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protein coding gene - ero12 (SPCC1450.14c) - ER protein folding oxidoreductin Ero1b

Gene summary

Standard name
ero12
Systematic ID
SPCC1450.14c
Product
ER protein folding oxidoreductin Ero1b
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9Y7P1
ORFeome ID
36/36G03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1758944..1761093 reverse strand

Annotation

Complementation

PBO:0024873 - functionally complements S. cerevisiae ERO1

References:

GO biological process

GO:0034975 - protein folding in endoplasmic reticulum

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GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0005789 - endoplasmic reticulum membrane

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GO molecular function

GO:0071949 - FAD binding

References:

GO:0016971 - flavin-dependent sulfhydryl oxidase activity

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GO:0015035 - protein-disulfide reductase activity

References:

GO:0016972 - thiol oxidase activity

References:

Modification

MOD:00689 - disulfide crosslinked residues

References:

MOD:00693 - glycosylated residue

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MOD:00006 - N-glycosylated residue

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MOD:00046 - O-phospho-L-serine

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Protein sequence feature

SO:0000418 - signal_peptide

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0002240 - swollen septated spheroid vegetative cell

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF04137ERO1Ero1PFAM
SSF110019ERO1-likeERO1-like_sfSUPERFAMILY
PTHR12613ERO1-RELATEDEro1PANTHER
PIRSF017205EROEro1PIRSF

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:15449306 - Schizosaccharomyces pombe ER oxidoreductin-like proteins SpEro1a p and SpEro1b p.
Kettner K et al. Yeast 2004 Sep;21(12):1035-44
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000002 - Comments
GO_REF:0000033 - Annotation inferences using phylogenetic trees