protein coding gene - taf6 (SPCC16C4.18c) - SAGA complex/transcription factor TFIID complex histone H4-like subunit Taf6

Gene summary

Standard name: taf6
Systematic ID: SPCC16C4.18c
Product: SAGA complex/transcription factor TFIID complex histone H4-like subunit Taf6
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: taf50
UniProt ID: O74462
ORFeome ID: 24/24F04
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome III: 699064..701697 reverse strand

Annotation

Disease association

MONDO:0014931 - Alazami-Yuan syndrome

References:

PB_REF:0000006

GO biological process

GO:0051123 - RNA polymerase II preinitiation complex assembly

References:

GO_REF:0000033

GO:0006367 - transcription initiation at RNA polymerase II promoter

References:

PMID:8303296

GO:0045815 - transcription initiation-coupled chromatin remodeling

References:

GO_REF:0000111

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005634 - nucleus

References:

PMID:16823372

GO:0000124 - SAGA complex

References:

GO:0005669 - transcription factor TFIID complex

References:

GO molecular function

GO:0005515 - protein binding

References:

PMID:11972332

GO:0140378 - protein complex scaffold activity

References:

PMID:31969703

GO:0016251 - RNA polymerase II general transcription initiation factor activity

References:

PMID:8303296

GO:0003713 - transcription coactivator activity

References:

GO_REF:0000033

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:30726745

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Protein features

PBO:0111763 - histone fold

References:

PMID:11972332

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

PMID:23697806

Genotypes:

taf6delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

taf6delta

FYPO:0006680 - sensitive to bisphenol A

References:

PMID:30099677

Genotypes:

taf6delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF07571	TAF6_C	TAF6_C	PFAM
PF02969	TAF	TAF_TATA-bd_Histone-like_dom	PFAM
cd22931	HFD_TAF6		CDD
cd08050	TAF6C	TAF6_C	CDD
SM00803	TAF_cls	TAF_TATA-bd_Histone-like_dom	SMART
G3DSA:1.10.20.10:FF:000033			FUNFAM
G3DSA:1.25.40.770:FF:000001			FUNFAM
SSF47113	Histone-fold	Histone-fold	SUPERFAMILY
SSF48371	ARM repeat	ARM-type_fold	SUPERFAMILY
G3DSA:1.25.40.770		TAF6_C_sf	GENE3D
G3DSA:1.10.20.10	Histone, subunit A	Histone-fold	GENE3D
PTHR10221	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6	TAF6	PANTHER

Orthologs

TAF6 (HGNC:11540) Homo sapiens
TAF6L (HGNC:17305) Homo sapiens
taf6 (SJAG_04274) Schizosaccharomyces japonicus
TAF6 (YGL112C) Saccharomyces cerevisiae

References / Literature

PMID:19056896 - The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.: Helmlinger D et al. Genes Dev 2008 Nov 15;22(22):3184-95
PMID:21642955 - Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.: Helmlinger D et al. EMBO J 2011 Jun 03;30(14):2843-52
PMID:30573453 - Anti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin.: Bao K et al. Genes Dev 2019 Jan 01;33(1-2):116-126
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:19913479 - Cryo-EM reveals promoter DNA binding and conformational flexibility of the general transcription factor TFIID.: Elmlund H et al. Structure 2009 Nov 11;17(11):1442-52
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.: Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:30099677 - Genome-wide evidences of bisphenol a toxicity using Schizosaccharomyces pombe.: Kim DM et al. Arch Pharm Res 2018 Aug;41(8):830-837
PMID:8303296 - RNA polymerase II initiation factor interactions and transcription start site selection.: Li Y et al. Science 1994 Feb 11;263(5148):805-7
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:11972332 - Identification of histone H4-like TAF in Schizosaccharomyces pombe as a protein that interacts with WD repeat-containing TAF.: Mitsuzawa H et al. Nucleic Acids Res 2002 May 01;30(9):1952-8
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.: Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:29079657 - TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.: Laboucarié T et al. EMBO Rep 2017 Dec;18(12):2197-2218
PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.: Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:31969703 - Structure of the transcription coactivator SAGA.: Wang H et al. Nature 2020 Jan;577(7792):717-720