protein coding gene - ade6 (SPCC1322.13) - phosphoribosylaminoimidazole carboxylase Ade6

Gene summary

Standard name

ade6

Systematic ID

SPCC1322.13

Product

phosphoribosylaminoimidazole carboxylase Ade6

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

min1

UniProt ID

P15567

ORFeome ID

34/34G10

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 1316281..1318035 forward strand

Annotation

Protein features

Orthologs

• PAICS (HGNC:8587) Homo sapiens
• ade6 (SJAG_01081) Schizosaccharomyces japonicus
• ADE2 (YOR128C) Saccharomyces cerevisiae

References / Literature

PMID:9017391 - apd1+, a gene required for red pigment formation in ade6 mutants of Schizosaccharomyces pombe, encodes an enzyme required for glutathione biosynthesis: a role for glutathione and a glutathione-conjugate pump.

Chaudhuri B et al. Genetics 1997 Jan;145(1):75-83

PMID:29632066 - TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres.

Cohen A et al. J Biol Chem 2018 May 25;293(21):8138-8150

GO_REF:0000002 - Comments

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:29784772 - A Heterochromatin Domain Forms Gradually at a New Telomere and Is Dynamic at Stable Telomeres.

Wang J et al. Mol Cell Biol 2018 Aug 01;38(15)

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:1394510 - Regulation of pho1-encoded acid phosphatase of Schizosaccharomyces pombe by adenine and phosphate.

Schweingruber ME et al. Curr Genet 1992 Oct;22(4):289-92

PMID:499806 - Allelism of methionine-sensitive mutants of Schizosaccharomyces pombe to loci involved in adenine biosynthesis.

Strauss A Genet Res 1979 Jun;33(3):261-8

PMID:17261596 - Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.

Matsuo T et al. Mol Cell Biol 2007 Apr;27(8):3154-64

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:7855597 - A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction.

Szankasi P et al. Science 1995 Feb 24;267(5201):1166-9

PMID:25352017 - Implementation of the CRISPR-Cas9 system in fission yeast.

Jacobs JZ et al. Nat Commun 2014 Oct 29;5:5344

PMID:39527204 - Targeted Forward Genetics: Saturating Mutational Analyses of Specific Target Loci Within the Genome.

Protacio RU et al. Methods Mol Biol 2025;2862:223-239

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:2806887 - Meiotic recombination-deficient mutants of Schizosaccharomyces pombe.

Ponticelli AS et al. Genetics 1989 Sep;123(1):45-54

PMID:11104907 - Characterization of RAD52 homologs in the fission yeast Schizosaccharomyces pombe.

van den Bosch M et al. Mutat Res 2001 Jan 05;461(4):311-23

PMID:32295063 - The Catalytic-Dependent and -Independent Roles of Lsd1 and Lsd2 Lysine Demethylases in Heterochromatin Formation in Schizosaccharomyces pombe .

Marayati BF et al. Cells 2020 Apr 13;9(4)

PMID:8005432 - Transient, meiosis-induced expression of the rec6 and rec12 genes of Schizosaccharomyces pombe.

Lin Y et al. Genetics 1994 Mar;136(3):769-79

PMID:7565608 - Schizosaccharomyces pombe rds1, an adenine-repressible gene regulated by glucose, ammonium, phosphate, carbon dioxide and temperature.

Ludin KM et al. Mol Gen Genet 1995 Aug 30;248(4):439-45

PMID:8299939 - Region-specific activators of meiotic recombination in Schizosaccharomyces pombe.

DeVeaux LC et al. Genes Dev 1994 Jan;8(2):203-10

PMID:9076725 - Region-specific meiotic recombination in Schizosaccharomyces pombe: the rec11 gene.

Li YF et al. Mol Microbiol 1997 Mar;23(5):869-78

PMID:9671035 - Global control of meiotic recombination genes by Schizosaccharomyces pombe rec16 (rep1).

