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protein coding gene - ump1 (SPCC14G10.03c) - proteasome maturation factor Ump1

Gene summary

Standard name
ump1
Systematic ID
SPCC14G10.03c
Product
proteasome maturation factor Ump1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74416
ORFeome ID
04/04G05
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 747501..748582 reverse strand

Annotation

Disease association

MONDO:0011169 - keratosis linearis-ichthyosis congenita-sclerosing keratoderma syndrome

References:

MONDO:0054700 - proteasome-associated autoinflammatory syndrome 2

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GO biological process

GO:0080129 - proteasome core complex assembly

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GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

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GO molecular function

GO:0044183 - protein folding chaperone

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Modification

MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0006606 - abnormal dynamic protein localization pattern

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0006100 - decreased protein localization to cytoplasm, with protein mislocalized to nucleus

References:

Genotypes:

FYPO:0004056 - decreased protein localization to nucleus, with protein mislocalized to cytoplasm

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Genotypes:

FYPO:0000836 - increased protein level

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Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0006606 - abnormal dynamic protein localization pattern

References:

Genotypes:

FYPO:0000229 - cut

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Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0004545 - decreased proteasomal ubiquitin-dependent protein degradation

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Genotypes:

FYPO:0003865 - decreased protein level during G0

References:

Genotypes:

FYPO:0006100 - decreased protein localization to cytoplasm, with protein mislocalized to nucleus

References:

Genotypes:

FYPO:0004056 - decreased protein localization to nucleus, with protein mislocalized to cytoplasm

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0005382 - delayed exit from meiosis

References:

Genotypes:

FYPO:0004808 - increased cellular protein aggregate level during cellular response to heat

References:

Genotypes:

FYPO:0002774 - increased level of ubiquitinated protein in cell during vegetative growth

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Genotypes:

FYPO:0000836 - increased protein level

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Genotypes:

FYPO:0000099 - sensitive to canavanine

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Genotypes:

FYPO:0000021 - spheroid vegetative cell

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Genotypes:

FYPO:0002380 - viable spheroid vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF05348UMP1PFAM
PTHR12828PROTEASOME MATURATION PROTEIN UMP1Ump1PANTHER

Orthologs

References / Literature

PMID:25002536 - A novel histone deacetylase complex in the control of transcription and genome stability.
Zilio N et al. Mol Cell Biol 2014 Sep 15;34(18):3500-14
PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.
Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:20133687 - Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.
Takeda K et al. Proc Natl Acad Sci U S A 2010 Feb 23;107(8):3540-5
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:39473973 - Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity.
Ruiz-Romero G et al. iScience 2024 Nov 15;27(11):111095
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531