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protein coding gene - rpl2302 (SPCC1322.11) - 60S ribosomal protein L23

Gene summary

Standard name
rpl2302
Systematic ID
SPCC1322.11
Product
60S ribosomal protein L23
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
rpl23-2
UniProt ID
P0CT61
ORFeome ID
41/41E03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1311622..1312384 forward strand

Annotation

GO biological process

GO:0002181 - cytoplasmic translation

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GO cellular component

GO:0022625 - cytosolic large ribosomal subunit

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GO:0005634 - nucleus

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GO molecular function

GO:0070180 - large ribosomal subunit rRNA binding

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GO:0003735 - structural constituent of ribosome

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Modification

MOD:00663 - methylated lysine

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000027 - ribosomal density decreased

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PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

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Genotypes:

FYPO:0003529 - inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001236 - normal growth on cycloheximide

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Genotypes:

FYPO:0007559 - normal growth on diethylstilbestrol

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Genotypes:

FYPO:0007558 - normal growth on econazole

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Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

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Genotypes:

FYPO:0000979 - normal growth on miconazole

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Genotypes:

FYPO:0002343 - normal growth on terbinafine

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Genotypes:

FYPO:0007557 - normal growth on tolnaftate

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00238Ribosomal_L14Ribosomal_uL14Pfam
cd00337Ribosomal_uL14CDD
PS00049RIBOSOMAL_L14Ribosomal_uL14_CSPROSITE patterns
SM01374Ribosomal_L14Ribosomal_uL14SMART
G3DSA:2.40.150.20:FF:000003CATH-FunFam
G3DSA:2.40.150.20Ribosomal_uL14_sfCATH-Gene3D
SSF50193Ribosomal_uL14_sfSUPERFAMILY
PTHR11761Ribosomal_uL14PANTHER
MF_01367Ribosomal_uL14Ribosomal_uL14HAMAP

Orthologs

References / Literature

PMID:39379376 - Ribosomes hibernate on mitochondria during cellular stress.
Gemin O et al. Nat Commun 2024 Oct 08;15(1):8666
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:20403971 - Proteomic and functional analysis of the noncanonical poly(A) polymerase Cid14.
Keller C et al. RNA 2010 Jun;16(6):1124-9
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:38051102 - Fission Yeast TORC1 Promotes Cell Proliferation through Sfp1, a Transcription Factor Involved in Ribosome Biogenesis.
Tai YT et al. Mol Cell Biol 2023 Dec 05;:1-18
PMID:34738170 - Overexpression of cell-wall GPI-anchored proteins restores cell growth of N-glycosylation-defective och1 mutants in Schizosaccharomyces pombe.
Fukunaga T et al. Appl Microbiol Biotechnol 2021 Dec;105(23):8771-8781
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:18292091 - Global analysis of gel mobility of proteins and its use in target identification.
Shirai A et al. J Biol Chem 2008 Apr 18;283(16):10745-52
PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.
Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183
PMID:42129552 - SNOR promotes translation restart after dormancy.
Gluc M et al. Nature 2026 May 13;
PMID:33223513 - Systematic Target Screening Revealed That Tif302 Could Be an Off-Target of the Antifungal Terbinafine in Fission Yeast.
Lee S et al. Biomol Ther (Seoul) 2021 Mar 01;29(2):234-247
PMID:26152728 - A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.
Mathiassen SG et al. J Biol Chem 2015 Aug 21;290(34):21141-21153