Ding R et al. Mol Gen Genet 1998 Jun;258(6):663-70

PMID:28469148 - Functional organization of protein determinants of meiotic DNA break hotspots.

Ma L et al. Sci Rep 2017 May 03;7(1):1393

PMID:12136010 - Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe.

Matsumoto S et al. Genetics 2002 Jul;161(3):1053-63

PMID:16115814 - Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe.

van Slegtenhorst M et al. Hum Mol Genet 2005 Oct 01;14(19):2851-8

PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78

PMID:25519804 - Nonsense codon suppression in fission yeast due to mutations of tRNA(Ser.11) and translation release factor Sup35 (eRF3).

Protacio RU et al. Curr Genet 2015 May;61(2):165-73

PMID:27613427 - Stress sensitivity of a fission yeast strain lacking histidine kinases is rescued by the ectopic expression of Chk1 from Candida albicans.

Maksimov V et al. Curr Genet 2017 May;63(2):343-357

PMID:1448066 - Purine biosynthetic genes are required for cadmium tolerance in Schizosaccharomyces pombe.

Speiser DM et al. Mol Cell Biol 1992 Dec;12(12):5301-10

PMID:14718525 - Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe.

van Slegtenhorst M et al. J Biol Chem 2004 Mar 26;279(13):12706-13

PMID:31712578 - DNA sequence differences are determinants of meiotic recombination outcome.

Brown SD et al. Sci Rep 2019 Nov 11;9(1):16446

PMID:3221399 - DNA sequence analysis of the ade6 gene of Schizosaccharomyces pombe. Wild-type and mutant alleles including the recombination host spot allele ade6-M26.

Szankasi P et al. J Mol Biol 1988 Dec 20;204(4):917-25

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:15292231 - Regulation of Swi6/HP1-dependent heterochromatin assembly by cooperation of components of the mitogen-activated protein kinase pathway and a histone deacetylase Clr6.

Kim HS et al. J Biol Chem 2004 Oct 08;279(41):42850-9

PMID:19436749 - Phosphorylation-independent regulation of Atf1-promoted meiotic recombination by stress-activated, p38 kinase Spc1 of fission yeast.

Gao J et al. PLoS One 2009;4(5):e5533

PMID:23145069 - Identification and functional analysis of the erh1(+) gene encoding enhancer of rudimentary homolog from the fission yeast Schizosaccharomyces pombe.

Krzyzanowski MK et al. PLoS One 2012;7(11):e49059

PMID:2743431 - An abnormal cell division cycle in an AIR carboxylase-deficient mutant of the fission yeast Schizosaccharomyces pombe.

Ishiguro J Curr Genet 1989 Jan;15(1):71-4

PMID:18257391 - Mouse and human La proteins differ in kinase substrate activity and activation mechanism for tRNA processing.

Park JM et al. Gene Expr 2007;14(2):71-81

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:7262540 - Regulatory genes controlling mitosis in the fission yeast Schizosaccharomyces pombe.

Nurse P et al. Genetics 1980 Nov;96(3):627-37

PMID:30640914 - CDK contribution to DSB formation and recombination in fission yeast meiosis.

Bustamante-Jaramillo LF et al. PLoS Genet 2019 Jan;15(1):e1007876

PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.

Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:17248775 - Genetic Mapping in SCHIZOSACCHAROMYCES POMBE by Mitotic and Meiotic Analysis and Induced Haploidization.

Kohli J et al. Genetics 1977 Nov;87(3):471-89

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:8625425 - pH sensitivity of Schizosaccharomyces pombe: effect on the cellular phenotype associated with lacZ gene expression.

Arndt GM et al. Curr Genet 1996 Apr;29(5):457-61

PMID:26152728 - A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.

Mathiassen SG et al. J Biol Chem 2015 Aug 21;290(34):21141-21153

PMID:22992726 - The SAGA histone acetyltransferase complex regulates leucine uptake through the Agp3 permease in fission yeast.

Takahashi H et al. J Biol Chem 2012 Nov 02;287(45):38158-67