad3-dependent checkpoint in the fission yeast.

Fersht N et al. Nucleic Acids Res 2007;35(16):5323-37

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:21813639 - Schizosaccharomyces pombe minichromosome maintenance-binding protein (MCM-BP) antagonizes MCM helicase.

Ding L et al. J Biol Chem 2011 Sep 23;286(38):32918-30

PMID:8036497 - 14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast.

Ford JC et al. Science 1994 Jul 22;265(5171):533-5

PMID:19185548 - The role of novel genes rrp1(+) and rrp2(+) in the repair of DNA damage in Schizosaccharomyces pombe.

Dziadkowiec D et al. DNA Repair (Amst) 2009 May 01;8(5):627-36

PMID:24806966 - The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins.

Tsang E et al. J Cell Sci 2014 Jul 01;127(Pt 13):2983-94

PMID:39387272 - The DNA Damage Repair Function of Fission Yeast CK1 Involves Targeting Arp8, a Subunit of the INO80 Chromatin Remodeling Complex.

Cullati SN et al. Mol Cell Biol 2024 Oct 10;:1-15

PMID:10757807 - Cid1, a fission yeast protein required for S-M checkpoint control when DNA polymerase delta or epsilon is inactivated.

Wang SW et al. Mol Cell Biol 2000 May;20(9):3234-44

PMID:9278510 - Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase.

Furnari B et al. Science 1997 Sep 05;277(5331):1495-7

PMID:15548596 - Analysis of mutant phenotypes and splicing defects demonstrates functional collaboration between the large and small subunits of the essential splicing factor U2AF in vivo.

Webb CJ et al. Mol Biol Cell 2005 Feb;16(2):584-96

PMID:12930957 - Nuclear factories for signalling and repairing DNA double strand breaks in living fission yeast.

Meister P et al. Nucleic Acids Res 2003 Sep 01;31(17):5064-73

PMID:25793410 - Suppression of sensitivity to drugs and antibiotics by high external cation concentrations in fission yeast.

Alao JP et al. PLoS One 2015;10(3):e0119297

PMID:15329725 - Separase-mediated cleavage of cohesin at interphase is required for DNA repair.

Nagao K et al. Nature 2004 Aug 26;430(7003):1044-8

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:31332096 - A tel2 Mutation That Destabilizes the Tel2-Tti1-Tti2 Complex Eliminates Rad3 ATR Kinase Signaling in the DNA Replication Checkpoint and Leads to Telomere Shortening in Fission Yeast.

Xu YJ et al. Mol Cell Biol 2019 Oct 15;39(20)

PMID:28640807 - Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase.

Boronat S et al. PLoS Genet 2017 Jun;13(6):e1006858

PMID:23195958 - Anaphase-promoting complex/cyclosome-mediated proteolysis of Ams2 in the G1 phase ensures the coupling of histone gene expression to DNA replication in fission yeast.

Trickey M et al. J Biol Chem 2013 Jan 11;288(2):928-37

PMID:20194963 - Transformation/transcription domain-associated protein (TRRAP)-mediated regulation of Wee1.

Calonge TM et al. Genetics 2010 May;185(1):81-93

PMID:18753627 - Mcm4 C-terminal domain of MCM helicase prevents excessive formation of single-stranded DNA at stalled replication forks.

Nitani N et al. Proc Natl Acad Sci U S A 2008 Sep 02;105(35):12973-8

PMID:25822347 - Role of swi7H4 mutant allele of DNA polymerase α in the DNA damage checkpoint response.

Khan S et al. PLoS One 2015;10(3):e0124063

PMID:15550243 - Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage.

Sanders SL et al. Cell 2004 Nov 24;119(5):603-14

PMID:26201080 - The DNA-Binding Domain of S. pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers.

Zech J et al. PLoS One 2015;10(7):e0132595

PMID:15147268 - Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint.

Lehmann A et al. Genes Cells 2004 May;9(5):367-82

PMID:11715016 - Mrc1 transduces signals of DNA replication stress to activate Rad53.

