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protein coding gene - taf6 (SPCC16C4.18c) - SAGA complex/transcription factor TFIID complex histone H4-like subunit Taf6

Gene summary

Standard name
taf6
Systematic ID
SPCC16C4.18c
Product
SAGA complex/transcription factor TFIID complex histone H4-like subunit Taf6
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
taf50
UniProt ID
O74462
ORFeome ID
24/24F04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 699064..701697 reverse strand

Annotation

Disease association

MONDO:0014931 - Alazami-Yuan syndrome

References:

GO biological process

GO:0051123 - RNA polymerase II preinitiation complex assembly

References:

GO:0006367 - transcription initiation at RNA polymerase II promoter

References:

GO:0045815 - transcription initiation-coupled chromatin remodeling

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO:0000124 - SAGA complex

References:

GO:0005669 - transcription factor TFIID complex

References:

GO molecular function

GO:0140378 - protein complex scaffold activity

References:

GO:0016251 - RNA polymerase II general transcription initiation factor activity

References:

GO:0003713 - transcription coactivator activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

Protein features

PBO:0111763 - histone fold

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0006680 - sensitive to bisphenol A

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02969TAFTAF_TATA-bd_Histone-like_domPfam
PF07571TAF6_CTAF6_CPfam
cd08050TAF6CTAF6_CCDD
cd22931HFD_TAF6CDD
SM00803TAFTAF_TATA-bd_Histone-like_domSMART
G3DSA:1.10.20.10:FF:000033CATH-FunFam
G3DSA:1.25.40.770:FF:000001CATH-FunFam
G3DSA:1.10.20.10Histone-foldCATH-Gene3D
G3DSA:1.25.40.770TAF6_C_sfCATH-Gene3D
SSF47113Histone-foldSUPERFAMILY
SSF48371ARM-type_foldSUPERFAMILY
PTHR10221TAF6PANTHER

Orthologs

References / Literature

PMID:8303296 - RNA polymerase II initiation factor interactions and transcription start site selection.
Li Y et al. Science 1994 Feb 11;263(5148):805-7
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:11972332 - Identification of histone H4-like TAF in Schizosaccharomyces pombe as a protein that interacts with WD repeat-containing TAF.
Mitsuzawa H et al. Nucleic Acids Res 2002 May 01;30(9):1952-8
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:30573453 - Anti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin.
Bao K et al. Genes Dev 2019 Jan 01;33(1-2):116-126
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30099677 - Genome-wide evidences of bisphenol a toxicity using Schizosaccharomyces pombe.
Kim DM et al. Arch Pharm Res 2018 Aug;41(8):830-837
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:19913479 - Cryo-EM reveals promoter DNA binding and conformational flexibility of the general transcription factor TFIID.
Elmlund H et al. Structure 2009 Nov 11;17(11):1442-52
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:29079657 - TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.
Laboucarié T et al. EMBO Rep 2017 Dec;18(12):2197-2218
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:31969703 - Structure of the transcription coactivator SAGA.
Wang H et al. Nature 2020 Jan;577(7792):717-720
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.
Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902
PMID:19056896 - The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.
Helmlinger D et al. Genes Dev 2008 Nov 15;22(22):3184-95
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:21642955 - Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.
Helmlinger D et al. EMBO J 2011 Jun 03;30(14):2843-52
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7