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protein coding gene - cdc31 (SPCC1682.04) - spindle pole body half bridge protein, centrin Cdc31

Gene summary

Standard name
cdc31
Systematic ID
SPCC1682.04
Product
spindle pole body half bridge protein, centrin Cdc31
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74435
ORFeome ID
08/08B10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 378206..381250 forward strand

Annotation

GO biological process

GO:1990395 - meiotic spindle pole body organization

References:

GO:1903087 - mitotic spindle pole body duplication

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0061496 - half bridge of mitotic spindle pole body

References:

GO:0035974 - meiotic spindle pole body

References:

GO:0044732 - mitotic spindle pole body

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0005509 - calcium ion binding

References:

GO:0008017 - microtubule binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Protein features

PBO:0111761 - EF hand

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000608 - abnormal cell cycle arrest in mitotic M phase

References:

Genotypes:

FYPO:0000151 - abnormal meiotic chromosome segregation

References:

Genotypes:

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0003738 - abnormal mitotic cell cycle arrest with condensed chromosomes

References:

Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0007257 - delayed onset of protein localization to meiotic spindle pole body during meiosis I

References:

Genotypes:

FYPO:0002281 - inviable after spore germination with abnormal germ tube morphology

References:

Genotypes:

FYPO:0005023 - inviable elongated septated mononucleate vegetative cell

References:

Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002273 - inviable vegetative cell with abnormal cell morphology

References:

Genotypes:

FYPO:0000276 - monopolar mitotic spindle

References:

Genotypes:

FYPO:0003788 - nuclear envelope protrusion present during mitosis

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF13499EF-hand_7EF_hand_domPFAM
cd00051EFhEF_hand_domCDD
PS00018EF_HAND_1EF_Hand_1_Ca_BSPROSITE_PATTERNS
PS50222EF_HAND_2EF_hand_domPROSITE_PROFILES
SM00054efh_1EF_hand_domSMART
G3DSA:1.10.238.10:FF:000077FUNFAM
SSF47473EF-handEF-hand-dom_pairSUPERFAMILY
G3DSA:1.10.238.10GENE3D
PTHR23048MYOSIN LIGHT CHAIN 1, 3CALM/Myosin/TropC-likePANTHER
CoilCoilCOILS
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Positive-Polyelectrolytedisorder_predictionMOBIDB-Positive-Polyelectrolyte

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:22042620 - Brr6 drives the Schizosaccharomyces pombe spindle pole body nuclear envelope insertion/extrusion cycle.
Tamm T et al. J Cell Biol 2011 Oct 31;195(3):467-84
PMID:24055157 - CK1 is required for a mitotic checkpoint that delays cytokinesis.
Johnson AE et al. Curr Biol 2013 Oct 07;23(19):1920-6
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:12857865 - Fission yeast cdc31p is a component of the half-bridge and controls SPB duplication.
Paoletti A et al. Mol Biol Cell 2003 Jul;14(7):2793-808
PMID:9256449 - Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene.
Middendorp S et al. Proc Natl Acad Sci U S A 1997 Aug 19;94(17):9141-6
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:19443688 - Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast.
Fischer T et al. Proc Natl Acad Sci U S A 2009 Jun 02;106(22):8998-9003
PMID:22438582 - Spindle pole body components are reorganized during fission yeast meiosis.
Ohta M et al. Mol Biol Cell 2012 May;23(10):1799-811
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:28619713 - Molecular model of fission yeast centrosome assembly determined by superresolution imaging.
Bestul AJ et al. J Cell Biol 2017 Aug 07;216(8):2409-2424
PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.
Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26175449 - Monitoring SPB biogenesis in fission yeast with high resolution and quantitative fluorescent microscopy.
Bouhlel IB et al. Methods Cell Biol 2015;129:383-392