Alcasabas AA et al. Nat Cell Biol 2001 Nov;3(11):958-65

PMID:22792081 - Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint.

Qu M et al. PLoS Genet 2012 Jul;8(7):e1002817

PMID:16252005 - Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase.

Liu C et al. EMBO J 2005 Nov 16;24(22):3940-51

PMID:33427950 - Checkpoint functions of RecQ helicases at perturbed DNA replication fork.

Ahamad N et al. Curr Genet 2021 Jun;67(3):369-382

PMID:9153313 - Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint.

Willson J et al. Nucleic Acids Res 1997 Jun 01;25(11):2138-46

PMID:8846774 - Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins.

Griffiths DJ et al. EMBO J 1995 Dec 01;14(23):5812-23

PMID:20679485 - BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint.

Sofueva S et al. Mol Cell Biol 2010 Oct;30(19):4732-43

PMID:10954610 - The stress-activated MAP kinase Sty1/Spc1 and a 3'-regulatory element mediate UV-induced expression of the uvi15(+) gene at the post-transcriptional level.

Kim M et al. Nucleic Acids Res 2000 Sep 01;28(17):3392-402

PMID:23584455 - Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage.

Dehé PM et al. Nat Struct Mol Biol 2013 May;20(5):598-603

PMID:22918952 - Multiple protein kinases influence the redistribution of fission yeast Clp1/Cdc14 phosphatase upon genotoxic stress.

Broadus MR et al. Mol Biol Cell 2012 Oct;23(20):4118-28

PMID:22095079 - The double-bromodomain proteins Bdf1 and Bdf2 modulate chromatin structure to regulate S-phase stress response in Schizosaccharomyces pombe.

Garabedian MV et al. Genetics 2012 Feb;190(2):487-500

PMID:23422000 - Regulatory motifs in Chk1.

Caparelli ML et al. Cell Cycle 2013 Mar 15;12(6):916-22

PMID:11359920 - Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast.

Takeda T et al. Mol Biol Cell 2001 May;12(5):1257-74

PMID:11523791 - A homologue of the Rad18 postreplication repair gene is required for DNA damage responses throughout the fission yeast cell cycle.

Verkade HM et al. Mol Genet Genomics 2001 Aug;265(6):993-1003

PMID:24861625 - Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.

Mahyous Saeyd SA et al. Nucleic Acids Res 2014 Jul;42(12):7734-47

PMID:35262697 - Replication stress induced by the ribonucleotide reductase inhibitor guanazole, triapine and gemcitabine in fission yeast.

Alyahya MY et al. FEMS Yeast Res 2022 Mar 24;22(1)

PMID:10430579 - Genetic control of telomere integrity in Schizosaccharomyces pombe: rad3(+) and tel1(+) are parts of two regulatory networks independent of the downstream protein kinases chk1(+) and cds1(+).

Matsuura A et al. Genetics 1999 Aug;152(4):1501-12

PMID:9572736 - Replication checkpoint enforced by kinases Cds1 and Chk1.

Boddy MN et al. Science 1998 May 08;280(5365):909-12

PMID:23211746 - Initiation of DNA damage responses through XPG-related nucleases.

Kuntz K et al. EMBO J 2013 Jan 23;32(2):290-302

PMID:37788281 - A dominant negative 14-3-3 mutant in Schizosaccharomyces pombe distinguishes the binding proteins involved in sexual differentiation and check point.

Ohshima T et al. PLoS One 2023;18(10):e0291524

PMID:26912660 - Gad8 Protein Is Found in the Nucleus Where It Interacts with the MluI Cell Cycle Box-binding Factor (MBF) Transcriptional Complex to Regulate the Response to DNA Replication Stress.

Cohen A et al. J Biol Chem 2016 Apr 22;291(17):9371-81

PMID:34228709 - Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.

Soriano I et al. PLoS Genet 2021 Jul;17(7):e1009526

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

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