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protein coding gene - wtf23 (SPCC1620.02) - wtf meiotic drive antidote Wtf23 OR wtf meiotic drive poison Wtf23

Gene summary

Standard name
wtf23
Systematic ID
SPCC1620.02
Product
wtf meiotic drive antidote Wtf23 OR wtf meiotic drive poison Wtf23
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
wts23, wtf10
UniProt ID
O94409
ORFeome ID
24/24C07
Characterisation status
meiotic driver
Feature type
mRNA gene
Genomic location
chromosome III: 2145527..2147814 forward strand

Annotation

GO biological process

GO:0110134 - meiotic drive

References:

GO cellular component

GO:0072324 - ascus epiplasm

References:

GO:0005737 - cytoplasm

References:

GO:0005789 - endoplasmic reticulum membrane

References:

GO:0005794 - Golgi apparatus

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GO:0140549 - spore inner membrane

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GO:0005774 - vacuolar membrane

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Modification

MOD:00046 - O-phospho-L-serine

References:

Protein features

PBO:0111903 - wtf element

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009072 - increased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0001489 - inviable vegetative cell

References:

Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0016878 - Schizosaccharomyces pombe specific

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF03303WTFWTFPfam
Transmembrane alpha helixDeepTMHMM
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polardisorder_predictionMobiDB-Polar
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte

References / Literature

PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.
Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154
PMID:30991417 - Killer Meiotic Drive and Dynamic Evolution of the wtf Gene Family.
Eickbush MT et al. Mol Biol Evol 2019 Jun 01;36(6):1201-1214
PMID:32032353 - Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all display high gamete-killing efficiency.
Bravo Núñez MA et al. PLoS Genet 2020 Feb;16(2):e1008350
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:12952871 - Retrotransposons and their recognition of pol II promoters: a comprehensive survey of the transposable elements from the complete genome sequence of Schizosaccharomyces pombe.
Bowen NJ et al. Genome Res 2003 Sep;13(9):1984-97
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30475921 - A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver's antidote.
Bravo Núñez MA et al. PLoS Genet 2018 Nov;14(11):e1007836
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28631610 - A large gene family in fission yeast encodes spore killers that subvert Mendel's law.
Hu W et al. Elife 2017 Jun 20;6
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:38097609 - Ubiquitination-mediated Golgi-to-endosome sorting determines the toxin-antidote duality of fission yeast wtf meiotic drivers.
Zheng JX et al. Nat Commun 2023 Dec 14;14(1):8334
GO_REF:0000002 - Comments
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80