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protein coding gene - srp68 (SPCC1682.05c) - signal recognition particle subunit

Gene summary

Standard name
srp68
Systematic ID
SPCC1682.05c
Product
signal recognition particle subunit
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74436
ORFeome ID
27/27B11
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 378099..380848 reverse strand

Annotation

Disease association

MONDO:0957809 - neutropenia, severe congenital, 10, autosomal recessive

References:

GO biological process

GO:0006617 - SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005786 - signal recognition particle, endoplasmic reticulum targeting

References:

GO molecular function

GO:0008312 - 7S RNA binding

References:

GO:0030942 - endoplasmic reticulum signal sequence receptor activity

References:

GO:0005047 - signal recognition particle binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

Protein features

PBO:0111755 - TPR repeat protein

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF16969SRP68SRP68Pfam
G3DSA:1.10.3450.40SRP68_N_sfCATH-Gene3D
PTHR12860SRP68PANTHER
PIRSF038995SRP68SRP68PIRSF
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder

Orthologs

References / Literature

GO_REF:0000002 - Comments
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.
Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26152728 - A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.
Mathiassen SG et al. J Biol Chem 2015 Aug 21;290(34):21141-21153
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:20519959 - S. pombe genome deletion project: an update.
Spirek M et al. Cell Cycle 2010 Jun 15;9(12):2399-402
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7