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protein coding gene - grx3 (SPCC1450.06c) - CIA machinery monothiol glutaredoxin Grx3

Gene summary

Standard name
grx3
Systematic ID
SPCC1450.06c
Product
CIA machinery monothiol glutaredoxin Grx3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9Y7N3
ORFeome ID
04/04H09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1735279..1736106 reverse strand

Annotation

PBO:0005615 - 1.20.4.1

GO biological process

GO:0034599 - cellular response to oxidative stress

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GO cellular component

GO:0005801 - cis-Golgi network

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GO:0005783 - endoplasmic reticulum

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GO:0000324 - fungal-type vacuole

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GO:0005794 - Golgi apparatus

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GO:0005796 - Golgi lumen

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GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network

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GO:0034399 - nuclear periphery

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GO molecular function

GO:0015038 - glutathione disulfide oxidoreductase activity

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Protein features

PBO:0111760 - thioredoxin family

Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0002780 - decreased cellular reactive oxygen species level during vegetative growth

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Genotypes:

FYPO:0002143 - decreased cellular reactive oxygen species level in stationary phase

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Genotypes:

FYPO:0000470 - decreased mating type switching

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Genotypes:

FYPO:0000637 - increased cell population growth rate on glucose carbon source

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Genotypes:

FYPO:0003965 - increased glutathione disulfide oxidoreductase activity

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0001240 - normal growth on diamide

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Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

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Genotypes:

FYPO:0000962 - normal growth on hydrogen peroxide

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Genotypes:

FYPO:0001691 - normal growth on paraquat

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Genotypes:

FYPO:0001517 - resistance to aluminium

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001109 - resistance to menadione

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0002689 - sensitive to cumene hydroperoxide

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009084 - sensitive to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001214 - sensitive to potassium chloride

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000115 - sensitive to valproic acid

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

Protein features

IDNameInterPro nameDB name
PF00462GlutaredoxinGlutaredoxinPFAM
cd03419GRX_GRXh_1_2_likeCDD
PS51354GLUTAREDOXIN_2PROSITE_PROFILES
PR00160GLUTAREDOXINGlutaredoxin_subgrPRINTS
SSF52833Thioredoxin-likeThioredoxin-like_sfSUPERFAMILY
G3DSA:3.40.30.10GlutaredoxinGENE3D
PTHR45694GLUTAREDOXIN 2PANTHER
TIGR02180GRX_eukGlutaredoxin_euk/virNCBIFAM

Orthologs

References / Literature

PMID:16258244 - Characterization and regulation of the gene encoding monothiol glutaredoxin 3 in the fission yeast Schizosaccharomyces pombe.
Moon JS et al. Mol Cells 2005 Aug 31;20(1):74-82
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:18182845 - Expression, characterization and regulation of a Saccharomyces cerevisiae monothiol glutaredoxin (Grx6) gene in Schizosaccharomyces pombe.
Lee JH et al. Mol Cells 2007 Dec 31;24(3):316-22
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.
Maki T et al. PLoS Genet 2018 May;14(5):e1007424
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.
Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
PMID:15796926 - Localization and function of three monothiol glutaredoxins in Schizosaccharomyces pombe.
Chung WH et al. Biochem Biophys Res Commun 2005 May 06;330(2):604-10
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160