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protein coding gene - fmd3 (SPCC13B11.04c) - glutathione-dependent formaldehyde dehydrogenase

Gene summary

Standard name
fmd3
Systematic ID
SPCC13B11.04c
Product
glutathione-dependent formaldehyde dehydrogenase
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPCC777.01c
UniProt ID
O74540
ORFeome ID
18/18G06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1596549..1599018 reverse strand

Annotation

PBO:0004930 - 1.1.1.284

Disease association

MONDO:0007079 - alcohol dependence

References:

MONDO:0030894 - AMED syndrome, digenic

References:

GO biological process

GO:0046294 - formaldehyde catabolic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005739 - mitochondrion

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0004022 - alcohol dehydrogenase (NAD+) activity

References:

GO:0033833 - hydroxymethylfurfural reductase (NADH) activity

References:

GO:0106322 - S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity

References:

GO:0106321 - S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity

References:

GO:0080007 - S-nitrosoglutathione reductase (NADH) activity

References:

GO:0008270 - zinc ion binding

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0000250 - decreased cell population growth on proline nitrogen source

References:

Genotypes:

FYPO:0005776 - normal growth on acetaldehyde

References:

Genotypes:

FYPO:0007331 - normal growth on formaldehyde

References:

Genotypes:

FYPO:0001453 - resistance to ethanol

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF08240ADH_NADH-like_NPFAM
PF00107ADH_zinc_NADH-like_CPFAM
cd08300alcohol_DH_class_IIIADH_3CDD
PS00059ADH_ZINCADH_Zn_CSPROSITE_PATTERNS
G3DSA:3.40.50.720:FF:000003FUNFAM
G3DSA:3.90.180.10:FF:000001FUNFAM
SSF50129GroES-likeGroES-like_sfSUPERFAMILY
SSF51735NAD(P)-binding Rossmann-fold domainsNAD(P)-bd_dom_sfSUPERFAMILY
G3DSA:3.90.180.10GENE3D
G3DSA:3.40.50.720GENE3D
PTHR43880ALCOHOL DEHYDROGENASEPANTHER
TIGR02818adh_III_F_hydeADH_3NCBIFAM

Orthologs

References / Literature

PMID:29214404 - The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast.
Seo HD et al. Curr Genet 2018 Jun;64(3):741-752
PMID:26645666 - Nitric oxide signaling and its role in oxidative stress response in Schizosaccharomyces pombe.
Astuti RI et al. Nitric Oxide 2016 Jan 30;52:29-40
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.
Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:32034465 - Genetic investigation of formaldehyde-induced DNA damage response in Schizosaccharomyces pombe.
Anandarajan V et al. Curr Genet 2020 Jun;66(3):593-605
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12