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protein coding gene - SPCC13B11.03c - hydroxyacylglutathione hydrolase

Gene summary

Systematic ID
SPCC13B11.03c
Product
hydroxyacylglutathione hydrolase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94250
ORFeome ID
15/15C05
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 1594872..1596061 reverse strand

Annotation

PBO:0001127 - 3.1.2.6

Disease association

MONDO:0013535 - hydroxyacyl glutathione hydrolase deficiency

References:

MONDO:0000903 - myoclonus-dystonia syndrome

References:

GO biological process

GO:0051596 - methylglyoxal catabolic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0004416 - hydroxyacylglutathione hydrolase activity

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000636 - increased cell population growth rate

References:

Genotypes:

FYPO:0000763 - resistance to cadmium

References:

Genotypes:

FYPO:0002693 - resistance to diamide

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0001453 - resistance to ethanol

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF16123HAGH_CHAGH_CPFAM
PF00753Lactamase_BMetallo-B-lactamasPFAM
cd07723hydroxyacylglutathione_hydrolase_MBL-foldClx_II_MBLCDD
SM00849Lactamase_B_5aMetallo-B-lactamasSMART
G3DSA:3.60.15.10:FF:000045FUNFAM
SSF56281Metallo-hydrolase/oxidoreductaseRibonucZ/Hydroxyglut_hydroSUPERFAMILY
G3DSA:3.60.15.10RibonucZ/Hydroxyglut_hydroGENE3D
PTHR11935BETA LACTAMASE DOMAINPANTHER
MF_01374Glyoxalase_2Hydroxyacylglutathione_HdrlaseHAMAP
TIGR03413GSH_gloBHydroxyacylglutathione_HdrlaseNCBIFAM

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PB_REF:0000003 - Disease Association Curation
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55