protein coding gene - ste6 (SPCC1442.01) - RasGEF Ste6

Gene summary

Standard name

ste6

Systematic ID

SPCC1442.01

Product

RasGEF Ste6

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

SPCC1450.17

UniProt ID

P26674

ORFeome ID

39/39A11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 1766086..1768971 forward strand

Annotation

Protein features

Orthologs

• RAPGEF1 (HGNC:4568) Homo sapiens
• RASGRF1 (HGNC:9875) Homo sapiens
• RASGRF2 (HGNC:9876) Homo sapiens
• ste6 (SJAG_02486) Schizosaccharomyces japonicus
• CDC25 (YLR310C) Saccharomyces cerevisiae

References / Literature

PMID:12052869 - Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factors.

Papadaki P et al. Mol Cell Biol 2002 Jul;22(13):4598-606

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:1883874 - sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1.

Wang Y et al. Cell Regul 1991 Jun;2(6):453-65

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:12898217 - MCB-mediated regulation of cell cycle-specific cdc22+ transcription in fission yeast.

Maqbool Z et al. Mol Genet Genomics 2003 Sep;269(6):765-75

PMID:3185514 - The role of sterility genes (ste and aff) in the initiation of sexual development in Schizosaccharomyces pombe.

Sipiczki M Mol Gen Genet 1988 Aug;213(2-3):529-34

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:2038319 - Identification of a GTPase-activating protein homolog in Schizosaccharomyces pombe.

Imai Y et al. Mol Cell Biol 1991 Jun;11(6):3088-94

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:2107403 - Homologous activators of ras in fission and budding yeast.

Hughes DA et al. Nature 1990 Mar 22;344(6264):355-7

PMID:24167631 - Klf1, a C2H2 zinc finger-transcription factor, is required for cell wall maintenance during long-term quiescence in differentiated G0 phase.

Shimanuki M et al. PLoS One 2013;8(10):e78545

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

Sun LL et al. PLoS Genet 2013;9(8):e1003715

PMID:41844616 - Phosphoregulation of the novel hemi-arrestin MAPK scaffold Sms1 prevents untimely mating.

Sieber B et al. Nat Commun 2026 Mar 17;

PMID:9133664 - The Schizosaccharomyces pombe mra1 gene, which is required for cell growth and mating, can suppress the mating inefficiency caused by a deficit in the Ras1 activity.

Hakuno F et al. Genes Cells 1996 Mar;1(3):303-15

PMID:7975894 - Mating pheromone-induced expression of the mat1-Pm gene of Schizosaccharomyces pombe: identification of signalling components and characterization of upstream controlling elements.

Aono T et al. Yeast 1994 Jun;10(6):757-70

PMID:14648198 - DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.

Cunliffe L et al. Mol Genet Genomics 2004 Feb;271(1):60-71

PMID:29453312 - Inhibition of Ras activity coordinates cell fusion with cell-cell contact during yeast mating.

Merlini L et al. J Cell Biol 2018 Apr 02;217(4):1467-1483

PMID:8264618 - Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe.

Xu HP et al. Mol Cell Biol 1994 Jan;14(1):50-8

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.

Materne P et al. Elife 2015 Jun 22;4:e09008

PMID:1934121 - Pheromone production and response in sterile mutants of fission yeast.

Leupold U et al. Curr Genet 1991 Jul;20(1-2):79-85

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:31276588 - Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3' processing and transcription termination.

Sanchez AM et al. Nucleic Acids Res 2019 Sep 19;47(16):8452-8469

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:19714215 - The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.

Aligianni S et al. PLoS Genet 2009 Aug;5(8):e1000626

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399