PomBase - protein coding gene - utp21 (SPCC1672.07) - small subunit processome, U3 snoRNP-associated protein Utp21 - The Schizosaccharomyces pombe genome database

Protein features

ID	Name	InterPro name	DB name
PF25168	Beta-prop_WDR36-Utp21_2nd	Beta-prop_WDR36-Utp21_2nd	PFAM
PF04192	Utp21	WDR36/Utp21_C	PFAM
PF25171	Beta-prop_WDR36-Utp21_1st	WDR36-Utp21_N	PFAM
PS00678	WD_REPEATS_1	WD40_repeat_CS	PROSITE_PATTERNS
PS50294	WD_REPEATS_REGION		PROSITE_PROFILES
PS50082	WD_REPEATS_2	WD40_rpt	PROSITE_PROFILES
SM00320	WD40_4	WD40_rpt	SMART
SSF50978	WD40 repeat-like	WD40_repeat_dom_sf	SUPERFAMILY
G3DSA:2.130.10.10		WD40/YVTN_repeat-like_dom_sf	GENE3D
PTHR22840	WD REPEAT-CONTAINING PROTEIN 36		PANTHER

References / Literature

PMID:38051102 - Fission Yeast TORC1 Promotes Cell Proliferation through Sfp1, a Transcription Factor Involved in Ribosome Biogenesis.: Tai YT et al. Mol Cell Biol 2023 Dec 05;:1-18
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.: Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.: Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:36423630 - Chromatin localization of nucleophosmin organizes ribosome biogenesis.: Ugolini I et al. Mol Cell 2022 Dec 01;82(23):4443-4457.e9
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PB_REF:0000003 - Disease Association Curation
PMID:21436456 - Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.: Zhang K et al. Science 2011 Mar 25;331(6024):1624-7
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.: Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.: Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.: Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.: Das J et al. Sci Signal 2013 May 21;6(276):ra38
PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.: Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.: Lee J et al. Nat Commun 2017 Feb 20;8:14527

protein coding gene - utp21 (SPCC1672.07) - small subunit processome, U3 snoRNP-associated protein Utp21

Gene summary

Annotation

Disease association

MONDO:0005041 - glaucoma

GO biological process

GO:0006364 - rRNA processing

GO cellular component

GO:0032153 - cell division site

GO:0005829 - cytosol

GO:0072686 - mitotic spindle

GO:0005634 - nucleus

GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome

GO:0032040 - small-subunit processome

Modification

MOD:01149 - sumoylated lysine

MOD:01148 - ubiquitinylated lysine

Protein features

PBO:0111751 - WD repeat protein

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

PomGeneEx:0000027 - ribosomal density decreased

PomGeneEx:0000012 - RNA level decreased

Quantitative gene expression

PBO:0006310 - protein level

PBO:0011963 - RNA level

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

FYPO:0002061 - inviable vegetative cell population

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

Orthologs

References / Literature