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protein coding gene - sfh1 (SPCC16A11.14) - RSC complex subunit Sfh1

Gene summary

Standard name
sfh1
Systematic ID
SPCC16A11.14
Product
RSC complex subunit Sfh1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPNCRNA.125
UniProt ID
Q9USM3
ORFeome ID
20/20B02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 894153..895679 forward strand

Annotation

Disease association

MONDO:0013820 - intellectual disability, autosomal dominant 15

References:

MONDO:0012252 - rhabdoid tumor predisposition syndrome 1

References:

MONDO:0024517 - SMARCB1-related schwannomatosis

References:

GO biological process

GO:0033696 - heterochromatin boundary formation

References:

GO:0006357 - regulation of transcription by RNA polymerase II

References:

GO:0045815 - transcription initiation-coupled chromatin remodeling

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0000228 - nuclear chromosome

References:

GO:0005634 - nucleus

References:

GO:0016586 - RSC-type complex

References:

GO molecular function

GO:0043565 - sequence-specific DNA binding

References:

GO:0003712 - transcription coregulator activity

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GO:0008270 - zinc ion binding

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00048 - O4'-phospho-L-tyrosine

References:

Multi-locus phenotype

FYPO:0005932 - decreased nucleosome occupancy at long terminal repeat

References:

Genotypes:

FYPO:0003105 - increased transposable element-derived small RNA level

References:

Genotypes:

FYPO:0006842 - normal spatial extent of CENP-A containing nucleosome assembly

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

Protein features

PBO:0111770 - zf-GATA type

PBO:0111743 - zinc finger protein

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000400 - abnormal cell cycle arrest at mitotic G2/M phase transition

References:

Genotypes:

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0000141 - abnormal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0003730 - abolished cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0001270 - complete but unequal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0001162 - decreased cell population growth on raffinose carbon source

References:

Genotypes:

FYPO:0001176 - decreased cell population growth on sucrose carbon source

References:

Genotypes:

FYPO:0002842 - decreased protein localization to centromere outer repeat

References:

Genotypes:

FYPO:0006599 - decreased protein localization to centromeric chromatin during vegetative growth

References:

Genotypes:

FYPO:0004345 - decreased protein localization to chromatin at long terminal repeat

References:

Genotypes:

FYPO:0008249 - decreased protein localization to chromatin at protein coding gene

References:

Genotypes:

FYPO:0008035 - ectopic CENP-A containing chromatin assembly at pericentromeric heterochromatin

References:

Genotypes:

FYPO:0003004 - increased cellular reactive oxygen species level during vegetative growth

References:

Genotypes:

FYPO:0005371 - increased linear minichromosome loss during vegetative growth

References:

Genotypes:

FYPO:0008036 - increased nucleosome occupancy at CENP-A boundary

References:

Genotypes:

FYPO:0000972 - increased number of Rad52 foci during vegetative growth

References:

Genotypes:

FYPO:0004380 - increased protein localization to pericentric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0002411 - inviable curved elongated vegetative cell

References:

Genotypes:

FYPO:0004922 - inviable elongated mononucleate aseptate cell with cell cycle arrest at mitotic G2/M phase transition

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001387 - loss of viability at high temperature

References:

Genotypes:

FYPO:0000961 - normal growth on sorbitol

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Genotypes:

FYPO:0001174 - normal growth on sucrose carbon source

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Genotypes:

FYPO:0000863 - normal histone H3-K9 dimethylation at centromere inner repeat during vegetative growth

References:

Genotypes:

FYPO:0004743 - normal histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0001839 - normal minichromosome loss

References:

Genotypes:

FYPO:0008457 - normal nucleosome occupancy at long terminal repeat region

References:

Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0005079 - normal protein localization to chromatin at centromere central core

References:

Genotypes:

FYPO:0005082 - normal protein localization to chromatin at long terminal repeat

References:

Genotypes:

FYPO:0002389 - normal protein localization to heterochromatin at centromere outer repeat

References:

Genotypes:

FYPO:0004579 - normal transposable element-derived small RNA level

References:

Genotypes:

FYPO:0009039 - resistance to potassium chloride

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0000785 - sensitive to formamide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

FYPO:0000750 - sensitive to silver ions

References:

Genotypes:

FYPO:0006929 - sensitive to silver nanoparticles

References:

Genotypes:

FYPO:0005889 - sensitive to sodium chloride

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0009063 - sensitive to X-rays during vegetative growth

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0011513 - merged with ncRNA SPNCRNA.125

Protein features

IDNameInterPro nameDB name
PF00320GATAZnf_GATAPfam
PF04855SNF5SNF5Pfam
SM00401ZnF_GATAZnf_GATASMART
G3DSA:3.30.50.10Znf_NHR/GATACATH-Gene3D
SSF57716SUPERFAMILY
PTHR10019PANTHER
CoilCOILS
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte

Orthologs

References / Literature

PMID:29294138 - Editor's Highlight: A Genome-wide Screening of Target Genes Against Silver Nanoparticles in Fission Yeast.
Lee AR et al. Toxicol Sci 2018 Jan 01;161(1):171-185
PMID:30155942 - Sfh1, an essential component of the RSC chromatin remodeling complex, maintains genome integrity in fission yeast.
Kotomura N et al. Genes Cells 2018 Sep;23(9):738-752
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000002 - Comments
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:36200823 - The chromatin remodeler RSC prevents ectopic CENP-A propagation into pericentromeric heterochromatin at the chromatin boundary.
Tsunemine S et al. Nucleic Acids Res 2022 Oct 28;50(19):10914-10928
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:14655046 - Two-hybrid search for proteins that interact with Sad1 and Kms1, two membrane-bound components of the spindle pole body in fission yeast.
Miki F et al. Mol Genet Genomics 2004 Jan;270(6):449-61
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:18622392 - Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast.
Monahan BJ et al. Nat Struct Mol Biol 2008 Aug;15(8):873-80
PMID:19682301 - A large complex mediated by Moc1, Moc2 and Cpc2 regulates sexual differentiation in fission yeast.
Paul SK et al. FEBS J 2009 Sep;276(18):5076-93
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67