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protein coding gene - SPCC1450.15 - pig-F/3-ketosphinganine reductase fusion protein

Gene summary

Systematic ID
SPCC1450.15
Product
pig-F/3-ketosphinganine reductase fusion protein
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9Y7P2
ORFeome ID
45/45B01
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 1761184..1763220 forward strand

Annotation

Disease association

MONDO:0033014 - erythrokeratodermia variabilis et progressiva 4

References:

MONDO:0859161 - onychodystrophy, osteodystrophy, impaired intellectual development, and seizures syndrome

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GO biological process

GO:0006666 - 3-keto-sphinganine metabolic process

References:

GO:0006506 - GPI anchor biosynthetic process

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GO:0030148 - sphingolipid biosynthetic process

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GO cellular component

GO:0005789 - endoplasmic reticulum membrane

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GO molecular function

GO:0047560 - 3-dehydrosphinganine reductase activity

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GO:0051377 - mannose-ethanolamine phosphotransferase activity

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GO:0070402 - NADPH binding

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Genome organisation

PBO:0000228 - domain combination not observed in other organisms

PBO:0000229 - tandem fusion protein

Modification

MOD:00046 - O-phospho-L-serine

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Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF06699PIG-FGPI_biosynthesis_protein_Pig-FPFAM
PF00106adh_shortSDR_famPFAM
cd08939KDSR-like_SDR_cKDSR-likeCDD
PR00081GDHRDHSDR_famPRINTS
SSF51735NAD(P)-binding Rossmann-fold domainsNAD(P)-bd_dom_sfSUPERFAMILY
G3DSA:3.40.50.720GENE3D
PTHR435503-KETODIHYDROSPHINGOSINE REDUCTASEPANTHER

Orthologs

References / Literature

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663