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protein coding gene - ubp1 (SPCC16A11.12c) - ubiquitin C-terminal hydrolase Ubp1

Gene summary

Standard name
ubp1
Systematic ID
SPCC16A11.12c
Product
ubiquitin C-terminal hydrolase Ubp1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9USM5
ORFeome ID
47/47C02
Characterisation status
conserved unknown
Feature type
mRNA gene
Genomic location
chromosome III: 889281..892315 reverse strand

Annotation

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO molecular function

GO:0004843 - cysteine-type deubiquitinase activity

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GO:0140492 - metal-dependent deubiquitinase activity

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00048 - O4'-phospho-L-tyrosine

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Multi-locus phenotype

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0000785 - sensitive to formamide

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0001491 - viable vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF06337DUSPPept_C19_DUSPPFAM
PF00443UCHPeptidase_C19_UCHPFAM
cd02674Peptidase_C19RCDD
PS00973USP_2USP_CSPROSITE_PATTERNS
PS00972USP_1USP_CSPROSITE_PATTERNS
PS51283DUSPPept_C19_DUSPPROSITE_PROFILES
PS50235USP_3USPPROSITE_PROFILES
SM00695duspPept_C19_DUSPSMART
G3DSA:3.90.70.10:FF:000537FUNFAM
SSF143791DUSP-likeDUSP-like_sfSUPERFAMILY
SSF54001Cysteine proteinasesPapain-like_cys_pep_sfSUPERFAMILY
G3DSA:3.90.70.10Cysteine proteinasesGENE3D
G3DSA:3.10.20.90GENE3D
G3DSA:3.30.2230.10DUSP-like_sfGENE3D
PTHR21646UBIQUITIN CARBOXYL-TERMINAL HYDROLASEUb_carboxyl-term_hydrolasePANTHER

Orthologs

References / Literature

PMID:29975113 - Relief of the Dma1-mediated checkpoint requires Dma1 autoubiquitination and dynamic localization.
Jones CM et al. Mol Biol Cell 2018 Sep 01;29(18):2176-2189
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.
Chen JS et al. Yeast 2016 Sep;33(9):507-17
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:20838651 - A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.
Kouranti I et al. PLoS Biol 2010 Sep 07;8(9)
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000003 - Gene Ontology annotation based on Enzyme Commission mapping