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protein coding gene - ubc11 (SPCC1259.15c) - ubiquitin conjugating enzyme E2, for APC Ubc11/UbcP4

Gene summary

Standard name
ubc11
Systematic ID
SPCC1259.15c
Product
ubiquitin conjugating enzyme E2, for APC Ubc11/UbcP4
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
ubcdp, ubcP4
UniProt ID
O00103
ORFeome ID
43/43D10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1058486..1059788 reverse strand

Annotation

PBO:0000272 - 6.3.2.19

GO biological process

GO:0031145 - anaphase-promoting complex-dependent catabolic process

References:

GO:1902426 - deactivation of mitotic spindle assembly checkpoint

References:

GO:0045842 - positive regulation of mitotic metaphase/anaphase transition

References:

GO:0006511 - ubiquitin-dependent protein catabolic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0005515 - protein binding

References:

GO:0061631 - ubiquitin conjugating enzyme activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Multi-locus phenotype

FYPO:0003593 - abolished anaphase-promoting complex-dependent protein catabolic process

References:

Genotypes:

FYPO:0001327 - increased protein level during vegetative growth

References:

Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0002085 - normal vegetative cell growth

References:

Genotypes:

FYPO:0003503 - normal vegetative cell length

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000620 - abnormal cell cycle arrest in mitotic metaphase

References:

Genotypes:

FYPO:0000117 - abnormal septum assembly

References:

Genotypes:

FYPO:0003593 - abolished anaphase-promoting complex-dependent protein catabolic process

References:

Genotypes:

FYPO:0001913 - abolished ubiquitin ligase activity

References:

Genotypes:

FYPO:0001055 - cut following normal mitotic chromosome condensation

References:

Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0003585 - decreased anaphase-promoting complex-dependent protein catabolic process

References:

Genotypes:

FYPO:0004198 - decreased protein degradation during mitosis

References:

Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

References:

Genotypes:

FYPO:0002768 - decreased protein ubiquitination during vegetative growth

References:

Genotypes:

FYPO:0004085 - decreased vegetative cell growth

References:

Genotypes:

FYPO:0003592 - increased anaphase-promoting complex binding

References:

Genotypes:

FYPO:0001327 - increased protein level during vegetative growth

References:

Genotypes:

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0003875 - inviable elongated cell with mitotic G2/M transition delay and cell cycle arrest in M phase

References:

Genotypes:

FYPO:0004922 - inviable elongated mononucleate aseptate cell with cell cycle arrest at mitotic G2/M phase transition

References:

Genotypes:

FYPO:0002303 - inviable mononucleate monoseptate vegetative cell with anucleate compartment

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000324 - mitotic metaphase/anaphase transition delay

References:

Genotypes:

FYPO:0007652 - mononucleate vegetative cell with mislocalized septum and anucleate compartment

References:

Genotypes:

FYPO:0003594 - normal anaphase-promoting complex-dependent protein catabolic process

References:

Genotypes:

FYPO:0003570 - normal attachment of spindle microtubules to kinetochore

References:

Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00179UQ_conUBCPfam
cd23791UBCc_UBE2CCDD
PS00183UBC_1UBQ-conjugating_ASPROSITE patterns
PS50127UBC_2UBCPROSITE profiles
SM00212UBCcSMART
G3DSA:3.10.110.10:FF:000068CATH-FunFam
G3DSA:3.10.110.10UBQ-conjugating_enzyme/RWDCATH-Gene3D
SSF54495UBQ-conjugating_enzyme/RWDSUPERFAMILY
PTHR24067Ub_conjugating_enzyme-E2-likePANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:28947618 - Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.
Thakran P et al. EMBO J 2018 Jan 04;37(1):89-101
PMID:23416107 - Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer.
Olsen SK et al. Mol Cell 2013 Mar 07;49(5):884-96
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:28162934 - S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity.
Lv Z et al. Mol Cell 2017 Feb 16;65(4):699-714.e6
PMID:9154838 - A ubiquitin-conjugating enzyme in fission yeast that is essential for the onset of anaphase in mitosis.
Osaka F et al. Mol Cell Biol 1997 Jun;17(6):3388-97
PMID:23442800 - An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast.
Horikoshi Y et al. Cell Cycle 2013 Mar 15;12(6):961-71
PMID:35075549 - Schizosaccharomyces pombe Fzo1 is subjected to the ubiquitin-proteasome-mediated degradation during the stationary phase.
Ahmad F et al. Int Microbiol 2022 May;25(2):397-404
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26882497 - Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests.
Zich J et al. PLoS Genet 2016 Feb;12(2):e1005834
PMID:21389117 - Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast.
Kimata Y et al. Mol Biol Cell 2011 May;22(9):1486-94
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:12724408 - Two ubiquitin-conjugating enzymes, UbcP1/Ubc4 and UbcP4/Ubc11, have distinct functions for ubiquitination of mitotic cyclin.
Seino H et al. Mol Cell Biol 2003 May;23(10):3497-505
PMID:11279037 - Two WD repeat-containing TATA-binding protein-associated factors in fission yeast that suppress defects in the anaphase-promoting complex.
Mitsuzawa H et al. J Biol Chem 2001 May 18;276(20):17117-24
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:40982005 - E2 ubiquitin-conjugating enzyme Ubc11 regulates Rst2 protein stability in the fission yeast Schizosaccharomyces pombe.
Huang Y et al. Arch Microbiol 2025 Sep 22;207(11):275