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protein coding gene - ten1 (SPCC1393.14) - telomere cap complex subunit Ten1

Gene summary

Standard name
ten1
Systematic ID
SPCC1393.14
Product
telomere cap complex subunit Ten1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P0C5Y7
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 819849..820218 reverse strand

Annotation

GO biological process

GO:0016233 - telomere capping

References:

GO cellular component

GO:0140445 - chromosome, telomeric repeat region

References:

GO:1990879 - CST complex

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GO:0000782 - telomere cap complex

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GO molecular function

GO:0005515 - protein binding

References:

GO:0043047 - single-stranded telomeric DNA binding

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Protein features

PBO:0111871 - OB fold

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002702 - circularized chromosome

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Genotypes:

FYPO:0002262 - inviable after spore germination, multiple cell divisions, elongated cell

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Genotypes:

FYPO:0003742 - inviable after spore germination, multiple cell divisions, unequal chromosome segregation

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0001491 - viable vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF12658Ten1Ten1_fungalPFAM
G3DSA:2.40.50.140NA-bd_OB-foldGENE3D

Orthologs

References / Literature

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:19884503 - Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain.
Gelinas AD et al. Proc Natl Acad Sci U S A 2009 Nov 17;106(46):19298-303
PMID:24925530 - Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association.
Garg M et al. EMBO Rep 2014 Aug;15(8):871-7
PMID:17715303 - Protection of telomeres by a conserved Stn1-Ten1 complex.
Martín V et al. Proc Natl Acad Sci U S A 2007 Aug 28;104(35):14038-43
PMID:29774234 - The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.
Matmati S et al. Sci Adv 2018 May;4(5):eaar2740
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:30796050 - Ssu72 phosphatase is a conserved telomere replication terminator.
Escandell JM et al. EMBO J 2019 Apr 01;38(7)
PMID:20008938 - Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Sun J et al. Genes Dev 2009 Dec 15;23(24):2900-14
GO_REF:0000002 - Comments
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20519959 - S. pombe genome deletion project: an update.
Spirek M et al. Cell Cycle 2010 Jun 15;9(12):2399-402
PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.
Chen JS et al. Yeast 2016 Sep;33(9):507-17