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protein coding gene - wss2 (SPCC1442.07c) - ubiquitin/metalloprotease fusion protein Udp7

Gene summary

Standard name
wss2
Systematic ID
SPCC1442.07c
Product
ubiquitin/metalloprotease fusion protein Udp7
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
udp7
UniProt ID
O94580
ORFeome ID
11/11B05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1779522..1780601 reverse strand

Annotation

Comment

PBO:0010216 - related to S. pombe SPAC521.02 and S. cerevisiae YHR134W, but has an additional N-terminal ubiquitin family domain

GO biological process

GO:0006281 - DNA repair

References:

GO:0016925 - protein sumoylation

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

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GO molecular function

GO:0003690 - double-stranded DNA binding

References:

GO:0008237 - metallopeptidase activity

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GO:0070628 - proteasome binding

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GO:0003697 - single-stranded DNA binding

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GO:0046914 - transition metal ion binding

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Genome organisation

PBO:0000229 - tandem fusion protein

Modification

MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0000972 - increased number of Rad52 foci during vegetative growth

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Genotypes:

FYPO:0001690 - normal growth on camptothecin

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Genotypes:

FYPO:0005775 - sensitive to acetaldehyde

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Genotypes:

FYPO:0000085 - sensitive to camptothecin

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Genotypes:

FYPO:0007330 - sensitive to formaldehyde

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Genotypes:

Protein features

PBO:0111862 - ubiquitin family protein

Qualitative gene expression

PomGeneEx:0000026 - ribosomal density increased

References:

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000659 - abolished DNA binding

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Genotypes:

FYPO:0000972 - increased number of Rad52 foci during vegetative growth

References:

Genotypes:

FYPO:0001690 - normal growth on camptothecin

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Genotypes:

FYPO:0001023 - normal growth on cisplatin

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Genotypes:

FYPO:0007331 - normal growth on formaldehyde

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0006680 - sensitive to bisphenol A

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0007330 - sensitive to formaldehyde

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Protein features

IDNameInterPro nameDB name
PF00240ubiquitinUbiquitin-like_domPFAM
PF08325WLMWLM_domPFAM
PS51397WLMWLM_domPROSITE_PROFILES
PS50053UBIQUITIN_2Ubiquitin-like_domPROSITE_PROFILES
SM00213ubq_7Ubiquitin-like_domSMART
SSF54236Ubiquitin-likeUbiquitin-like_domsfSUPERFAMILY
G3DSA:3.10.20.90GENE3D
PTHR47795UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07CPANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Polyampholytedisorder_predictionMOBIDB-Polyampholyte

Orthologs

References / Literature

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.
Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:12615927 - Interaction of the anaphase-promoting complex/cyclosome and proteasome protein complexes with multiubiquitin chain-binding proteins.
Seeger M et al. J Biol Chem 2003 May 09;278(19):16791-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:27871365 - Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN.
Stingele J et al. Mol Cell 2016 Nov 17;64(4):688-703
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:28821619 - Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.
Burr R et al. J Biol Chem 2017 Sep 29;292(39):16333-16350
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:32034465 - Genetic investigation of formaldehyde-induced DNA damage response in Schizosaccharomyces pombe.
Anandarajan V et al. Curr Genet 2020 Jun;66(3):593-605
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:27687866 - Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast.
Noguchi C et al. Cell Cycle 2017 Jan 02;16(1):45-58
PMID:21247416 - Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.
Gatti L et al. BMC Genomics 2011 Jan 19;12:44