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protein coding gene - fzr3 (SPCC1620.04c) - meiotic fizzy-related APC coactivator Fzr3

Gene summary

Standard name
fzr3
Systematic ID
SPCC1620.04c
Product
meiotic fizzy-related APC coactivator Fzr3
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
mug55
UniProt ID
O94411
ORFeome ID
44/44H04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 2149317..2150908 reverse strand

Annotation

GO biological process

GO:0031145 - anaphase-promoting complex-dependent catabolic process

References:

GO cellular component

GO:0005634 - nucleus

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GO molecular function

GO:0010997 - anaphase-promoting complex binding

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GO:1990757 - ubiquitin ligase activator activity

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Protein features

PBO:0111750 - Cdc20/Fizzy subfamily

PBO:0111751 - WD repeat protein

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0005382 - delayed exit from meiosis

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Genotypes:

FYPO:0005414 - increased protein level during meiosis II

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Genotypes:

FYPO:0005416 - increased protein level during meiotic anaphase II

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF24807WD40_CDC20-FzWD40_CDC20-FzPFAM
PS50082WD_REPEATS_2WD40_rptPROSITE_PROFILES
SM00320WD40_4WD40_rptSMART
G3DSA:2.130.10.10:FF:000098FUNFAM
SSF50978WD40 repeat-likeWD40_repeat_dom_sfSUPERFAMILY
G3DSA:2.130.10.10WD40/YVTN_repeat-like_dom_sfGENE3D
PTHR19918CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATEDCdc20/FizzyPANTHER

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21389117 - Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast.
Kimata Y et al. Mol Biol Cell 2011 May;22(9):1486-94
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12