protein coding gene - pre8 (SPCC1442.06) - 20S proteasome complex subunit alpha 2, Pre8

Gene summary

Standard name

pre8

Systematic ID

SPCC1442.06

Product

20S proteasome complex subunit alpha 2, Pre8

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O94579

ORFeome ID

15/15G06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 1778094..1780442 forward strand

Annotation

Protein features

Orthologs

• PSMA2 (HGNC:9531) Homo sapiens
• pre8 (SJAG_02502) Schizosaccharomyces japonicus
• PRE8 (YML092C) Saccharomyces cerevisiae

References / Literature

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:20133687 - Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.

Takeda K et al. Proc Natl Acad Sci U S A 2010 Feb 23;107(8):3540-5

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:20838651 - A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.

Kouranti I et al. PLoS Biol 2010 Sep 07;8(9)

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:28784663 - The 19S proteasome is directly involved in the regulation of heterochromatin spreading in fission yeast.

Seo HD et al. J Biol Chem 2017 Oct 13;292(41):17144-17155

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:21098295 - Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution.

Bohn S et al. Proc Natl Acad Sci U S A 2010 Dec 07;107(49):20992-7

PMID:22307589 - Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.

Lasker K et al. Proc Natl Acad Sci U S A 2012 Jan 31;109(5):1380-7

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:24938783 - Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes.

Leitner A et al. Proc Natl Acad Sci U S A 2014 Jul 01;111(26):9455-60

PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.

Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663

PMID:22187461 - The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together.

Pathare GR et al. Proc Natl Acad Sci U S A 2012 Jan 03;109(1):149-54