protein coding gene - yrs1 (SPCC1672.05c) - cytoplasmic tyrosine-tRNA ligase Yrs1

Gene summary

Standard name: yrs1
Systematic ID: SPCC1672.05c
Product: cytoplasmic tyrosine-tRNA ligase Yrs1
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O14055
ORFeome ID: 34/34E02
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome III: 569877..571507 reverse strand

Annotation

PBO:0005195 - 6.1.1.1

Disease association

MONDO:0012012 - Charcot-Marie-Tooth disease dominant intermediate C

References:

PB_REF:0000006

MONDO:0030375 - neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 2

References:

PB_REF:0000006

GO biological process

GO:0002181 - cytoplasmic translation

References:

GO_REF:0000051

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO molecular function

GO:0005524 - ATP binding

References:

GO_REF:0000002

GO:0004831 - tyrosine-tRNA ligase activity

References:

GO_REF:0000033

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

PMID:29996109

MOD:00048 - O4'-phospho-L-tyrosine

References:

PMID:25720772

MOD:00696 - phosphorylated residue

References:

PMID:19547744

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000027 - ribosomal density decreased

References:

PMID:36478272

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

PMID:23697806

Genotypes:

yrs1delta

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

yrs1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

yrs1delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF00579	tRNA-synt_1b	aa-tRNA-synth_Ic	PFAM
cd00805	TyrRS_core	Tyr-tRNA-ligase	CDD
PR01040	TRNASYNTHTYR	Tyr-tRNA-ligase	PRINTS
G3DSA:3.40.50.620:FF:000040			FUNFAM
SSF52374	Nucleotidylyl transferase		SUPERFAMILY
G3DSA:1.10.240.10			GENE3D
G3DSA:3.40.50.620	HUPs	Rossmann-like_a/b/a_fold	GENE3D
PTHR46264	TYROSINE-TRNA LIGASE	Tyr-tRNA_synthase	PANTHER
PIRSF006588	TyrRS_arch_euk	Tyr-tRNA-ligase_arc/euk-type	PIRSF
mobidb-lite-Disorder	disorder_prediction		MOBIDB-Disorder
mobidb-lite-Low-complexity	disorder_prediction		MOBIDB-Low-complexity
mobidb-lite-Positive-Polyelectrolyte	disorder_prediction		MOBIDB-Positive-Polyelectrolyte
TIGR00234	tyrS	Tyr-tRNA-ligase	NCBIFAM
NF006330	PRK08560.1		NCBIFAM

Orthologs

YARS1 (HGNC:12840) Homo sapiens
yrs1 (SJAG_00243) Schizosaccharomyces japonicus
TYS1 (YGR185C) Saccharomyces cerevisiae

References / Literature

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.: Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
GO_REF:0000051 - S. pombe keyword mapping
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000002 - Comments
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.: Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.: Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.: Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.: Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.: Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6