protein coding gene - coq3 (SPCC162.05) - decaprenyldihydroxybenzoate methyltransferase Coq3

Gene summary

Standard name: coq3
Systematic ID: SPCC162.05
Product: decaprenyldihydroxybenzoate methyltransferase Coq3
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O74421
ORFeome ID: 43/43D01
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome III: 1578091..1579074 reverse strand

Annotation

PBO:0005556 - 2.1.1.114

Complementation

PBO:0036533 - functionally complemented by A. thaliana COQ3

References:

PMID:24911838

PBO:0036532 - functionally complemented by human COQ3 with an S. pombe MTS

References:

PMID:24911838

GO biological process

GO:0006744 - ubiquinone biosynthetic process

References:

PMID:24911838

GO cellular component

GO:0031314 - extrinsic component of mitochondrial inner membrane

References:

GO_REF:0000111

GO:0005743 - mitochondrial inner membrane

References:

PMID:24911838

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0061542 - 3-demethylubiquinol 3-O-methyltransferase activity

References:

GO_REF:0000116

GO:0120537 - 3-demethylubiquinone 3-O-methyltransferase activity

References:

GO_REF:0000116

GO:0010420 - polyprenyldihydroxybenzoate methyltransferase activity

References:

GO_REF:0000033

Multi-locus phenotype

FYPO:0003374 - normal cellular coenzyme Q10 level

References:

PMID:25647499

Genotypes:

abc1+(wild type)[Overexpression] coq3+(wild type)[Overexpression] coq4+(wild type)[Overexpression] coq5+(wild type)[Overexpression] coq6+(wild type)[Overexpression] coq7+(wild type)[Overexpression] coq9+(wild type)[Overexpression] dlp1+(wild type)[Overexpression] dps1+(wild type)[Overexpression] ppt1+(wild type)[Overexpression]

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

PMID:36408920

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000078 - abnormal cellular respiration

References:

PMID:18808426

Genotypes:

coq3delta

FYPO:0001934 - abolished cell population growth on glycerol carbon source

References:

PMID:18665268

Genotypes:

coq3delta

FYPO:0003690 - abolished cell population growth on glycerol/ethanol carbon source

References:

PMID:24911838

Genotypes:

coq3delta

FYPO:0001712 - coenzyme Q10 absent from cell

References:

PMID:24911838

Genotypes:

coq3delta

FYPO:0000708 - decreased mating efficiency

References:

PMID:23950735

Genotypes:

coq3delta

FYPO:0002009 - decreased oxygen consumption during vegetative growth

References:

PMID:18808426

Genotypes:

coq3delta

FYPO:0001355 - decreased vegetative cell population growth

References:

PMID:18665268

Genotypes:

coq3delta

FYPO:0008128 - decreased vegetative cell population growth on low glucose

References:

PMID:37859837

Genotypes:

coq3delta

FYPO:0000246 - growth auxotrophic for antioxidant

References:

PMID:24911838

Genotypes:

coq3delta

FYPO:0002723 - increased cellular pigment accumulation during cellular response to cadmium ion

References:

PMID:18684775

Genotypes:

coq3delta

FYPO:0001413 - increased cellular sulfide level

References:

PMID:18808426

Genotypes:

coq3delta

FYPO:0003692 - increased protein phosphorylation during cellular response to oxidative stress

References:

PMID:18808426

Genotypes:

coq3delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

coq3delta

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

coq3delta

FYPO:0003374 - normal cellular coenzyme Q10 level

References:

PMID:25647499

Genotypes:

coq3+(wild type)[Overexpression]

FYPO:0004325 - sensitive to 5-fluorouracil

References:

PMID:37445861

Genotypes:

coq3delta

FYPO:0000093 - sensitive to arsenic

References:

PMID:27558664

Genotypes:

coq3delta

FYPO:0000096 - sensitive to cadmium

References:

Genotypes:

coq3delta

FYPO:0003384 - sensitive to chromium

References:

