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protein coding gene - SPCC1620.06c - ribose-phosphate pyrophosphokinase

Gene summary

Systematic ID
SPCC1620.06c
Product
ribose-phosphate pyrophosphokinase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94413
ORFeome ID
18/18H04
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 2152833..2155107 reverse strand

Annotation

PBO:0001622 - 2.7.6.1

Disease association

MONDO:0010533 - Arts syndrome

References:

MONDO:0015626 - Charcot-Marie-Tooth disease

References:

MONDO:0010699 - Charcot-Marie-Tooth disease X-linked recessive 5

References:

MONDO:0010577 - hearing loss, X-linked 1

References:

MONDO:0005071 - nervous system disorder

References:

MONDO:0010395 - phosphoribosylpyrophosphate synthetase superactivity

References:

GO biological process

GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process

References:

GO:0006164 - purine nucleotide biosynthetic process

References:

GO:0009156 - ribonucleoside monophosphate biosynthetic process

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0002189 - ribose phosphate diphosphokinase complex

References:

GO molecular function

GO:0000287 - magnesium ion binding

References:

GO:0004749 - ribose phosphate diphosphokinase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000027 - ribosomal density decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF13793Pribosyltran_NPribosyltran_NPFAM
PF14572Pribosyl_synthRib-P_diPkinasePFAM
cd06223PRTases_typeIPRTase_domCDD
PS00114PRPP_SYNTHASEPRib_PP_synth_CSPROSITE_PATTERNS
SM01400Pribosyltran_N_2SMART
G3DSA:3.40.50.2020:FF:000031FUNFAM
G3DSA:3.40.50.2020:FF:000005FUNFAM
SSF53271PRTase-likePRTase-likeSUPERFAMILY
G3DSA:3.40.50.2020PRTase-likeGENE3D
PTHR10210RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBERRib-P_diPkinasePANTHER
TIGR01251ribP_PPkinRib-P_diPkinaseNCBIFAM
NF002320PRK01259.1NCBIFAM

Orthologs

References / Literature

PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:26152728 - A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.
Mathiassen SG et al. J Biol Chem 2015 Aug 21;290(34):21141-21153
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23293578 - Molecular genetics of charcot-marie-tooth disease: from genes to genomes.
Azzedine H et al. Mol Syndromol 2012 Nov;3(5):204-14
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
TreeFam:TF106366 - Unknown title
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000002 - Comments
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7