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protein coding gene - pps1 (SPCC1442.12) - CDP-diacylglycerol-serine O-phosphatidyltransferase Pps1

Gene summary

Standard name
pps1
Systematic ID
SPCC1442.12
Product
CDP-diacylglycerol-serine O-phosphatidyltransferase Pps1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94584
ORFeome ID
17/17F08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1789563..1791260 forward strand

Annotation

PBO:0005637 - 2.7.8.8

GO biological process

GO:0016024 - CDP-diacylglycerol biosynthetic process

References:

GO:0071277 - cellular response to calcium ion

References:

GO:0035865 - cellular response to potassium ion

References:

GO:0006646 - phosphatidylethanolamine biosynthetic process

References:

GO:0006659 - phosphatidylserine biosynthetic process

References:

GO:0006658 - phosphatidylserine metabolic process

References:

GO:0007009 - plasma membrane organization

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0005783 - endoplasmic reticulum

References:

GO:0005789 - endoplasmic reticulum membrane

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GO:0005886 - plasma membrane

References:

GO molecular function

GO:0003882 - CDP-diacylglycerol-serine O-phosphatidyltransferase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00696 - phosphorylated residue

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Multi-locus phenotype

FYPO:0003150 - decreased NETO

References:

Genotypes:

FYPO:0000098 - sensitive to calcium

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000190 - abnormal actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0000174 - abnormal cell wall biogenesis

References:

Genotypes:

FYPO:0004964 - actin cortical patches present in decreased numbers

References:

Genotypes:

FYPO:0000134 - branched, elongated, multiseptate cell

References:

Genotypes:

FYPO:0001292 - decreased CDP-diacylglycerol-serine O-phosphatidyltransferase activity

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Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0001285 - decreased cellular phosphatidylethanolamine level

References:

Genotypes:

FYPO:0006330 - decreased endoplasmic reticulum-plasma membrane tethering

References:

Genotypes:

FYPO:0003150 - decreased NETO

References:

Genotypes:

FYPO:0003771 - decreased protein localization to plasma membrane of cell tip during vegetative growth

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0002297 - dispersed actin cortical patch localization during mitotic interphase

References:

Genotypes:

FYPO:0007327 - DNA content decreased during G0

References:

Genotypes:

FYPO:0000038 - growth auxotrophic for ethanolamine

References:

Genotypes:

FYPO:0001286 - increased cellular phosphoinositide level

References:

Genotypes:

FYPO:0008330 - increased phosphatidylinositol-4-phosphate level in plasma membrane

References:

Genotypes:

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0001294 - normal actin cortical patch localization

References:

Genotypes:

FYPO:0001293 - normal cell wall biogenesis

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0002657 - normal occurrence of NETO

References:

Genotypes:

FYPO:0004963 - normal plasma membrane sterol distribution

References:

Genotypes:

FYPO:0008294 - normal plasma membrane-ER tethering

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Genotypes:

FYPO:0005168 - normal protein level during cellular response to salt stress

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Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0000644 - normal protein localization during vegetative growth

References:

Genotypes:

FYPO:0005890 - normal protein localization to nucleus during cellular response to calcium ion

References:

Genotypes:

FYPO:0001266 - normal protein phosphorylation during cellular response to salt stress

References:

Genotypes:

FYPO:0000776 - normal protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0001315 - normal vegetative cell morphology

References:

Genotypes:

FYPO:0001284 - phosphatidylserine absent from cell

References:

Genotypes:

FYPO:0008329 - phosphatidylserine absent from plasma membrane

References:

Genotypes:

FYPO:0000098 - sensitive to calcium

References:

Genotypes:

FYPO:0001188 - sensitive to Calcofluor White

References:

Genotypes:

FYPO:0001190 - sensitive to cell wall-degrading enzymes

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

FYPO:0000647 - vegetative cell lysis

References:

Genotypes:

FYPO:0003481 - viable elongated vegetative cell, elongated upon mitotic entry

References:

Genotypes:

FYPO:0002106 - viable stubby vegetative cell

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF01066CDP-OH_P_transfCDP-OH_P_transPfam
PS00379CDP_ALCOHOL_P_TRANSFCDP_ALCOHOL_P_TRANSF_CSPROSITE patterns
G3DSA:1.20.120.1760:FF:000022CATH-FunFam
G3DSA:1.20.120.1760CDP-OH_PTrfase_TM_domCATH-Gene3D
PTHR14269CDP-alcohol_PTase-IPANTHER
PIRSF000852Phosphatidylserine_synth_funCDP-diaglyc--ser_O-PTrfase_funPIRSF
TIGR00473pssACDP-diaglyc--ser_O-PTrfaseNCBIFAM
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:34706246 - Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns.
Hümmer S et al. Cell Rep 2021 Oct 26;37(4):109893
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:39110593 - VAP-mediated membrane-tethering mechanisms implicate ER-PM contact function in pH homeostasis.
Hoh KL et al. Cell Rep 2024 Aug 05;43(8):114592
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:17905925 - Functional characterization of the fission yeast phosphatidylserine synthase gene, pps1, reveals novel cellular functions for phosphatidylserine.
Matsuo Y et al. Eukaryot Cell 2007 Nov;6(11):2092-101
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:19366728 - Genetic control of cellular quiescence in S. pombe.
Sajiki K et al. J Cell Sci 2009 May 01;122(Pt 9):1418-29
PMID:27852900 - Gradients of phosphatidylserine contribute to plasma membrane charge localization and cell polarity in fission yeast.
Haupt A et al. Mol Biol Cell 2017 Jan 01;28(1):210-220
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:1324908 - Regulation of CDP-diacylglycerol synthesis and utilization by inositol and choline in Schizosaccharomyces pombe.
Gaynor PM et al. J Bacteriol 1992 Sep;174(17):5711-8
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20531409 - Global coordination of transcriptional control and mRNA decay during cellular differentiation.
Amorim MJ et al. Mol Syst Biol 2010 Jun 08;6:380
PMID:38598031 - Pps1, phosphatidylserine synthase, regulates the salt stress response in Schizosaccharomyces pombe.
Naozuka G et al. Mol Genet Genomics 2024 Apr 10;299(1):43
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101