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protein coding gene - tfb6 (SPCC1494.09c) - transcription factor TFIIH complex subunit Tfb6

Gene summary

Standard name
tfb6
Systematic ID
SPCC1494.09c
Product
transcription factor TFIIH complex subunit Tfb6
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O60083
ORFeome ID
05/05E04
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 2342622..2343898 reverse strand

Annotation

GO biological process

GO:0006367 - transcription initiation at RNA polymerase II promoter

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GO cellular component

GO:0005634 - nucleus

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GO:0005675 - transcription factor TFIIH holo complex

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0009052 - increased cell population growth on glutamate nitrogen source

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Genotypes:

FYPO:0009031 - resistance to bleomycin

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0001453 - resistance to ethanol

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FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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FYPO:0000830 - resistance to vanadate

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FYPO:0001501 - sensitive to brefeldin A

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FYPO:0007931 - sensitive to egtazic acid

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FYPO:0000785 - sensitive to formamide

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FYPO:0000087 - sensitive to hydrogen peroxide

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FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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FYPO:0003656 - sensitive to vanadate

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FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0091995 - Tfb6 annotation seems tenuous, SGD have not annotated

Protein features

IDNameInterPro nameDB name
PF17110TFB6Tfb6Pfam
PTHR37781Tfb6PANTHER

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.
Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12