protein coding gene - urk1 (SPCC162.11c) - uridine kinase/uracil phosphoribosyltransferase

Gene summary

Standard name: urk1
Systematic ID: SPCC162.11c
Product: uridine kinase/uracil phosphoribosyltransferase
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O74427
ORFeome ID: 21/21B07
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome III: 1555999..1557913 forward strand

Annotation

PBO:0002757 - 2.4.2.9

PBO:0005547 - 2.7.1.48

GO biological process

GO:0044211 - CTP salvage

References:

GO_REF:0000041

GO:0006206 - pyrimidine nucleobase metabolic process

References:

GO_REF:0000051

GO:0044206 - UMP salvage

References:

GO_REF:0000041

GO cellular component

GO:0032153 - cell division site

References:

PMID:16823372

GO:0005829 - cytosol

References:

PMID:16823372

GO:0044732 - mitotic spindle pole body

References:

PMID:16823372

GO:0005634 - nucleus

References:

PMID:16823372

GO molecular function

GO:0005524 - ATP binding

References:

GO_REF:0000002

GO:0043771 - cytidine kinase activity

References:

GO_REF:0000116

GO:0004845 - uracil phosphoribosyltransferase activity

References:

GO_REF:0000051

GO:0004849 - uridine kinase activity

References:

GO_REF:0000033

Modification

MOD:00696 - phosphorylated residue

References:

PMID:19547744

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PMID:33313903

PomGeneEx:0000011 - RNA level increased

References:

PMID:12161753

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000251 - decreased cell population growth on galactose carbon source

References:

PMID:27887640

Genotypes:

urk1delta

FYPO:0000684 - decreased cell population growth on glycerol carbon source

References:

PMID:27887640

Genotypes:

urk1delta

FYPO:0000245 - loss of viability in stationary phase

References:

PMID:34250083

Genotypes:

urk1delta

FYPO:0001986 - resistance to 5-fluorouracil

References:

PMID:27255861

Genotypes:

urk1delta

FYPO:0005253 - resistance to tamoxifen

References:

PMID:26628015

Genotypes:

urk1delta

FYPO:0000085 - sensitive to camptothecin

References:

PMID:20537132

Genotypes:

urk1delta

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

urk1delta

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

PMID:23697806

Genotypes:

urk1delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF14681	UPRTase	PRTase_dom	PFAM
PF00485	PRK	PRK/URK	PFAM
cd02023	UMPK	Uridine_kinase-like	CDD
SM00382	AAA_5	AAA+_ATPase	SMART
PR00988	URIDINKINASE		PRINTS
G3DSA:3.40.50.300:FF:002070			FUNFAM
SSF53271	PRTase-like	PRTase-like	SUPERFAMILY
SSF52540	P-loop containing nucleoside triphosphate hydrolases	P-loop_NTPase	SUPERFAMILY
G3DSA:3.40.50.2020		PRTase-like	GENE3D
G3DSA:3.40.50.300		P-loop_NTPase	GENE3D
PTHR10285	URIDINE KINASE		PANTHER
TIGR00235	udk	Uridine_kinase-like	NCBIFAM
NF004018	PRK05480.1		NCBIFAM

Orthologs

UCKL1 (HGNC:15938) Homo sapiens
urk1 (SJAG_03708) Schizosaccharomyces japonicus
URK1 (YNR012W) Saccharomyces cerevisiae

References / Literature

GO_REF:0000051 - S. pombe keyword mapping
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.: Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.: Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.: Han TX et al. Genome Biol 2010;11(6):R60
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.: Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000041 - Gene Ontology annotation based on UniPathway vocabulary mapping.
GO_REF:0000116 - Automatic Gene Ontology annotation based on Rhea mapping.
PMID:26628015 - Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism.: Zhang X et al. Kobe J Med Sci 2015 Oct 09;61(2):E54-63
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:26890608 - A functional genome-wide genetic screening identifies new pathways controlling the G1/S transcriptional wave.: Gaspa L et al. Cell Cycle 2016;15(5):720-9
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.: Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.: Malecki M et al. Genome Biol 2016 Nov 25;17(1):240
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:27255861 - Genetic evidence for involvement of membrane trafficking in the action of 5-fluorouracil.: Hu L et al. Fungal Genet Biol 2016 Aug;93:17-24
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.: Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.: Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.: Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:24497846 - A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability.: Kriegenburg F et al. PLoS Genet 2014 Jan;10(1):e1004140
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000002 - Comments