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protein coding gene - taf13 (SPCC1494.02c) - transcription factor TFIID complex subunit Taf13

Gene summary

Standard name
taf13
Systematic ID
SPCC1494.02c
Product
transcription factor TFIID complex subunit Taf13
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O60076
ORFeome ID
43/43F07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 2317999..2319040 reverse strand

Annotation

Disease association

MONDO:0044313 - intellectual disability, autosomal recessive 60

References:

GO biological process

GO:0051123 - RNA polymerase II preinitiation complex assembly

References:

GO:0006367 - transcription initiation at RNA polymerase II promoter

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0005669 - transcription factor TFIID complex

References:

GO molecular function

GO:0016251 - RNA polymerase II general transcription initiation factor activity

References:

Protein features

PBO:0111763 - histone fold

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02269TFIID-18kDaTFIID_TAF13PFAM
cd07978HFD_TAF13CDD
G3DSA:1.10.20.10:FF:000071FUNFAM
SSF47113Histone-foldHistone-foldSUPERFAMILY
G3DSA:1.10.20.10Histone, subunit AHistone-foldGENE3D
PTHR11380TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATEDTFIID_TAF13PANTHER

Orthologs

References / Literature

PMID:8303296 - RNA polymerase II initiation factor interactions and transcription start site selection.
Li Y et al. Science 1994 Feb 11;263(5148):805-7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:19913479 - Cryo-EM reveals promoter DNA binding and conformational flexibility of the general transcription factor TFIID.
Elmlund H et al. Structure 2009 Nov 11;17(11):1442-52
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:29079657 - TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.
Laboucarié T et al. EMBO Rep 2017 Dec;18(12):2197-2218
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6