PomBase - protein coding gene - spf30 (SPCC1281.02c) - splicing factor Spf30 - The Schizosaccharomyces pombe genome database

Protein features

ID	Name	InterPro name	DB name
PF18115	Tudor_3	Crb2_Tudor	PFAM
cd20446	Tudor_SpSPF30-like		CDD
SM00333	TUDOR_7	Tudor	SMART
SSF63748	Tudor/PWWP/MBT		SUPERFAMILY
G3DSA:2.30.30.140			GENE3D
PTHR46297	ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN		PANTHER
Coil	Coil		COILS
mobidb-lite-Disorder	disorder_prediction		MOBIDB-Disorder
mobidb-lite-Polar	disorder_prediction		MOBIDB-Polar
mobidb-lite-Polyampholyte	disorder_prediction		MOBIDB-Polyampholyte

References / Literature

PMID:28446597 - The histone variant H2A.Z promotes splicing of weak introns.: Nissen KE et al. Genes Dev 2017 Apr 01;31(7):688-701
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PB_REF:0000003 - Disease Association Curation
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.: Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.: Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.: Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.: Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.: Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.: Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:15755920 - Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex.: Carnahan RH et al. Eukaryot Cell 2005 Mar;4(3):577-87
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:21386897 - Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.: Ren L et al. PLoS One 2011 Feb 28;6(2):e16719
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.: Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20028739 - Splicing factor Spf30 assists exosome-mediated gene silencing in fission yeast.: Bernard P et al. Mol Cell Biol 2010 Mar;30(5):1145-57

protein coding gene - spf30 (SPCC1281.02c) - splicing factor Spf30

Gene summary

Annotation

Disease association

MONDO:0020128 - motor neuron disorder

MONDO:0005071 - nervous system disorder

GO biological process

GO:0000244 - spliceosomal tri-snRNP complex assembly

GO cellular component

GO:0005634 - nucleus

GO molecular function

GO:0003723 - RNA binding

Modification

MOD:00046 - O-phospho-L-serine

MOD:00047 - O-phospho-L-threonine

MOD:00048 - O4'-phospho-L-tyrosine

MOD:00696 - phosphorylated residue

MOD:01148 - ubiquitinylated lysine

Protein features

PBO:0111838 - tudor domain

Quantitative gene expression

PBO:0006310 - protein level

PBO:0011963 - RNA level

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

FYPO:0002279 - inviable after spore germination, single cell division, with elongated, curved germ tube

FYPO:0002212 - inviable after spore germination, without cell division, with elongated, curved germ tube

FYPO:0002061 - inviable vegetative cell population

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Protein features

Orthologs

References / Literature