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protein coding gene - hmg1 (SPCC162.09c) - 3-hydroxy-3-methylglutaryl-CoA reductase Hmg1

Gene summary

Standard name
hmg1
Systematic ID
SPCC162.09c
Product
3-hydroxy-3-methylglutaryl-CoA reductase Hmg1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
its12
UniProt ID
Q10283
ORFeome ID
30/30B08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1561215..1565491 forward strand

Annotation

PBO:0005551 - 1.1.1.34

Complementation

PBO:0018182 - functionally complemented by S. cerevisiae HMG1

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PBO:0018183 - functionally complemented by S. cerevisiae HMG2 catalytic domain

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Disease association

MONDO:0957270 - muscular dystrophy, limb-girdle, autosomal recessive 28

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GO biological process

GO:0015936 - coenzyme A metabolic process

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GO:0006696 - ergosterol biosynthetic process

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GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway

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GO:0045337 - trans, trans-farnesyl diphosphate biosynthetic process

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GO cellular component

GO:0005783 - endoplasmic reticulum

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GO:0005789 - endoplasmic reticulum membrane

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GO:0005635 - nuclear envelope

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GO:0031965 - nuclear membrane

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GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network

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GO:0005778 - peroxisomal membrane

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GO molecular function

GO:0004420 - hydroxymethylglutaryl-CoA reductase (NADPH) activity

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GO:0005515 - protein binding

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GO:0032935 - sterol sensor activity

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Modification

MOD:00006 - N-glycosylated residue

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MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00696 - phosphorylated residue

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MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0000032 - abnormal cytokinesis during vegetative growth

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Genotypes:

FYPO:0000046 - decreased cell population growth

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000082 - decreased cell population growth at high temperature

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Genotypes:

FYPO:0002321 - decreased cellular ergosterol level

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Genotypes:

FYPO:0002322 - decreased cellular FPP level

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Genotypes:

FYPO:0002323 - decreased cellular GGPP level

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Genotypes:

FYPO:0002324 - decreased cellular lanosterol level

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Genotypes:

FYPO:0002320 - decreased cellular squalene level

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Genotypes:

FYPO:0001784 - excess endoplasmic reticulum membrane present

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Genotypes:

FYPO:0000253 - increased HMG-CoA reductase activity

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Genotypes:

FYPO:0000650 - increased septation index

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Genotypes:

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

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Genotypes:

FYPO:0002674 - normal protein localization to plasma membrane

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Genotypes:

FYPO:0000075 - resistance to lovastatin

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Genotypes:

FYPO:0002720 - sensitive to beta-glucanase

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Genotypes:

FYPO:0000110 - sensitive to pravastatin

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Genotypes:

FYPO:0000086 - sensitive to tacrolimus

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Genotypes:

FYPO:0002328 - sensitive to terbinafine

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00368HMG-CoA_redHMG_CoA_RdtasePfam
PF12349Sterol-sensingHMGCR/SNAP/NPC1-like_SSDPfam
cd00643HMG-CoA_reductase_classIHMG_CoA_Rdtase_eu_arcCDD
PS00066HMG_COA_REDUCTASE_1HMG_CoA_Rdtase_CSPROSITE patterns
PS00318HMG_COA_REDUCTASE_2HMG_CoA_Rdtase_CSPROSITE patterns
PS50065HMG_COA_REDUCTASE_4HMG_CoA_RdtasePROSITE profiles
PS50156SSDSSDPROSITE profiles
PR00071HMGCOARDTASEHMG_CoA_RdtasePRINTS
G3DSA:1.10.3270.10:FF:000001CATH-FunFam
G3DSA:3.30.70.420:FF:000001CATH-FunFam
G3DSA:3.90.770.10:FF:000001CATH-FunFam
G3DSA:1.10.3270.10HMG_CoA_Rdtase_NCATH-Gene3D
G3DSA:3.30.70.420HMG_CoA_Rdtase_NAD(P)-bd_sfCATH-Gene3D
G3DSA:3.90.770.10HMG_CoA_Rdtase_cat_sfCATH-Gene3D
SSF55035HMG_CoA_Rdtase_NAD(P)-bd_sfSUPERFAMILY
SSF56542HMG_CoA_Rdtase_sub-bd_dom_sfSUPERFAMILY
PTHR10572HMG_CoA_RdtasePANTHER
TIGR00533HMG_CoA_R_NADPHMG_CoA_Rdtase_eu_arcNCBIFAM
Transmembrane alpha helixDeepTMHMM
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder

Orthologs

References / Literature

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:20576575 - Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating alpha-asarone-based HMG-CoA reductase inhibitors.
Argüelles N et al. Bioorg Med Chem 2010 Jun 15;18(12):4238-48
PMID:23145048 - A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast.
Takami T et al. PLoS One 2012;7(11):e49004
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21680738 - Glucose controls phosphoregulation of hydroxymethylglutaryl coenzyme A reductase through the protein phosphatase 2A-related phosphatase protein, Ppe1, and Insig in fission yeast.
Burg JS et al. J Biol Chem 2011 Aug 05;286(31):27139-46
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:8896278 - Molecular, functional and evolutionary characterization of the gene encoding HMG-CoA reductase in the fission yeast, Schizosaccharomyces pombe.
Lum PY et al. Yeast 1996 Sep 15;12(11):1107-24
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:25647499 - Production of CoQ10 in fission yeast by expression of genes responsible for CoQ10 biosynthesis.
Moriyama D et al. Biosci Biotechnol Biochem 2015;79(6):1026-33
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:21801748 - Regulation of HMG-CoA reductase in mammals and yeast.
Burg JS et al. Prog Lipid Res 2011 Oct;50(4):403-10
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
GO_REF:0000002 - Comments
PMID:36799444 - Inner nuclear membrane proteins Lem2 and Bqt4 interact with different lipid synthesis enzymes in fission yeast.
Hirano Y et al. J Biochem 2023 Jun 30;174(1):33-46
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20847589 - Isolation of a fission yeast mutant cell affected in MAP kinase signaling and sterol biosynthesis.
Imagawa K et al. Kobe J Med Sci 2009 Jun 05;55(2):E30-5
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:19041767 - Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast.
Burg JS et al. Cell Metab 2008 Dec;8(6):522-31
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:16270032 - INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins.
Flury I et al. EMBO J 2005 Nov 16;24(22):3917-26
PMID:19486165 - Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast.
Fang Y et al. Genes Cells 2009 Jun;14(6):759-71
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:15797383 - SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast.
Hughes AL et al. Cell 2005 Mar 25;120(6):831-42
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.