PMID:30148840

Genotypes:

coq3delta

FYPO:0000102 - sensitive to cisplatin

References:

PMID:26791325

Genotypes:

coq3delta

FYPO:0001245 - sensitive to cobalt

References:

PMID:27053105

Genotypes:

coq3delta

FYPO:0000103 - sensitive to copper

References:

Genotypes:

coq3delta

FYPO:0003559 - sensitive to doxorubicin

References:

PMID:23365689

Genotypes:

coq3delta

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

coq3delta

FYPO:0004983 - sensitive to vorinostat

References:

PMID:26791325

Genotypes:

coq3delta

FYPO:0002476 - viable vacuolated vegetative cell, abnormal cell shape, normal cell size

References:

PMID:23697806

Genotypes:

coq3delta

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

coq3delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

PMID:21511999

Protein features

ID	Name	InterPro name	DB name
PF13489	Methyltransf_23		Pfam
cd02440	AdoMet_MTases		CDD
G3DSA:3.40.50.150		SAM-dependent_MTases_sf	CATH-Gene3D
SSF53335		SAM-dependent_MTases_sf	SUPERFAMILY
PTHR43464			PANTHER
TIGR01983	UbiG	UbiG_MeTrfase	NCBIFAM
MF_00472	UbiG	UbiG_MeTrfase	HAMAP

Orthologs

COQ3 (HGNC:18175) Homo sapiens
coq3 (SJAG_04642) Schizosaccharomyces japonicus
COQ3 (YOL096C) Saccharomyces cerevisiae

References / Literature

PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.: Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595
PMID:23365689 - Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeast.: Tay Z et al. PLoS One 2013;8(1):e55041
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:27558664 - Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.: Guo L et al. G3 (Bethesda) 2016 Oct 13;6(10):3317-3333
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:25647499 - Production of CoQ10 in fission yeast by expression of genes responsible for CoQ10 biosynthesis.: Moriyama D et al. Biosci Biotechnol Biochem 2015;79(6):1026-33
PMID:27053105 - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.: Burr R et al. J Biol Chem 2016 Jun 03;291(23):12171-83
PMID:37859837 - In fission yeast, 65 non-essential mitochondrial proteins related to respiration and stress become essential in low-glucose conditions.: Mori A et al. R Soc Open Sci 2023 Oct;10(10):230404
PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.: Sun LL et al. PLoS Genet 2013;9(8):e1003715
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:27611590 - Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.: McDonald KR et al. PLoS Genet 2016 Sep;12(9):e1006238
PMID:37156397 - Identification of novel coenzyme Q 10 biosynthetic proteins Coq11 and Coq12 in Schizosaccharomyces pombe.: Nishida I et al. J Biol Chem 2023 Jun;299(6):104797
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.: Mata J et al. Nat Genet 2002 Sep;32(1):143-7
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.: Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39
PMID:18808426 - Comparison of a coq7 deletion mutant with other respiration-defective mutants in fission yeast.: Miki R et al. FEBS J 2008 Nov;275(21):5309-24
GO_REF:0000116 - Automatic Gene Ontology annotation based on Rhea mapping.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26791325 - Predicting chemotherapeutic drug combinations through gene network profiling.: Nguyen TT et al. Sci Rep 2016 Jan 21;6:18658
PMID:37445861 - Resistance to Chemotherapeutic 5-Fluorouracil Conferred by Modulation of Heterochromatic Integrity through Ino80 Function in Fission Yeast.: Lim KK et al. Int J Mol Sci 2023 Jun 26;24(13)
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24911838 - Functional conservation of coenzyme Q biosynthetic genes among yeasts, plants, and humans.: Hayashi K et al. PLoS One 2014;9(6):e99038
PMID:18665268 - Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.: Zuin A et al. PLoS One 2008 Jul 30;3(7):e2842
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:31030285 - CoQ 10 production in Schizosaccharomyces pombe is increased by reduction of glucose levels or deletion of pka1.: Nishida I et al. Appl Microbiol Biotechnol 2019 Jun;103(12):4899-4915